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RAF1 and PAK3
Data Source:
HPRD
(in vivo, in vitro)
RAF1
PAK3
Description
Raf-1 proto-oncogene, serine/threonine kinase
p21 (RAC1) activated kinase 3
Image
GO Annotations
Cellular Component
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Golgi Apparatus
Cytosol
Plasma Membrane
Nuclear Speck
Pseudopodium
Cytoplasm
Endosome
Cytosol
Plasma Membrane
Postsynaptic Density
Glutamatergic Synapse
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Kinase Activity
Protein Binding
ATP Binding
Adenylate Cyclase Binding
Adenylate Cyclase Activator Activity
Enzyme Binding
Small GTPase Binding
Mitogen-activated Protein Kinase Kinase Binding
Identical Protein Binding
Protein-containing Complex Binding
Metal Ion Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Activity
Protein Binding
ATP Binding
SH3 Domain Binding
Small GTPase Binding
Metal Ion Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
MAPK Cascade
Activation Of MAPKK Activity
Response To Hypoxia
Stimulatory C-type Lectin Receptor Signaling Pathway
Protein Phosphorylation
Apoptotic Process
Signal Transduction
Activation Of Adenylate Cyclase Activity
Heart Development
Negative Regulation Of Cell Population Proliferation
Cell Differentiation
Platelet Activation
Thyroid Gland Development
Negative Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Peptidyl-serine Phosphorylation
Ion Transmembrane Transport
Somatic Stem Cell Population Maintenance
Regulation Of Rho Protein Signal Transduction
Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Response To Muscle Stretch
Wound Healing
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Intermediate Filament Cytoskeleton Organization
Regulation Of Cell Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Neurotrophin TRK Receptor Signaling Pathway
Thymus Development
Face Development
Death-inducing Signaling Complex Assembly
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Regulation Of Cell Motility
MAPK Cascade
Activation Of MAPK Activity
Stimulatory C-type Lectin Receptor Signaling Pathway
Protein Phosphorylation
Axonogenesis
Positive Regulation Of Fibroblast Migration
Dendrite Development
Regulation Of Actin Filament Polymerization
Stress-activated Protein Kinase Signaling Cascade
T Cell Costimulation
Activation Of Protein Kinase Activity
Positive Regulation Of Neuron Apoptotic Process
Ephrin Receptor Signaling Pathway
Regulation Of Axonogenesis
Synapse Organization
T Cell Receptor Signaling Pathway
Dendritic Spine Morphogenesis
Positive Regulation Of Dendritic Spine Morphogenesis
Cellular Response To Organic Cyclic Compound
Positive Regulation Of DNA Biosynthetic Process
Pathways
Stimuli-sensing channels
Rap1 signalling
GP1b-IX-V activation signalling
CD209 (DC-SIGN) signaling
RAF activation
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway
Negative regulation of MAPK pathway
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Signaling by MRAS-complex mutants
Generation of second messenger molecules
CD28 dependent Vav1 pathway
Ephrin signaling
Sema3A PAK dependent Axon repulsion
Activation of RAC1
VEGFR2 mediated vascular permeability
CD209 (DC-SIGN) signaling
RHO GTPases activate PAKs
RHO GTPases activate PAKs
MAPK6/MAPK4 signaling
Drugs
Sorafenib
LErafAON
XL281
iCo-007
Cholecystokinin
Regorafenib
Dabrafenib
Fostamatinib
Fostamatinib
Diseases
Non-syndromic X-linked mental retardation
GWAS
Asthma (
32296059
)
Cardiac hypertrophy (
21348951
)
Carotid intima media thickness x smoking interaction (
32117412
)
Cholesterol, total (
24097068
20686565
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
HDL cholesterol levels (
32203549
)
Total cholesterol levels (
28334899
)
Waist-to-hip ratio adjusted for BMI (
26426971
)
Waist-to-hip ratio adjusted for BMI (age <50) (
26426971
)
Waist-to-hip ratio adjusted for BMI (age >50) (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
160 interacting genes:
ABCB5
ADCY6
AGTR1
AKT1
AR
ARNT
ARRB2
BAD
BAG1
BCL2
BCL2L1
BCL6
BECN1
BIRC2
BIRC3
BRAF
CASZ1
CBLC
CCND2
CCT3
CD44
CDC25A
CDC37
CDK4
CDK6
CDKN2A
CDKN2B
CDKN2C
CFLAR
CNKSR1
COPS3
COPS7A
CPS1
DCAF8
DMPK
EFEMP1
EGFR
EPHA2
ERBB2
ERBIN
FGFR4
FYCO1
FYN
GLIS2
GNB2
GNG4
GRB10
GRM1
HERC1
HGF
HRAS
HSP90AA1
HSPA4
HSPA8
IL2RB
INSR
INTS10
JAK1
JAK2
KEAP1
KRAS
KRT18
KRT8
KSR1
KSR2
LATS2
LCK
LOX
LRPAP1
MAP2K1
MAP2K2
MAP2K3
MAP2K5
MAP2K6
MAP3K1
MAP3K5
MAPK1
MAPK3
MAPK7
MAPK8
MAPK8IP3
MBP
MET
MRAS
MRC2
MYBPC1
MYC
NEDD4
NF1
NF2
NPLOC4
NR3C1
NRAS
NUDT14
OIP5
PACSIN3
PAK1
PAK2
PAK3
PBK
PDGFRA
PDGFRB
PDLIM2
PEBP1
PEBP4
PEX5L
PHB
PHKA2
PIN1
PKM
PPP1CC
PPP2CB
PRKAA1
PRKACA
PRKAR1A
PRKCA
PRKCD
PRKCE
PRKCZ
PRKG1
PRPF6
PURA
RANBP9
RAP1A
RAP2A
RASD2
RASSF1
RB1
RBBP8
RBL2
RFXANK
RHEB
RRAS
RRAS2
RSU1
SHOC2
SPRY2
SPRY4
SRC
STK26
STK3
STUB1
TBXA2R
TEAD2
TERT
TIMM50
TMEM70
TSC22D3
UBE2D2
UBE2L3
VAV1
VDAC1
XIAP
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
YY1
13 interacting genes:
ARHGEF6
ARHGEF7
CDC42
GIT1
GIT2
MYO6
NCK1
PXN
RAC1
RAF1
RHOJ
SNCA
SYN1
Entrez ID
5894
5063
HPRD ID
01265
02142
Ensembl ID
ENSG00000132155
ENSG00000077264
Uniprot IDs
A0A0S2Z4L5
L7RRS6
P04049
B2RCU6
O75914
PDB IDs
1C1Y
1FAQ
1FAR
1GUA
1RFA
3CU8
3IQJ
3IQU
3IQV
3KUC
3KUD
3NKX
3O8I
3OMV
4FJ3
4G0N
4G3X
4IEA
4IHL
6NTC
6NTD
6PTS
6PTW
7JHP
6FD3
Enriched GO Terms of Interacting Partners
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