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RAF1 and NRAS
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vitro)
RAF1
NRAS
Description
Raf-1 proto-oncogene, serine/threonine kinase
NRAS proto-oncogene, GTPase
Image
GO Annotations
Cellular Component
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Golgi Apparatus
Cytosol
Plasma Membrane
Nuclear Speck
Pseudopodium
Golgi Membrane
Golgi Apparatus
Plasma Membrane
Membrane
Extracellular Exosome
Tertiary Granule Membrane
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Kinase Activity
Protein Binding
ATP Binding
Adenylate Cyclase Binding
Adenylate Cyclase Activator Activity
Enzyme Binding
Small GTPase Binding
Mitogen-activated Protein Kinase Kinase Binding
Identical Protein Binding
Protein-containing Complex Binding
Metal Ion Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
GTPase Activity
Protein Binding
GTP Binding
GDP Binding
Protein-containing Complex Binding
Biological Process
MAPK Cascade
Activation Of MAPKK Activity
Response To Hypoxia
Stimulatory C-type Lectin Receptor Signaling Pathway
Protein Phosphorylation
Apoptotic Process
Signal Transduction
Activation Of Adenylate Cyclase Activity
Heart Development
Negative Regulation Of Cell Population Proliferation
Cell Differentiation
Platelet Activation
Thyroid Gland Development
Negative Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Peptidyl-serine Phosphorylation
Ion Transmembrane Transport
Somatic Stem Cell Population Maintenance
Regulation Of Rho Protein Signal Transduction
Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Response To Muscle Stretch
Wound Healing
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Intermediate Filament Cytoskeleton Organization
Regulation Of Cell Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Neurotrophin TRK Receptor Signaling Pathway
Thymus Development
Face Development
Death-inducing Signaling Complex Assembly
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Regulation Of Cell Motility
MAPK Cascade
Positive Regulation Of Endothelial Cell Proliferation
Stimulatory C-type Lectin Receptor Signaling Pathway
Ras Protein Signal Transduction
Neutrophil Degranulation
Pathways
Stimuli-sensing channels
Rap1 signalling
GP1b-IX-V activation signalling
CD209 (DC-SIGN) signaling
RAF activation
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway
Negative regulation of MAPK pathway
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Signaling by MRAS-complex mutants
SOS-mediated signalling
Activation of RAS in B cells
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
SHC1 events in ERBB2 signaling
SHC1 events in ERBB4 signaling
Signaling by SCF-KIT
Signalling to RAS
p38MAPK events
p38MAPK events
GRB2 events in EGFR signaling
SHC1 events in EGFR signaling
Downstream signal transduction
GRB2 events in ERBB2 signaling
GRB2 events in ERBB2 signaling
Tie2 Signaling
EGFR Transactivation by Gastrin
DAP12 signaling
SHC-related events triggered by IGF1R
FCERI mediated MAPK activation
NCAM signaling for neurite out-growth
Ras activation upon Ca2+ influx through NMDA receptor
VEGFR2 mediated cell proliferation
CD209 (DC-SIGN) signaling
Constitutive Signaling by EGFRvIII
SHC-mediated cascade:FGFR1
FRS-mediated FGFR1 signaling
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
Regulation of RAS by GAPs
RAF activation
RAF/MAP kinase cascade
MAP2K and MAPK activation
Negative regulation of MAPK pathway
