Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
TRAF6 and PINK1
Data Source:
BioGRID
(affinity chromatography technology, enzymatic study)
TRAF6
PINK1
Description
TNF receptor associated factor 6
PTEN induced kinase 1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Lipid Droplet
Cytosol
Plasma Membrane
Cell Cortex
Cytoplasmic Side Of Plasma Membrane
Endosome Membrane
Protein-containing Complex
CD40 Receptor Complex
Perinuclear Region Of Cytoplasm
Plasma Membrane Signaling Receptor Complex
Chromatin
Nucleus
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Mitochondrial Inner Membrane
Mitochondrial Intermembrane Space
Endoplasmic Reticulum
Cytosol
Cytoskeleton
Membrane
Axon
Growth Cone
Integral Component Of Mitochondrial Outer Membrane
Cell Body
Perinuclear Region Of Cytoplasm
Lewy Body
Astrocyte Projection
Molecular Function
Ubiquitin-protein Transferase Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Zinc Ion Binding
Protein Kinase Binding
Mitogen-activated Protein Kinase Kinase Kinase Binding
Ubiquitin Conjugating Enzyme Binding
Ubiquitin Protein Ligase Binding
Thioesterase Binding
Identical Protein Binding
Histone Deacetylase Binding
Protein Kinase B Binding
Protein N-terminus Binding
Ubiquitin Protein Ligase Activity
Magnesium Ion Binding
Protease Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Calcium-dependent Protein Kinase Activity
Kinase Activity
Peptidase Activator Activity
Ubiquitin Protein Ligase Binding
Protein Kinase B Binding
Protein-containing Complex Binding
C3HC4-type RING Finger Domain Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
TORC2 Complex Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Activation Of MAPK Activity
Protein Polyubiquitination
Ossification
In Utero Embryonic Development
Neural Tube Closure
Stimulatory C-type Lectin Receptor Signaling Pathway
Toll-like Receptor Signaling Pathway
Regulation Of Immunoglobulin Production
Positive Regulation Of T Cell Cytokine Production
MyD88-dependent Toll-like Receptor Signaling Pathway
Cellular Response To DNA Damage Stimulus
I-kappaB Kinase/NF-kappaB Signaling
Activation Of NF-kappaB-inducing Kinase Activity
JNK Cascade
Protein Deubiquitination
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Osteoclast Differentiation
Membrane Protein Intracellular Domain Proteolysis
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway
Activation Of Protein Kinase Activity
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Interleukin-6 Production
Tumor Necrosis Factor-mediated Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
T-helper 1 Type Immune Response
Positive Regulation Of T Cell Proliferation
Odontogenesis Of Dentin-containing Tooth
Myeloid Dendritic Cell Differentiation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of JUN Kinase Activity
Bone Resorption
Positive Regulation Of Osteoclast Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of JNK Cascade
Cell Development
Positive Regulation Of Smooth Muscle Cell Proliferation
T Cell Receptor Signaling Pathway
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein Autoubiquitination
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Protein K63-linked Ubiquitination
Response To Interleukin-1
Cellular Response To Lipopolysaccharide
Cellular Response To Cytokine Stimulus
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Positive Regulation Of Transcription Regulatory Region DNA Binding
Autophagy Of Mitochondrion
Positive Regulation Of Protein Phosphorylation
Regulation Of Oxidative Phosphorylation
Response To Ischemia
Protein Phosphorylation
Ubiquitin-dependent Protein Catabolic Process
Response To Oxidative Stress
Mitochondrion Organization
Regulation Of Hydrogen Peroxide Metabolic Process
Negative Regulation Of Gene Expression
Regulation Of Mitochondrion Organization
Positive Regulation Of Peptidase Activity
Macroautophagy
Positive Regulation Of Macroautophagy
Negative Regulation Of Macroautophagy
Protein Ubiquitination
Peptidyl-serine Phosphorylation
Respiratory Electron Transport Chain
Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Activation Of Protein Kinase B Activity
Positive Regulation Of Synaptic Transmission, Dopaminergic
Positive Regulation Of Peptidyl-serine Phosphorylation
Positive Regulation Of Dopamine Secretion
Cellular Response To Oxidative Stress
Positive Regulation Of Protein Dephosphorylation
Intracellular Signal Transduction
Peptidyl-serine Autophosphorylation
TORC2 Signaling
Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Protein-containing Complex Assembly
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Translation
