RAF1 and PRKAR1A

Data Source:
BioGRID (two hybrid)

		RAF1	PRKAR1A
Description		Raf-1 proto-oncogene, serine/threonine kinase	protein kinase cAMP-dependent type I regulatory subunit alpha
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Golgi Apparatus Cytosol Plasma Membrane Nuclear Speck Pseudopodium	Immunological Synapse Cytoplasm Multivesicular Body Centrosome Cytosol Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Neuromuscular Junction Protein-containing Complex Plasma Membrane Raft Sperm Connecting Piece Ciliary Base Glutamatergic Synapse
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Adenylate Cyclase Binding Adenylate Cyclase Activator Activity Enzyme Binding Small GTPase Binding Mitogen-activated Protein Kinase Kinase Binding Identical Protein Binding Protein-containing Complex Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Response To Hypoxia Stimulatory C-type Lectin Receptor Signaling Pathway Protein Phosphorylation Apoptotic Process Signal Transduction Activation Of Adenylate Cyclase Activity Heart Development Negative Regulation Of Cell Population Proliferation Cell Differentiation Platelet Activation Thyroid Gland Development Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Peptidyl-serine Phosphorylation Ion Transmembrane Transport Somatic Stem Cell Population Maintenance Regulation Of Rho Protein Signal Transduction Insulin Secretion Involved In Cellular Response To Glucose Stimulus Response To Muscle Stretch Wound Healing Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Intermediate Filament Cytoskeleton Organization Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Neurotrophin TRK Receptor Signaling Pathway Thymus Development Face Development Death-inducing Signaling Complex Assembly Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Cell Motility	Mesoderm Formation Renal Water Homeostasis Regulation Of Transcription By RNA Polymerase II Female Meiotic Nuclear Division Blood Coagulation Regulation Of Protein Kinase A Signaling Activation Of Protein Kinase A Activity Intracellular Signal Transduction Regulation Of CAMP-mediated Signaling Sarcomere Organization Negative Regulation Of Meiotic Nuclear Division Negative Regulation Of Activated T Cell Proliferation Cardiac Muscle Cell Proliferation Cellular Response To Glucagon Stimulus Negative Regulation Of CAMP-dependent Protein Kinase Activity
Pathways		Stimuli-sensing channels Rap1 signalling GP1b-IX-V activation signalling CD209 (DC-SIGN) signaling RAF activation MAP2K and MAPK activation Negative feedback regulation of MAPK pathway Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants Signaling by MRAS-complex mutants	PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production
Drugs		Sorafenib LErafAON XL281 iCo-007 Cholecystokinin Regorafenib Dabrafenib Fostamatinib	(Rp)-cAMPS Cyclic GMP Cyclic adenosine monophosphate GEM-231
Diseases			Pigmented micronodular adrenocortical disease (PPNAD)
GWAS		Asthma ( 32296059) Cardiac hypertrophy ( 21348951) Carotid intima media thickness x smoking interaction ( 32117412) Cholesterol, total ( 24097068 20686565) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) HDL cholesterol levels ( 32203549) Total cholesterol levels ( 28334899) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Body size at age 10 ( 32376654) Coronary artery disease ( 33020668) Estimated glomerular filtration rate ( 31152163) Intake of total sugars ( 31005972)
Interacting Genes		160 interacting genes: ABCB5 ADCY6 AGTR1 AKT1 AR ARNT ARRB2 BAD BAG1 BCL2 BCL2L1 BCL6 BECN1 BIRC2 BIRC3 BRAF CASZ1 CBLC CCND2 CCT3 CD44 CDC25A CDC37 CDK4 CDK6 CDKN2A CDKN2B CDKN2C CFLAR CNKSR1 COPS3 COPS7A CPS1 DCAF8 DMPK EFEMP1 EGFR EPHA2 ERBB2 ERBIN FGFR4 FYCO1 FYN GLIS2 GNB2 GNG4 GRB10 GRM1 HERC1 HGF HRAS HSP90AA1 HSPA4 HSPA8 IL2RB INSR INTS10 JAK1 JAK2 KEAP1 KRAS KRT18 KRT8 KSR1 KSR2 LATS2 LCK LOX LRPAP1 MAP2K1 MAP2K2 MAP2K3 MAP2K5 MAP2K6 MAP3K1 MAP3K5 MAPK1 MAPK3 MAPK7 MAPK8 MAPK8IP3 MBP MET MRAS MRC2 MYBPC1 MYC NEDD4 NF1 NF2 NPLOC4 NR3C1 NRAS NUDT14 OIP5 PACSIN3 PAK1 PAK2 PAK3 PBK PDGFRA PDGFRB PDLIM2 PEBP1 PEBP4 PEX5L PHB PHKA2 PIN1 PKM PPP1CC PPP2CB PRKAA1 PRKACA PRKAR1A PRKCA PRKCD PRKCE PRKCZ PRKG1 PRPF6 PURA RANBP9 RAP1A RAP2A RASD2 RASSF1 RB1 RBBP8 RBL2 RFXANK RHEB RRAS RRAS2 RSU1 SHOC2 SPRY2 SPRY4 SRC STK26 STK3 STUB1 TBXA2R TEAD2 TERT TIMM50 TMEM70 TSC22D3 UBE2D2 UBE2L3 VAV1 VDAC1 XIAP YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ YY1	47 interacting genes: AKAP1 AKAP10 AKAP11 AKAP4 AKAP5 AKAP7 ARFGEF2 BAHD1 C11orf49 C2orf88 CAPN11 CBS CCNE1 CDK2 CDK4 DTX1 EGFR FAM153B GRB2 HIVEP1 HLA-A ITGA4 MAPK6 MYO7A NELL2 PATZ1 PJA2 PLEKHF2 PRKACA PRKAR1B PRKX PRPF40A PYCARD RAF1 RFC2 RSPH3 SET SETD7 SLC2A4 SMAD2 SPART TAB1 TULP3 WDCP WNK1 YWHAZ ZBED1
Entrez ID		5894	5573
HPRD ID		01265	01786
Ensembl ID		ENSG00000132155	ENSG00000108946
Uniprot IDs		A0A0S2Z4L5 L7RRS6 P04049	B2R5T5 P10644
PDB IDs		1C1Y 1FAQ 1FAR 1GUA 1RFA 3CU8 3IQJ 3IQU 3IQV 3KUC 3KUD 3NKX 3O8I 3OMV 4FJ3 4G0N 4G3X 4IEA 4IHL 6NTC 6NTD 6PTS 6PTW 7JHP	5KJX 5KJY 5KJZ
Enriched GO Terms of Interacting Partners?
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