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H2BC21 and HSPD1
Data Source:
HPRD
(in vivo, in vitro)
H2BC21
HSPD1
Description
H2B clustered histone 21
heat shock protein family D (Hsp60) member 1
Image
GO Annotations
Cellular Component
Nucleosome
Extracellular Space
Nucleus
Nucleoplasm
Cytosol
Extracellular Exosome
Extracellular Space
Cytoplasm
Mitochondrion
Mitochondrial Inner Membrane
Mitochondrial Matrix
Early Endosome
Cytosol
Plasma Membrane
Clathrin-coated Pit
Cell Surface
Membrane
Coated Vesicle
Secretory Granule
Protein-containing Complex
Lipopolysaccharide Receptor Complex
Extracellular Exosome
Molecular Function
DNA Binding
Protein Binding
Protein Heterodimerization Activity
Lipopolysaccharide Binding
P53 Binding
DNA Replication Origin Binding
Single-stranded DNA Binding
RNA Binding
Double-stranded RNA Binding
Protein Binding
ATP Binding
High-density Lipoprotein Particle Binding
Isomerase Activity
ATPase Activity
Enzyme Binding
Ubiquitin Protein Ligase Binding
Apolipoprotein Binding
Apolipoprotein A-I Binding
Unfolded Protein Binding
Chaperone Binding
Biological Process
Innate Immune Response In Mucosa
Nucleosome Assembly
Antibacterial Humoral Response
Defense Response To Gram-positive Bacterium
Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
MyD88-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell
Regulation Of Transcription By RNA Polymerase II
Protein Folding
'de Novo' Protein Folding
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Response To Unfolded Protein
Apoptotic Mitochondrial Changes
Response To Cold
Viral Process
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Interferon-gamma Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-6 Production
Mitochondrial Unfolded Protein Response
Protein Refolding
B Cell Proliferation
T Cell Activation
B Cell Activation
Positive Regulation Of Macrophage Activation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Adhesion Of Symbiont To Host
Protein Import Into Mitochondrial Intermembrane Space
Isotype Switching To IgG Isotypes
Protein Stabilization
Positive Regulation Of T Cell Activation
Chaperone-mediated Protein Complex Assembly
Protein Maturation
Biological Process Involved In Interaction With Symbiont
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
HATs acetylate histones
HATs acetylate histones
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Ub-specific processing proteases
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Deposition of new CENPA-containing nucleosomes at the centromere
G2/M DNA damage checkpoint
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
HCMV Early Events
HCMV Late Events
Transcriptional regulation of granulopoiesis
Inhibition of DNA recombination at telomere
Amyloid fiber formation
Mitochondrial protein import
Mitochondrial protein import
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation
Drugs
Copper
Diseases
Hereditary spastic paraplegia (SPG)
Hypomyelinating leukodystrophy (HLD); Pelizaeus-Merzbacher disease (PMD)
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
Schizophrenia (
25056061
29483656
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Interacting Genes
77 interacting genes:
AIRE
AKT1
ANP32A
AP2M1
ARID1B
ATF2
ATXN7L3
BARD1
BRD2
BRD7
CDK9
CREBBP
DNMT3L
DYRK2
EP300
GADD45A
GATAD2A
GATAD2B
GZMA
H2AC20
HDAC2
HIPK2
HIRA
HIRIP3
HSPD1
IL33
IL7R
KAT2A
KAT2B
KPNA1
LALBA
LOX
MAP4K4
MDM2
MSL1
MSL2
NAP1L4
NCL
NPM1
PARP10
PBRM1
PELP1
PRMT6
PTMA
RAG1
RCC1
RNF168
RNF20
RNF8
RPS6KA5
SAP30
SART3
SIRT7
SMARCA4
SMU1
SPANXN2
SSRP1
STK38
STK4
TAF1A
TAF1B
TBL1X
TBL1XR1
TCF20
TGM2
TNPO1
TRAF6
TSPY1
UBC
UBE2A
USP12
USP15
USP22
USP46
USP49
USP8
VRK1
54 interacting genes:
ALDH2
APP
BAK1
BRCA1
CA2
CASP3
CASP9
CEP70
CLEC7A
CLU
CYSRT1
DHFR
DUX4
ERBB2
ERG
FAM107A
FHIT
H2BC21
HSPE1
ITGA3
ITGB1
KRT31
KRT34
KRT40
KRTAP10-3
KRTAP10-8
KRTAP5-9
LINC01554
LRRK2
LZTS2
MAPK6
MCPH1
NOS1AP
NOTCH2NLA
NR3C1
PLCG2
PLG
PPP2R1A
PPP2R1B
PRKACA
PRNP
PTEN
PTPN11
RASA1
RGS20
SAMD3
SUMO2
SUMO4
SUPT6H
TLR1
TMCC2
TRIM63
UBASH3A
YWHAG
Entrez ID
8349
3329
HPRD ID
03494
00318
Ensembl ID
ENSG00000184678
ENSG00000144381
Uniprot IDs
Q16778
A0A024R3X4
P10809
PDB IDs
4NFT
6A7U
6KBB
6M4D
6M4G
6M4H
4PJ1
6HT7
6MRC
6MRD
Enriched GO Terms of Interacting Partners
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