SIRT7 and POLR1E

Data Source:
BioGRID (pull down, affinity chromatography technology)

		SIRT7	POLR1E
Description		sirtuin 7	RNA polymerase I subunit E
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Nucleolus Organizer Region Cytoplasm Nuclear Speck Site Of Double-strand Break	Fibrillar Center Nucleoplasm Nucleolus RNA Polymerase I Complex
	Molecular Function	Chromatin Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Deacetylase Activity NAD-dependent Protein Deacetylase Activity Protein-succinyllysine Desuccinylase Activity Metal Ion Binding Protein-glutaryllysine Deglutarylase Activity NAD+ Binding NAD-dependent Histone Deacetylase Activity (H3-K18 Specific) Protein-propionyllysine Depropionylase Activity	RNA Polymerase I General Transcription Initiation Factor Binding DNA Binding DNA-directed 5'-3' RNA Polymerase Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Regulation Of Gluconeogenesis DNA Repair Regulation Of DNA Repair Protein Deacetylation Cellular Response To DNA Damage Stimulus Positive Regulation Of Transcription Involved In Exit From Mitosis Homologous Chromosome Pairing At Meiosis RRNA Transcription Negative Regulation Of Transposition Regulation Of Mitochondrion Organization Histone Modification Negative Regulation Of Protein Ubiquitination Peptidyl-lysine Desuccinylation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Export From Nucleus Protein Deglutarylation Peptidyl-lysine Deglutarylation R-loop Disassembly Histone H3 Deacetylation Histone H4 Deacetylation Protein Depropionylation Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Histone Glutamine Methylation Positive Regulation Of RRNA Processing Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	RNA Polymerase I Preinitiation Complex Assembly Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Nucleolar Large RRNA Transcription By RNA Polymerase I Positive Regulation Of Gene Expression, Epigenetic
Pathways			NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination
Drugs
Diseases
GWAS
Interacting Genes		12 interacting genes: APP DDB1 FBL H2AC20 H2BC21 H3C1 H4C1 MAGED1 POLR1E RRP9 USP7 WDR77	8 interacting genes: NFKBIB POLR1A POLR1B POLR1C POLR1G SIRT7 TAF1C UBTF
Entrez ID		51547	64425
HPRD ID		12094	15096
Ensembl ID		ENSG00000187531	ENSG00000137054
Uniprot IDs		Q9NRC8	B4E005 Q9GZS1
PDB IDs		5IQZ 6G0S
Enriched GO Terms of Interacting Partners?
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