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SCN3B and GIMAP5
Data Source:
BioGRID
(two hybrid)
SCN3B
GIMAP5
Description
sodium voltage-gated channel beta subunit 3
GTPase, IMAP family member 5
Image
No pdb structure
GO Annotations
Cellular Component
Voltage-gated Sodium Channel Complex
Plasma Membrane
Integral Component Of Membrane
Z Disc
Lysosomal Membrane
Integral Component Of Membrane
Multivesicular Body Membrane
Molecular Function
Voltage-gated Ion Channel Activity
Protein Binding
Sodium Channel Regulator Activity
Sodium Channel Inhibitor Activity
Ion Channel Binding
Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential
Protein Binding
GTP Binding
Biological Process
Sodium Ion Transport
Nervous System Development
Positive Regulation Of Heart Rate
Positive Regulation Of Sodium Ion Transport
Sensory Perception Of Pain
Sodium Ion Transmembrane Transport
Membrane Depolarization
Cardiac Muscle Contraction
Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization
Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization
Protein Localization To Plasma Membrane
Cardiac Muscle Cell Action Potential Involved In Contraction
Ventricular Cardiac Muscle Cell Action Potential
Membrane Depolarization During Action Potential
Membrane Depolarization During Cardiac Muscle Cell Action Potential
Atrial Cardiac Muscle Cell Action Potential
SA Node Cell Action Potential
Regulation Of Heart Rate By Cardiac Conduction
Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways
Interaction between L1 and Ankyrins
Phase 0 - rapid depolarisation
Drugs
Ranolazine
Valproic acid
Oxcarbazepine
Cocaine
Zonisamide
Brivaracetam
Dichlorobenzyl alcohol
Fish oil
Diseases
Brugada syndrome (BRS)
GWAS
Chronic lymphocytic leukemia (
28165464
24292274
23770605
)
Response to citalopram or escitalopram in depression (
27622933
)
Interacting Genes
105 interacting genes:
ADIPOQ
AGPAT4
AGPAT5
ANKRD46
AQP10
ARV1
ATP13A1
ATP6V0C
BNIP1
BNIP3
BRICD5
CLCA4
CTXN3
CYP4F2
DEFB103A
DEFB103B
DERL1
DGAT2L6
ERG28
FAM241B
FAM3C
FIS1
FKBP8
FXYD3
GIMAP1
GIMAP5
GPR151
GPR61
IER3IP1
INSIG2
ISM2
ITGAM
LEMD1
LEPROTL1
LPAR3
MAL2
MARCHF2
MFSD5
MGST3
MS4A13
NFASC
NINJ2
ORMDL1
ORMDL2
PLBD2
PLP2
PLPPR2
PMP22
RHD
RNF8
RUSF1
SACM1L
SCD
SEC22A
SERP2
SFT2D1
SFXN1
SFXN3
SLC2A5
SLC30A3
SLC30A8
SLC35A4
SLC35E4
SLC38A1
SLC38A7
SLC7A1
SMCO4
SMIM1
STRIT1
STX3
STX6
STX8
THSD7A
TIMM23
TM6SF2
TMBIM6
TMEM120A
TMEM120B
TMEM128
TMEM140
TMEM14A
TMEM14B
TMEM208
TMEM239
TMEM243
TMEM42
TMEM50B
TMEM60
TMEM65
TMEM86A
TMPPE
TPRG1
TRARG1
TSPAN2
TVP23B
UBIAD1
USE1
VAMP1
VAMP2
VAMP3
VAPA
VAPB
YIF1A
YIPF4
ZFPL1
64 interacting genes:
ADGRG3
APP
AQP3
AQP6
ARL13B
BTNL9
CD33
CD53
CLDN7
CREB3L1
CYB561
CYBRD1
DKK4
EBP
EDA
EDA2R
ELOVL4
EMP1
ERGIC3
EVI2B
FAM174A
FAM210B
FATE1
FCER1G
GJA8
GJB3
GORAB
GRAMD2B
IFNGR2
JAGN1
KASH5
KIR3DL3
LAYN
LDLRAD1
LSMEM2
M6PR
MGST2
MGST3
MILR1
MS4A14
PDZK1IP1
PTGES
RETREG3
RNASEK
RNF19B
SCN3B
SHISAL1
SLC10A1
SLC35C2
SMIM3
SPACA1
STOM
STX1A
STX2
STX4
SYT1
TM4SF18
TM4SF19
TMEM31
TMX1
TMX2
TNFRSF19
TSPAN18
ZFYVE27
Entrez ID
55800
55340
HPRD ID
10497
16280
Ensembl ID
ENSG00000166257
ENSG00000196329
Uniprot IDs
A0A024R3H7
Q9NY72
A0A090N8P9
Q96F15
PDB IDs
4L1D
Enriched GO Terms of Interacting Partners
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