ACO1 and CLTC

Data Source:
BioGRID (two hybrid)

		ACO1	CLTC
Description		aconitase 1	clathrin heavy chain
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Cytosol Extracellular Exosome	Lysosome Endosome Spindle Cytosol Plasma Membrane Focal Adhesion Membrane Clathrin Coat Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Coat Of Coated Pit Clathrin-coated Vesicle Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane Protein-containing Complex Endolysosome Membrane Melanosome Clathrin-coated Endocytic Vesicle Extracellular Exosome Clathrin Complex Mitotic Spindle Extracellular Vesicle Mitotic Spindle Microtubule
	Molecular Function	RNA Binding Aconitate Hydratase Activity Protein Binding Iron-responsive Element Binding Metal Ion Binding Citrate Dehydratase Activity 3 Iron, 4 Sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding	RNA Binding Double-stranded RNA Binding Structural Molecule Activity Protein Binding Protein Kinase Binding Clathrin Light Chain Binding Low-density Lipoprotein Particle Receptor Binding Disordered Domain Specific Binding Ubiquitin-specific Protease Binding
	Biological Process	Tricarboxylic Acid Cycle Citrate Metabolic Process Regulation Of Translation Cellular Iron Ion Homeostasis Post-embryonic Development Response To Iron(II) Ion Intestinal Absorption	Mitotic Cell Cycle Osteoblast Differentiation Intracellular Protein Transport Receptor-mediated Endocytosis Autophagy Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Receptor Internalization Low-density Lipoprotein Particle Receptor Catabolic Process Transferrin Transport Low-density Lipoprotein Particle Clearance Retrograde Transport, Endosome To Golgi Clathrin Coat Assembly Cell Division Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Mitotic Spindle Organization Membrane Organization Clathrin-dependent Endocytosis Amyloid-beta Clearance By Transcytosis Negative Regulation Of Hyaluronan Biosynthetic Process Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		Iron uptake and transport	Entry of Influenza Virion into Host Cell via Endocytosis Retrograde neurotrophin signalling Retrograde neurotrophin signalling Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Lysosome Vesicle Biogenesis Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance
Drugs
Diseases
GWAS		Asthma ( 22561531) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Immune response to measles-mumps-rubella vaccine ( 24811271) Inflammatory skin disease ( 25574825) Lateral ventricle temporal horn volume ( 31530798) Motion sickness ( 25628336) Red blood cell count ( 32888494 27863252) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		7 interacting genes: APP CCDC69 CDC42 CLTC MYBPC1 NEB PXN	61 interacting genes: ACO1 AFTPH AMPH AP1B1 AP1G1 AP3B1 AP3B2 ARMCX3 ARR3 ARRB1 ARRB2 C10orf88 CLINT1 CLTA CLTB DNAJC6 DUX4 EPN1 EPN2 ERG FYN GAK GGA1 GGA2 GGA3 GRIN1 GRIN2D HGS HIP1 HIP1R ITSN1 KIT LDLRAP1 MAP3K10 NCALD NDRG1 OCRL OPTN PICALM PPP1CA PPP1CC PRKACA PXN QARS1 SCYL2 SMAP1 SNX5 SNX9 SRC STAMBP SUMO2 SYNJ1 TFAP2A TNK2 TOM1 VCL WNK1 XRCC6 YWHAG YWHAQ ZFYVE9
Entrez ID		48	1213
HPRD ID		00013	00350
Ensembl ID		ENSG00000122729	ENSG00000141367
Uniprot IDs		P21399 Q9HBB2 V9HWB7	A0A087WVQ6 Q00610
PDB IDs		2B3X 2B3Y	2XZG 4G55 6E4L 6QNN 6QNP
Enriched GO Terms of Interacting Partners?
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