UBE2E3 and WWP2

Data Source:
BioGRID (two hybrid, pull down)

		UBE2E3	WWP2
Description		ubiquitin conjugating enzyme E2 E3	WW domain containing E3 ubiquitin protein ligase 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Membrane Extracellular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity	RNA Polymerase II Transcription Factor Binding Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Protein Ubiquitination Regulation Of Growth Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Cellular Protein Modification Process Extracellular Transport Negative Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Transporter Activity Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Catabolic Process Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell Negative Regulation Of Protein Transport Protein Autoubiquitination Protein K63-linked Ubiquitination Regulation Of Potassium Ion Transmembrane Transporter Activity
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Regulation of PTEN stability and activity NOTCH3 Activation and Transmission of Signal to the Nucleus
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 23749187) Basophil count ( 32888494) Body mass index ( 25673413) Celiac disease ( 22057235 20190752) Celiac disease and Rheumatoid arthritis ( 26546613) Heel bone mineral density ( 30598549) Lymphocyte counts ( 29403010) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Number of sexual partners ( 30643258) Obesity ( 21552555) QT interval ( 29213071) Red blood cell count ( 32888494 27863252) Risk-taking tendency (4-domain principal component model) ( 30643258) Sweet taste preference ( 32572145) White blood cell count ( 27863252)	Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Cataracts (operation) ( 31816047) Diastolic blood pressure ( 30578418) Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31152163) FEV1 ( 30804560) Hand grip strength ( 29691431) Height ( 28552196 31562340) IgE levels ( 23146381) Knee osteoarthritis ( 30374069) Low density lipoprotein cholesterol levels ( 32154731) Lung function (FVC) ( 30804560) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Menarche (age at onset) ( 25231870) Plantar fascial disorders ( 29534260) Platelet count ( 32888494) Pulse pressure ( 30578418) Smoking behaviour (cigarette pack-years) ( 30679032) Triglyceride levels ( 31928498) Triglycerides ( 30275531) Waist circumference ( 31928498)
Interacting Genes		95 interacting genes: ACVR1 ARID3A ARIH2 ARRDC3 ASXL2 ATXN1 BARD1 BRCA1 CADPS2 CBL CHFR CHUK CNOT4 CUL1 CUL3 CUL4A DAZAP2 DTX3 DTX3L DZIP3 H3C1 H4C1 HERC4 HTT IPO11 ITCH KLHL42 MARCHF5 MDM2 MID1 MID2 MKRN3 MUL1 NEDD4L NFKBIA OTUB1 PGPEP1 PICK1 PJA1 PRKN RANGAP1 RBX1 RC3H2 RCBTB1 RFWD3 RING1 RMND5B RNF11 RNF111 RNF114 RNF115 RNF126 RNF13 RNF130 RNF14 RNF150 RNF165 RNF166 RNF167 RNF181 RNF185 RNF2 RNF25 RNF31 RNF4 RNF43 RNF5 RNF8 SAE1 SIAH1 SPOP STUB1 TGFBR1 TRIM2 TRIM27 TRIM32 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 TRIM54 TRIM55 TRIM62 TRIM63 TTC3 UBA1 UBC UBOX5 UFM1 WBP2 WWP2 ZNF746 ZNRF1 ZNRF4	79 interacting genes: ANKRD44 ARRDC1 ARRDC3 ATN1 CDC34 CLCN5 CPSF6 DAG1 DIDO1 EFCAB3 EGR2 EWSR1 FAM189A2 FAM214B FBXL18 GADD45GIP1 GAS2L2 GGN GRAP2 HNRNPUL1 IFIT2 IL2RG IL6R LGALS9B MED25 MIR19A MIR19B1 MIR92A1 NDFIP1 NDFIP2 PAIP1 PATZ1 PDLIM7 PRKAA2 PSMF1 RASA1 RASD1 RNF11 RUSC1 SCAMP3 SCN5A SCNN1A SCNN1B SCNN1G SEC24D SF1 SFTPC SLC9A3R2 SMAD3 SMAD7 SMARCD1 SMR3A SNRPB SNRPC SPART TFAP2A TNK2 TP53BP2 TRAF4 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2I UBE2J2 UBE2K UBE2L3 UBTD1 USP7 VASP VPS37C WBP1 WBP2 WDR5 WIPF1 ZNF688
Entrez ID		10477	11060
HPRD ID		05000	03812
Ensembl ID		ENSG00000170035	ENSG00000198373
Uniprot IDs		Q969T4 R4GNG6	A0A024R711 B4DHF6 O00308
PDB IDs			4Y07 5TJ7 5TJ8 5TJQ 6J1Z 6RSS
Enriched GO Terms of Interacting Partners?
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