Neutrophil degranulation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
RAS signaling downstream of NF1 loss-of-function variants
Paradoxical activation of RAF signaling by kinase inactive BRAF
Insulin receptor signalling cascade
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
MET activates RAS signaling
Signaling by FGFR3 fusions in cancer
Signaling by FGFR3 point mutants in cancer
Activated NTRK2 signals through RAS
Erythropoietin activates RAS
Activated NTRK2 signals through FRS2 and FRS3
Activated NTRK3 signals through RAS
FLT3 Signaling
Constitutive Signaling by Overexpressed ERBB2
Estrogen-stimulated signaling through PRKCZ
RAS processing
RAS GTPase cycle mutants
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Signaling by FLT3 fusion proteins
Signaling by FLT3 ITD and TKD mutants
Drugs
Sorafenib
LErafAON
XL281
iCo-007
Cholecystokinin
Regorafenib
Dabrafenib
Fostamatinib
Diseases
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
Oral cancer
Acute myeloid leukemia (AML)
Multiple myeloma
Adrenal carcinoma
Thyroid cancer
Hepatocellular carcinoma
Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
Malignant melanoma
GWAS
Asthma (
32296059
)
Cardiac hypertrophy (
21348951
)
Carotid intima media thickness x smoking interaction (
32117412
)
Cholesterol, total (
24097068
20686565
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
HDL cholesterol levels (
32203549
)
Total cholesterol levels (
28334899
)
Waist-to-hip ratio adjusted for BMI (
26426971
)
Waist-to-hip ratio adjusted for BMI (age <50) (
26426971
)
Waist-to-hip ratio adjusted for BMI (age >50) (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Adult body size (
32376654
)
Autism (
24189344
)
Interacting Genes
160 interacting genes:
ABCB5
ADCY6
AGTR1
AKT1
AR
ARNT
ARRB2
BAD
BAG1
BCL2
BCL2L1
BCL6
BECN1
BIRC2
BIRC3
BRAF
CASZ1
CBLC
CCND2
CCT3
CD44
CDC25A
CDC37
CDK4
CDK6
CDKN2A
CDKN2B
CDKN2C
CFLAR
CNKSR1
COPS3
COPS7A
CPS1
DCAF8
DMPK
EFEMP1
EGFR
EPHA2
ERBB2
ERBIN
FGFR4
FYCO1
FYN
GLIS2
GNB2
GNG4
GRB10
GRM1
HERC1
HGF
HRAS
HSP90AA1
HSPA4
HSPA8
IL2RB
INSR
INTS10
JAK1
JAK2
KEAP1
KRAS
KRT18
KRT8
KSR1
KSR2
LATS2
LCK
LOX
LRPAP1
MAP2K1
MAP2K2
MAP2K3
MAP2K5
MAP2K6
MAP3K1
MAP3K5
MAPK1
MAPK3
MAPK7
MAPK8
MAPK8IP3
MBP
MET
MRAS
MRC2
MYBPC1
MYC
NEDD4
NF1
NF2
NPLOC4
NR3C1
NRAS
NUDT14
OIP5
PACSIN3
PAK1
PAK2
PAK3
PBK
PDGFRA
PDGFRB
PDLIM2
PEBP1
PEBP4
PEX5L
PHB
PHKA2
PIN1
PKM
PPP1CC
PPP2CB
PRKAA1
PRKACA
PRKAR1A
PRKCA
PRKCD
PRKCE
PRKCZ
PRKG1
PRPF6
PURA
RANBP9
RAP1A
RAP2A
RASD2
RASSF1
RB1
RBBP8
RBL2
RFXANK
RHEB
RRAS
RRAS2
RSU1
SHOC2
SPRY2
SPRY4
SRC
STK26
STK3
STUB1
TBXA2R
TEAD2
TERT
TIMM50
TMEM70
TSC22D3
UBE2D2
UBE2L3
VAV1
VDAC1
XIAP
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
YY1
48 interacting genes:
ACVR1
AKT1
ALDOB
AOPEP
ARAF
ARHGAP4
BCL2
CCDC180
CORO2A
CYLC2
DNAJB1
EEF1A1
FANCC
FBP2
FRAT2
HEMGN
HRAS
LEF1
LZTR1
MAPK3
MAPKAP1
MTOR
PIK3CA
PIK3CG
PLCE1
PPP2CB
RACGAP1
RAF1
RAP1GDS1
RASA1
RASGRP2
RASSF5
RGL2
RGL3
RIN1
RPS20
SFRP4
SHOC2
SMAD1
SMAD4
SMURF2
SRI
STX17
TDRD7
TRMO
UBE2L3
WDR76
XPA
Entrez ID
5894
4893
HPRD ID
01265
01273
Ensembl ID
ENSG00000132155
ENSG00000213281
Uniprot IDs
A0A0S2Z4L5
L7RRS6
P04049
P01111
Q5U091
PDB IDs
1C1Y
1FAQ
1FAR
1GUA
1RFA
3CU8
3IQJ
3IQU
3IQV
3KUC
3KUD
3NKX
3O8I
3OMV
4FJ3
4G0N
4G3X
4IEA
4IHL
6NTC
6NTD
6PTS
6PTW
7JHP
2N9C
3CON
5UHV
6E6H
6MPP
6ULI
6ULK
6ULN
6ULR
6UON
6WGH
6ZIO
6ZIR
6ZIZ
Enriched GO Terms of Interacting Partners
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