Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
H2BC21 and TRAF6
Data Source:
BioGRID
(enzymatic study)
H2BC21
TRAF6
Description
H2B clustered histone 21
TNF receptor associated factor 6
Image
GO Annotations
Cellular Component
Nucleosome
Extracellular Space
Nucleus
Nucleoplasm
Cytosol
Extracellular Exosome
Nucleus
Cytoplasm
Lipid Droplet
Cytosol
Plasma Membrane
Cell Cortex
Cytoplasmic Side Of Plasma Membrane
Endosome Membrane
Protein-containing Complex
CD40 Receptor Complex
Perinuclear Region Of Cytoplasm
Plasma Membrane Signaling Receptor Complex
Molecular Function
DNA Binding
Protein Binding
Protein Heterodimerization Activity
Ubiquitin-protein Transferase Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Zinc Ion Binding
Protein Kinase Binding
Mitogen-activated Protein Kinase Kinase Kinase Binding
Ubiquitin Conjugating Enzyme Binding
Ubiquitin Protein Ligase Binding
Thioesterase Binding
Identical Protein Binding
Histone Deacetylase Binding
Protein Kinase B Binding
Protein N-terminus Binding
Ubiquitin Protein Ligase Activity
Biological Process
Innate Immune Response In Mucosa
Nucleosome Assembly
Antibacterial Humoral Response
Defense Response To Gram-positive Bacterium
Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Negative Regulation Of Transcription By RNA Polymerase II
Activation Of MAPK Activity
Protein Polyubiquitination
Ossification
In Utero Embryonic Development
Neural Tube Closure
Stimulatory C-type Lectin Receptor Signaling Pathway
Toll-like Receptor Signaling Pathway
Regulation Of Immunoglobulin Production
Positive Regulation Of T Cell Cytokine Production
MyD88-dependent Toll-like Receptor Signaling Pathway
Cellular Response To DNA Damage Stimulus
I-kappaB Kinase/NF-kappaB Signaling
Activation Of NF-kappaB-inducing Kinase Activity
JNK Cascade
Protein Deubiquitination
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Osteoclast Differentiation
Membrane Protein Intracellular Domain Proteolysis
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway
Activation Of Protein Kinase Activity
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Interleukin-6 Production
Tumor Necrosis Factor-mediated Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
T-helper 1 Type Immune Response
Positive Regulation Of T Cell Proliferation
Odontogenesis Of Dentin-containing Tooth
Myeloid Dendritic Cell Differentiation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of JUN Kinase Activity
Bone Resorption
Positive Regulation Of Osteoclast Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of JNK Cascade
Cell Development
Positive Regulation Of Smooth Muscle Cell Proliferation
T Cell Receptor Signaling Pathway
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein Autoubiquitination
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Protein K63-linked Ubiquitination
Response To Interleukin-1
Cellular Response To Lipopolysaccharide
Cellular Response To Cytokine Stimulus
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Positive Regulation Of Transcription Regulatory Region DNA Binding
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
HATs acetylate histones
HATs acetylate histones
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Ub-specific processing proteases
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Deposition of new CENPA-containing nucleosomes at the centromere