Negative Regulation Of JNK Cascade
Protein Stabilization
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Mitochondrial Membrane Potential
Positive Regulation Of Protein Kinase B Signaling
Regulation Of Proteasomal Protein Catabolic Process
Cellular Response To Hypoxia
Establishment Of Protein Localization To Mitochondrion
Maintenance Of Protein Location In Mitochondrion
Positive Regulation Of Mitochondrial Fission
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Negative Regulation Of Mitochondrial Fission
Cellular Response To Toxic Substance
Positive Regulation Of Mitophagy In Response To Mitochondrial Depolarization
Mitochondrion To Lysosome Transport
Regulation Of Cellular Response To Oxidative Stress
Positive Regulation Of Histone Deacetylase Activity
Regulation Of Synaptic Vesicle Transport
Negative Regulation Of Autophagosome Assembly
Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone
Regulation Of Autophagy Of Mitochondrion
Negative Regulation Of Autophagy Of Mitochondrion
Negative Regulation Of Oxidative Stress-induced Cell Death
Negative Regulation Of Oxidative Stress-induced Neuron Death
Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide
Positive Regulation Of Cristae Formation
Positive Regulation Of Protein Targeting To Mitochondrion
Positive Regulation Of Free Ubiquitin Chain Polymerization
Positive Regulation Of NMDA Glutamate Receptor Activity
Cellular Response To Hydrogen Sulfide
Regulation Of Reactive Oxygen Species Metabolic Process
Negative Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of ATP Biosynthetic Process
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
PIP3 activates AKT signaling
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
Regulated proteolysis of p75NTR
Downstream TCR signaling
NRIF signals cell death from the nucleus
NRIF signals cell death from the nucleus
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
FCERI mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
CLEC7A (Dectin-1) signaling
Ub-specific processing proteases
Ovarian tumor domain proteases
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
TICAM1,TRAF6-dependent induction of TAK1 complex
Interleukin-1 signaling
TRAF6 mediated IRF7 activation
TRAF6 mediated NF-kB activation
TRAF6 mediated NF-kB activation
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
IRAK2 mediated activation of TAK1 complex
TRAF6-mediated induction of TAK1 complex within TLR4 complex
Alpha-protein kinase 1 signaling pathway
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
MyD88 dependent cascade initiated on endosome
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
MyD88 cascade initiated on plasma membrane
PINK1-PRKN Mediated Mitophagy
FOXO-mediated transcription of cell death genes
Drugs
Diseases
Parkinson's disease (PD)
GWAS
Idiopathic inflammatory myopathy (
26362759
)
Metabolite levels (
23823483
)
Rheumatoid arthritis (
30423114
24390342
)
Household income (MTAG) (
31844048
)
Itch intensity from mosquito bite adjusted by bite size (
28199695
)
Paclitaxel disposition in epithelial ovarian cancer (
29367611
)
Proportion of activated microglia (inferior temporal cortex) (
30679421
)
Interacting Genes
174 interacting genes:
ABL1
APP
ATM
ATP6V1E1
ATXN3
BANK1
BCL3
BEX3
BMPR1B
BRSK2
CALCOCO2
CASP8
CAV1
CBL
CD40
CUL5
CYLD
DLG4
DNA2
ECSIT
EDA2R
EDARADD
FHL2
FYN
GART
GSK3B
GTF2I
H2AX
H2BC21
HNRNPA1
HSD17B10
HSPA4
IL17RB
IPMK
IQUB
IRAK1
IRAK2
IRAK3
IRAK4
IRF5
IRF7
IRF8
JAK2
KCNQ1
LIMD1
LNX1
MALT1
MAP2K1
MAP2K6
MAP2K7
MAP3K11
MAP3K14
MAP3K3
MAP3K5
MAP3K7
MAP3K8
MAPK14
MAPK8
MAPT
MAST2
MATR3
MAVS
MBP
MCL1
MEOX2
MTOR
MTURN
NEAT1
NGFR
NTRK1
NTRK2
NUMBL
OTUB1
OTUB2
OTUD7B
PEDS1-UBE2V1
PELI3
PFN1
PINK1
PLEKHF2
PLEKHO1
POLI
PPP4C
PRKCZ
PSMB5
PSMC1
PSMC2
PSMC3
PSMD1
PSMD12
PSMD13
PSMD6
PSMD7
PTPN6
RAD23A
RIPK2
RNF114
RNF31
RPL3
RPS2
RPS20
RPS27A
SIGIRR
SPHK1
SPOP
SQSTM1
SRC
STAMBP
STK26
STRADB
STUB1
SYK
TAB1
TAB2
TAB3
TANK
TAX1BP1
TDP2
TGFBR1
TICAM1
TICAM2
TIFA
TIRAP
TLR3
TNFAIP3
TNFRSF11A
TNFRSF13B
TNFRSF19
TNFSF11
TRAF1
TRAF2
TRAF3IP1
TRAF3IP2
TRAF4
TRAF5
TRAF7
TRAFD1
TRAM1
TRIM17
TRIM25
TRIM37
TXNIP
UBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2I
UBE2L3
UBE2N
UBE2V1
UBOX5
UBTD1
UBXN7
UEVLD
USP1
USP15
USP2
USP21
USP39
USP7
VPS52
XIAP
YBX1
YES1
YOD1
YWHAQ
ZBTB25
ZFAND5
ZMYND11
ZNF675
ZRANB1
16 interacting genes:
APPL2
BAG2
BAG5
CRLS1
DNM1L
FBXO7
HSH2D
MAP3K7
MARK2
NEAT1
PARK7
SNCAIP
STAT3
TGM2
TRAF6
UBE2M
Entrez ID
7189
65018
HPRD ID
03833
10514
Ensembl ID
ENSG00000175104
ENSG00000158828
Uniprot IDs
Q9Y4K3
Q9BXM7
PDB IDs
1LB4
1LB5
1LB6
2ECI
2JMD
3HCS
3HCT
3HCU
4Z8M
5ZUJ
6A33
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?