PAK3 and GIT2

Data Source:
HPRD (in vivo)

		PAK3	GIT2
Description		p21 (RAC1) activated kinase 3	GIT ArfGAP 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Cytosol Plasma Membrane Postsynaptic Density Glutamatergic Synapse	Nucleoplasm Focal Adhesion
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding SH3 Domain Binding Small GTPase Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	GTPase Activator Activity Protein Binding Metal Ion Binding
	Biological Process	MAPK Cascade Activation Of MAPK Activity Stimulatory C-type Lectin Receptor Signaling Pathway Protein Phosphorylation Axonogenesis Positive Regulation Of Fibroblast Migration Dendrite Development Regulation Of Actin Filament Polymerization Stress-activated Protein Kinase Signaling Cascade T Cell Costimulation Activation Of Protein Kinase Activity Positive Regulation Of Neuron Apoptotic Process Ephrin Receptor Signaling Pathway Regulation Of Axonogenesis Synapse Organization T Cell Receptor Signaling Pathway Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Morphogenesis Cellular Response To Organic Cyclic Compound Positive Regulation Of DNA Biosynthetic Process	Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of GTPase Activity
Pathways		Generation of second messenger molecules CD28 dependent Vav1 pathway Ephrin signaling Sema3A PAK dependent Axon repulsion Activation of RAC1 VEGFR2 mediated vascular permeability CD209 (DC-SIGN) signaling RHO GTPases activate PAKs RHO GTPases activate PAKs MAPK6/MAPK4 signaling
Drugs		Fostamatinib
Diseases		Non-syndromic X-linked mental retardation
GWAS			Bipolar disorder ( 31043756) Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia ( 28922980) Metabolic syndrome ( 20694148) Metabolite levels ( 23823483) Metabolite levels (MHPG) ( 23319000)
Interacting Genes		13 interacting genes: ARHGEF6 ARHGEF7 CDC42 GIT1 GIT2 MYO6 NCK1 PXN RAC1 RAF1 RHOJ SNCA SYN1	48 interacting genes: ACTG1 ACTN1 ARHGEF6 ARHGEF7 ATF5 C4BPA CALCOCO2 CDC42 CORO1A E2F2 EDC4 GCH1 GET4 GIT1 GRK2 GUSB HGD HNRNPUL1 IKBKG KCTD5 KRT18 LAMTOR5 LMNB1 MVP NFKBIB NME2 PAK1 PAK3 PCLO POLR1B PROX1 PXN QPRT RCVRN RUFY1 RUSC2 SAFB2 SH3GLB2 SMAD3 SPOP TGFB1I1 TNFAIP3 TNIP1 TRAF1 TSN UBQLN1 USHBP1 YWHAG
Entrez ID		5063	9815
HPRD ID		02142	09779
Ensembl ID		ENSG00000077264	ENSG00000139436
Uniprot IDs		B2RCU6 O75914	F8VXI9 F8W822 Q14161 Q68DM7 Q6FI58
PDB IDs		6FD3
Enriched GO Terms of Interacting Partners?
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