UBE2E3 and RNF126

Data Source:
BioGRID (two hybrid)

		UBE2E3	RNF126
Description		ubiquitin conjugating enzyme E2 E3	ring finger protein 126
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity	Epidermal Growth Factor Receptor Binding Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Protein Ubiquitination Regulation Of Growth Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination	Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Population Proliferation Retrograde Transport, Endosome To Golgi Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 23749187) Basophil count ( 32888494) Body mass index ( 25673413) Celiac disease ( 22057235 20190752) Celiac disease and Rheumatoid arthritis ( 26546613) Heel bone mineral density ( 30598549) Lymphocyte counts ( 29403010) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Number of sexual partners ( 30643258) Obesity ( 21552555) QT interval ( 29213071) Red blood cell count ( 32888494 27863252) Risk-taking tendency (4-domain principal component model) ( 30643258) Sweet taste preference ( 32572145) White blood cell count ( 27863252)	Arterial stiffness ( 31070453) Arterial stiffness index ( 31235810) Pulse pressure ( 30578418)
Interacting Genes		95 interacting genes: ACVR1 ARID3A ARIH2 ARRDC3 ASXL2 ATXN1 BARD1 BRCA1 CADPS2 CBL CHFR CHUK CNOT4 CUL1 CUL3 CUL4A DAZAP2 DTX3 DTX3L DZIP3 H3C1 H4C1 HERC4 HTT IPO11 ITCH KLHL42 MARCHF5 MDM2 MID1 MID2 MKRN3 MUL1 NEDD4L NFKBIA OTUB1 PGPEP1 PICK1 PJA1 PRKN RANGAP1 RBX1 RC3H2 RCBTB1 RFWD3 RING1 RMND5B RNF11 RNF111 RNF114 RNF115 RNF126 RNF13 RNF130 RNF14 RNF150 RNF165 RNF166 RNF167 RNF181 RNF185 RNF2 RNF25 RNF31 RNF4 RNF43 RNF5 RNF8 SAE1 SIAH1 SPOP STUB1 TGFBR1 TRIM2 TRIM27 TRIM32 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 TRIM54 TRIM55 TRIM62 TRIM63 TTC3 UBA1 UBC UBOX5 UFM1 WBP2 WWP2 ZNF746 ZNRF1 ZNRF4	39 interacting genes: AICDA BAG6 CDKN1A CENPP CSNK2B E2F1 EGFR FXN HMGCL MAP3K1 MDM2 MIEN1 NUDT3 OTUB1 OTUB2 PLK1 PSMF1 RBX1 RNF168 SNUPN TRIM11 TRIM23 TRIM26 TRIM52 TSG101 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2E3 UBE2N UBL3 UBL4A USP15 USP2 XRCC5 XRCC6
Entrez ID		10477	55658
HPRD ID		05000	11501
Ensembl ID		ENSG00000170035	ENSG00000070423
Uniprot IDs		Q969T4 R4GNG6	A0A024R206 A8K0Q1 Q9BV68
PDB IDs			2N9O 2N9P
Enriched GO Terms of Interacting Partners?
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