ACO1 and PXN

Data Source:
BioGRID (two hybrid)

		ACO1	PXN
Description		aconitase 1	paxillin
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Cytosol Extracellular Exosome	Stress Fiber Cytosol Microtubule Associated Complex Plasma Membrane Cell-cell Junction Focal Adhesion Cell Cortex Lamellipodium
	Molecular Function	RNA Binding Aconitate Hydratase Activity Protein Binding Iron-responsive Element Binding Metal Ion Binding Citrate Dehydratase Activity 3 Iron, 4 Sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding	Transcription Coregulator Activity Protein Binding Beta-catenin Binding Vinculin Binding Protein Phosphatase Binding Neuropilin Binding Metal Ion Binding
	Biological Process	Tricarboxylic Acid Cycle Citrate Metabolic Process Regulation Of Translation Cellular Iron Ion Homeostasis Post-embryonic Development Response To Iron(II) Ion Intestinal Absorption	Regulation Of Transcription, DNA-templated Muscle Contraction Cell Adhesion Cell-matrix Adhesion Signal Transduction Signal Complex Assembly Transforming Growth Factor Beta Receptor Signaling Pathway Substrate Adhesion-dependent Cell Spreading Cellular Response To Reactive Oxygen Species Endothelial Cell Migration Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly Growth Hormone Receptor Signaling Pathway
Pathways		Iron uptake and transport	GAB1 signalosome VEGFA-VEGFR2 Pathway Smooth Muscle Contraction Localization of the PINCH-ILK-PARVIN complex to focal adhesions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Drugs
Diseases
GWAS		Asthma ( 22561531) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Immune response to measles-mumps-rubella vaccine ( 24811271) Inflammatory skin disease ( 25574825) Lateral ventricle temporal horn volume ( 31530798) Motion sickness ( 25628336) Red blood cell count ( 32888494 27863252) Smoking status (ever vs never smokers) ( 30643258)	Bipolar disorder ( 31043756) Mean spheric corpuscular volume ( 32888494) Platelet count ( 29403010)
Interacting Genes		7 interacting genes: APP CCDC69 CDC42 CLTC MYBPC1 NEB PXN	87 interacting genes: ABL1 ACO1 AHCY AR ARHGEF7 ASAP1 ASAP2 BCAR1 BCL2 BLK CASP3 CEACAM1 CLTC CREB3L2 CRK CRKL CSK DGUOK DPY30 EPHB1 FYN GART GIT1 GIT2 GRB2 GSK3A GSK3B GSN HDAC6 ILK ITGA4 ITGA6 ITGA9 ITGAV ITGB1 ITGB3 LCK LIMK1 LMO1 LMO3 MAPK1 MAPK3 MAPK8 MATK NCK1 NEDD9 NF2 PABPC1 PAK1 PAK3 PARVA PDPK1 PKD1 PLEKHH2 PLEKHN1 POLR1D PPP2CA PPP2R5C PTEN PTK2 PTK2B PTPN11 PTPN12 PTPRH RASA1 REPS2 RHOU RNF5 SDC4 SELE SH3RF1 SORBS1 SRC SYK TCEANC TGM2 TLN1 TRIM15 TRIP6 TUBA1B TUBA3C TUBA8 TUBG1 TUBG2 VCL WHRN YES1
Entrez ID		48	5829
HPRD ID		00013	03937
Ensembl ID		ENSG00000122729	ENSG00000089159
Uniprot IDs		P21399 Q9HBB2 V9HWB7	A0A140VJQ8 P49023
PDB IDs		2B3X 2B3Y	1KKY 1KL0 1OW6 1OW7 1OW8 2K2R 2O9V 2VZD 2VZG 2VZI 3GM1 3PY7 3RQE 3RQF 3RQG 3U3F 4EDN 4R32 4XGZ 4XH2 5UWH 6IUI 6PW8 6U4M 6U4N
Enriched GO Terms of Interacting Partners?
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