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SIRT7 and H2AC20
Data Source:
BioGRID
(pull down)
SIRT7
H2AC20
Description
sirtuin 7
H2A clustered histone 20
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Nucleolus
Nucleolus Organizer Region
Cytoplasm
Nuclear Speck
Site Of Double-strand Break
Nucleosome
Nucleus
Extracellular Exosome
Molecular Function
Chromatin Binding
Transcription Corepressor Activity
Histone Deacetylase Activity
Protein Binding
Deacetylase Activity
NAD-dependent Protein Deacetylase Activity
Protein-succinyllysine Desuccinylase Activity
Metal Ion Binding
Protein-glutaryllysine Deglutarylase Activity
NAD+ Binding
NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)
Protein-propionyllysine Depropionylase Activity
Molecular_function
DNA Binding
Protein Heterodimerization Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Osteoblast Differentiation
Regulation Of Gluconeogenesis
DNA Repair
Regulation Of DNA Repair
Protein Deacetylation
Cellular Response To DNA Damage Stimulus
Positive Regulation Of Transcription Involved In Exit From Mitosis
Homologous Chromosome Pairing At Meiosis
RRNA Transcription
Negative Regulation Of Transposition
Regulation Of Mitochondrion Organization
Histone Modification
Negative Regulation Of Protein Ubiquitination
Peptidyl-lysine Desuccinylation
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Protein Export From Nucleus
Protein Deglutarylation
Peptidyl-lysine Deglutarylation
R-loop Disassembly
Histone H3 Deacetylation
Histone H4 Deacetylation
Protein Depropionylation
Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I
Histone Glutamine Methylation
Positive Regulation Of RRNA Processing
Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Chromatin Silencing
Biological_process
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
HATs acetylate histones
HATs acetylate histones
RMTs methylate histone arginines
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
UCH proteinases
Ub-specific processing proteases
Metalloprotease DUBs
Deposition of new CENPA-containing nucleosomes at the centromere
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
HCMV Early Events
HCMV Late Events
Transcriptional regulation of granulopoiesis
Inhibition of DNA recombination at telomere
Amyloid fiber formation
Drugs
Diseases
GWAS
Interacting Genes
12 interacting genes:
APP
DDB1
FBL
H2AC20
H2BC21
H3C1
H4C1
MAGED1
POLR1E
RRP9
USP7
WDR77
74 interacting genes:
ANP32A
APP
ATXN7L3
BAP1
BARD1
BMI1
BRCA1
CDY1
CRP
CSTF1
CTCFL
DDB2
DNMT3L
EIF2AK2
EP300
ESR1
FBL
GATAD2A
GATAD2B
H2BC1
H2BC21
H3C1
H4C1
H4C14
HAT1
HDAC2
KAT2A
KAT2B
KAT5
KAT7
MSL2
MYSM1
NAA40
NAP1L4
NCAPH
NCL
NPM1
PARP10
PBRM1
PELP1
POT1
PRMT5
PRMT7
RAG1
RBBP4
RCC1
RNF168
RNF2
RNF20
RNF8
SART3
SIRT7
SSRP1
STK38
TAF15
TAF1A
TAF1B
TCF20
TRIM37
TSPY1
TSSK6
UBC
UBE2B
UBR2
UIMC1
USP10
USP12
USP16
USP2
USP22
USP46
USP51
USP7
USP8
Entrez ID
51547
8338
HPRD ID
12094
09107
Ensembl ID
ENSG00000187531
ENSG00000184260
Uniprot IDs
Q9NRC8
Q16777
PDB IDs
5IQZ
6G0S
6Y5E
Enriched GO Terms of Interacting Partners
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