G2/M DNA damage checkpoint
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
HCMV Early Events
HCMV Late Events
Transcriptional regulation of granulopoiesis
Inhibition of DNA recombination at telomere
Amyloid fiber formation
PIP3 activates AKT signaling
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
Regulated proteolysis of p75NTR
Downstream TCR signaling
NRIF signals cell death from the nucleus
NRIF signals cell death from the nucleus
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
FCERI mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
CLEC7A (Dectin-1) signaling
Ub-specific processing proteases
Ovarian tumor domain proteases
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
TICAM1,TRAF6-dependent induction of TAK1 complex
Interleukin-1 signaling
TRAF6 mediated IRF7 activation
TRAF6 mediated NF-kB activation
TRAF6 mediated NF-kB activation
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
IRAK2 mediated activation of TAK1 complex
TRAF6-mediated induction of TAK1 complex within TLR4 complex
Alpha-protein kinase 1 signaling pathway
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
MyD88 dependent cascade initiated on endosome
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
MyD88 cascade initiated on plasma membrane
Drugs
Diseases
GWAS
Idiopathic inflammatory myopathy (
26362759
)
Metabolite levels (
23823483
)
Rheumatoid arthritis (
30423114
24390342
)
Interacting Genes
77 interacting genes:
AIRE
AKT1
ANP32A
AP2M1
ARID1B
ATF2
ATXN7L3
BARD1
BRD2
BRD7
CDK9
CREBBP
DNMT3L
DYRK2
EP300
GADD45A
GATAD2A
GATAD2B
GZMA
H2AC20
HDAC2
HIPK2
HIRA
HIRIP3
HSPD1
IL33
IL7R
KAT2A
KAT2B
KPNA1
LALBA
LOX
MAP4K4
MDM2
MSL1
MSL2
NAP1L4
NCL
NPM1
PARP10
PBRM1
PELP1
PRMT6
PTMA
RAG1
RCC1
RNF168
RNF20
RNF8
RPS6KA5
SAP30
SART3
SIRT7
SMARCA4
SMU1
SPANXN2
SSRP1
STK38
STK4
TAF1A
TAF1B
TBL1X
TBL1XR1
TCF20
TGM2
TNPO1
TRAF6
TSPY1
UBC
UBE2A
USP12
USP15
USP22
USP46
USP49
USP8
VRK1
174 interacting genes:
ABL1
APP
ATM
ATP6V1E1
ATXN3
BANK1
BCL3
BEX3
BMPR1B
BRSK2
CALCOCO2
CASP8
CAV1
CBL
CD40
CUL5
CYLD
DLG4
DNA2
ECSIT
EDA2R
EDARADD
FHL2
FYN
GART
GSK3B
GTF2I
H2AX
H2BC21
HNRNPA1
HSD17B10
HSPA4
IL17RB
IPMK
IQUB
IRAK1
IRAK2
IRAK3
IRAK4
IRF5
IRF7
IRF8
JAK2
KCNQ1
LIMD1
LNX1
MALT1
MAP2K1
MAP2K6
MAP2K7
MAP3K11
MAP3K14
MAP3K3
MAP3K5
MAP3K7
MAP3K8
MAPK14
MAPK8
MAPT
MAST2
MATR3
MAVS
MBP
MCL1
MEOX2
MTOR
MTURN
NEAT1
NGFR
NTRK1
NTRK2
NUMBL
OTUB1
OTUB2
OTUD7B
PEDS1-UBE2V1
PELI3
PFN1
PINK1
PLEKHF2
PLEKHO1
POLI
PPP4C
PRKCZ
PSMB5
PSMC1
PSMC2
PSMC3
PSMD1
PSMD12
PSMD13
PSMD6
PSMD7
PTPN6
RAD23A
RIPK2
RNF114
RNF31
RPL3
RPS2
RPS20
RPS27A
SIGIRR
SPHK1
SPOP
SQSTM1
SRC
STAMBP
STK26
STRADB
STUB1
SYK
TAB1
TAB2
TAB3
TANK
TAX1BP1
TDP2
TGFBR1
TICAM1
TICAM2
TIFA
TIRAP
TLR3
TNFAIP3
TNFRSF11A
TNFRSF13B
TNFRSF19
TNFSF11
TRAF1
TRAF2
TRAF3IP1
TRAF3IP2
TRAF4
TRAF5
TRAF7
TRAFD1
TRAM1
TRIM17
TRIM25
TRIM37
TXNIP
UBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2I
UBE2L3
UBE2N
UBE2V1
UBOX5
UBTD1
UBXN7
UEVLD
USP1
USP15
USP2
USP21
USP39
USP7
VPS52
XIAP
YBX1
YES1
YOD1
YWHAQ
ZBTB25
ZFAND5
ZMYND11
ZNF675
ZRANB1
Entrez ID
8349
7189
HPRD ID
03494
03833
Ensembl ID
ENSG00000184678
ENSG00000175104
Uniprot IDs
Q16778
Q9Y4K3
PDB IDs
4NFT
6A7U
6KBB
6M4D
6M4G
6M4H
1LB4
1LB5
1LB6
2ECI
2JMD
3HCS
3HCT
3HCU
4Z8M
5ZUJ
6A33
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?