UBE2E3 and DTX3L

Data Source:
BioGRID (two hybrid)

		UBE2E3	DTX3L
Description		ubiquitin conjugating enzyme E2 E3	deltex E3 ubiquitin ligase 3L
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Early Endosome Cytosol Early Endosome Membrane Protein-containing Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity	Ubiquitin-protein Transferase Activity Enzyme Inhibitor Activity Protein Binding Enzyme Activator Activity Enzyme Binding Histone Binding Ubiquitin-like Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity STAT Family Protein Binding
	Biological Process	Protein Polyubiquitination Protein Ubiquitination Regulation Of Growth Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination	Protein Polyubiquitination Positive Regulation Of Defense Response To Virus By Host Double-strand Break Repair Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Notch Signaling Pathway Endosome To Lysosome Transport Histone Monoubiquitination Protein Transport Viral Process Protein Ubiquitination Positive Regulation Of Protein Binding Histone H2A Ubiquitination Histone H2B Ubiquitination Positive Regulation Of Chromatin Binding Innate Immune Response Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Ubiquitin-protein Transferase Activity Defense Response To Virus Protein Autoubiquitination Protein K48-linked Ubiquitination Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of NAD+ ADP-ribosyltransferase Activity Positive Regulation Of Protein Localization To Early Endosome Positive Regulation Of Receptor Catabolic Process Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 23749187) Basophil count ( 32888494) Body mass index ( 25673413) Celiac disease ( 22057235 20190752) Celiac disease and Rheumatoid arthritis ( 26546613) Heel bone mineral density ( 30598549) Lymphocyte counts ( 29403010) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Number of sexual partners ( 30643258) Obesity ( 21552555) QT interval ( 29213071) Red blood cell count ( 32888494 27863252) Risk-taking tendency (4-domain principal component model) ( 30643258) Sweet taste preference ( 32572145) White blood cell count ( 27863252)	Low density lipoprotein cholesterol levels ( 32154731) Major depressive disorder ( 22472876)
Interacting Genes		95 interacting genes: ACVR1 ARID3A ARIH2 ARRDC3 ASXL2 ATXN1 BARD1 BRCA1 CADPS2 CBL CHFR CHUK CNOT4 CUL1 CUL3 CUL4A DAZAP2 DTX3 DTX3L DZIP3 H3C1 H4C1 HERC4 HTT IPO11 ITCH KLHL42 MARCHF5 MDM2 MID1 MID2 MKRN3 MUL1 NEDD4L NFKBIA OTUB1 PGPEP1 PICK1 PJA1 PRKN RANGAP1 RBX1 RC3H2 RCBTB1 RFWD3 RING1 RMND5B RNF11 RNF111 RNF114 RNF115 RNF126 RNF13 RNF130 RNF14 RNF150 RNF165 RNF166 RNF167 RNF181 RNF185 RNF2 RNF25 RNF31 RNF4 RNF43 RNF5 RNF8 SAE1 SIAH1 SPOP STUB1 TGFBR1 TRIM2 TRIM27 TRIM32 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 TRIM54 TRIM55 TRIM62 TRIM63 TTC3 UBA1 UBC UBOX5 UFM1 WBP2 WWP2 ZNF746 ZNRF1 ZNRF4	20 interacting genes: DTX1 H2AZ2 ITCH PARP9 PHF7 RNF111 SPG21 TRIM9 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2R2 UBE2W
Entrez ID		10477	151636
HPRD ID		05000	16843
Ensembl ID		ENSG00000170035	ENSG00000163840
Uniprot IDs		Q969T4 R4GNG6	Q8TDB6
PDB IDs			3PG6
Enriched GO Terms of Interacting Partners?
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