PAK3 and GIT1

Data Source:
HPRD (in vivo)

		PAK3	GIT1
Description		p21 (RAC1) activated kinase 3	GIT ArfGAP 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Cytosol Plasma Membrane Postsynaptic Density Glutamatergic Synapse	Mitochondrion Cytosol Focal Adhesion Membrane Calyx Of Held
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding SH3 Domain Binding Small GTPase Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	GTPase Activator Activity Protein Binding Protein-containing Complex Binding Metal Ion Binding
	Biological Process	MAPK Cascade Activation Of MAPK Activity Stimulatory C-type Lectin Receptor Signaling Pathway Protein Phosphorylation Axonogenesis Positive Regulation Of Fibroblast Migration Dendrite Development Regulation Of Actin Filament Polymerization Stress-activated Protein Kinase Signaling Cascade T Cell Costimulation Activation Of Protein Kinase Activity Positive Regulation Of Neuron Apoptotic Process Ephrin Receptor Signaling Pathway Regulation Of Axonogenesis Synapse Organization T Cell Receptor Signaling Pathway Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Morphogenesis Cellular Response To Organic Cyclic Compound Positive Regulation Of DNA Biosynthetic Process	Intramembranous Ossification Brain Development Locomotory Behavior Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Cytokinesis Negative Regulation Of Interleukin-1 Beta Production Positive Regulation Of GTPase Activity Cell Redox Homeostasis Negative Regulation Of Glycolytic Process Ephrin Receptor Signaling Pathway Neuron Development Motor Learning Cellular Response To Lipopolysaccharide Presynaptic Modulation Of Chemical Synaptic Transmission Negative Regulation Of Inflammatory Response To Wounding Regulation Of Synaptic Vesicle Exocytosis
Pathways		Generation of second messenger molecules CD28 dependent Vav1 pathway Ephrin signaling Sema3A PAK dependent Axon repulsion Activation of RAC1 VEGFR2 mediated vascular permeability CD209 (DC-SIGN) signaling RHO GTPases activate PAKs RHO GTPases activate PAKs MAPK6/MAPK4 signaling	Ephrin signaling Ephrin signaling Activation of RAC1 downstream of NMDARs
Drugs		Fostamatinib
Diseases		Non-syndromic X-linked mental retardation
GWAS			Adult body size ( 32376654) Brain morphology (MOSTest) ( 32665545)
Interacting Genes		13 interacting genes: ARHGEF6 ARHGEF7 CDC42 GIT1 GIT2 MYO6 NCK1 PXN RAC1 RAF1 RHOJ SNCA SYN1	52 interacting genes: ARHGEF6 ARHGEF7 BARD1 C8orf33 CCDC113 CDC42 CENPU CEP126 CHD3 DDX24 EIF6 ENTR1 GIT2 GRB2 GRK2 GRK3 GRK5 GRK6 HAP1 HMOX2 HTT KIF1A LAMTOR5 LPXN LRIF1 MAN2A2 NEK2 PAK3 PCLO PDPK1 PFDN1 PLCG1 PMF1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 PTK2 PTPRZ1 PXN RAN RGS2 RIF1 SRC SRRT TAB1 TERF1 TGFB1I1 TRIB3 TXNDC9 WDR33 YWHAG
Entrez ID		5063	28964
HPRD ID		02142	06577
Ensembl ID		ENSG00000077264	ENSG00000108262
Uniprot IDs		B2RCU6 O75914	Q59FC3 Q9Y2X7
PDB IDs		6FD3
Enriched GO Terms of Interacting Partners?
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