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H2BC21 and USP8
Data Source:
BioGRID
(enzymatic study)
H2BC21
USP8
Description
H2B clustered histone 21
ubiquitin specific peptidase 8
Image
GO Annotations
Cellular Component
Nucleosome
Extracellular Space
Nucleus
Nucleoplasm
Cytosol
Extracellular Exosome
Nucleus
Cytoplasm
Early Endosome
Cytosol
Postsynaptic Density
Extrinsic Component Of Plasma Membrane
Midbody
Extrinsic Component Of Endosome Membrane
Dendritic Spine
Glutamatergic Synapse
Molecular Function
DNA Binding
Protein Binding
Protein Heterodimerization Activity
Cysteine-type Endopeptidase Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
SH3 Domain Binding
Cadherin Binding
Biological Process
Innate Immune Response In Mucosa
Nucleosome Assembly
Antibacterial Humoral Response
Defense Response To Gram-positive Bacterium
Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Mitotic Cytokinesis
Ubiquitin-dependent Protein Catabolic Process
Endosome Organization
Ras Protein Signal Transduction
Protein Deubiquitination
Protein Phosphopantetheinylation
Regulation Of Protein Stability
Regulation Of Protein Localization
Protein K63-linked Deubiquitination
Protein K48-linked Deubiquitination
Cellular Response To Dexamethasone Stimulus
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission
Cellular Response To Nerve Growth Factor Stimulus
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
HATs acetylate histones
HATs acetylate histones
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Ub-specific processing proteases
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Deposition of new CENPA-containing nucleosomes at the centromere
G2/M DNA damage checkpoint
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
HCMV Early Events
HCMV Late Events
Transcriptional regulation of granulopoiesis
Inhibition of DNA recombination at telomere
Amyloid fiber formation
Downregulation of ERBB2:ERBB3 signaling
Regulation of FZD by ubiquitination
Ub-specific processing proteases
Negative regulation of MET activity
Drugs
Diseases
GWAS
Ankylosing spondylitis (
30946743
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Heel bone mineral density (
30598549
)
Mean reticulocyte volume (
32888494
)
Monocyte percentage of white cells (
32888494
)
Interacting Genes
77 interacting genes:
AIRE
AKT1
ANP32A
AP2M1
ARID1B
ATF2
ATXN7L3
BARD1
BRD2
BRD7
CDK9
CREBBP
DNMT3L
DYRK2
EP300
GADD45A
GATAD2A
GATAD2B
GZMA
H2AC20
HDAC2
HIPK2
HIRA
HIRIP3
HSPD1
IL33
IL7R
KAT2A
KAT2B
KPNA1
LALBA
LOX
MAP4K4
MDM2
MSL1
MSL2
NAP1L4
NCL
NPM1
PARP10
PBRM1
PELP1
PRMT6
PTMA
RAG1
RCC1
RNF168
RNF20
RNF8
RPS6KA5
SAP30
SART3
SIRT7
SMARCA4
SMU1
SPANXN2
SSRP1
STK38
STK4
TAF1A
TAF1B
TBL1X
TBL1XR1
TCF20
TGM2
TNPO1
TRAF6
TSPY1
UBC
UBE2A
USP12
USP15
USP22
USP46
USP49
USP8
VRK1
40 interacting genes:
BACE1
BIRC6
CFLAR
CHMP1A
CHMP1B
CHMP2A
CHMP2B
CHMP4C
CHMP7
DNAJB6
EPS15
GRAP2
GRB2
H2AC20
H2BC21
KIF23
NBR1
PJA1
PLA2G2A
RASGRF1
RNF41
SEC31A
SHANK1
SHANK3
SLBP
SNCA
SPP1
SRC
STAM
STAM2
TRIM54
TRIM55
TRIM63
UBC
USP15
USP21
USP28
YWHAG
YWHAQ
YWHAZ
Entrez ID
8349
9101
HPRD ID
03494
04405
Ensembl ID
ENSG00000184678
ENSG00000138592
Uniprot IDs
Q16778
A0A024R5S4
A8K8N5
P40818
PDB IDs
4NFT
6A7U
6KBB
6M4D
6M4G
6M4H
1WHB
2A9U
2GFO
2GWF
3N3K
6F09
Enriched GO Terms of Interacting Partners
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