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TRAF6 and VPS52
Data Source:
BioGRID
(two hybrid)
TRAF6
VPS52
Description
TNF receptor associated factor 6
VPS52 subunit of GARP complex
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Lipid Droplet
Cytosol
Plasma Membrane
Cell Cortex
Cytoplasmic Side Of Plasma Membrane
Endosome Membrane
Protein-containing Complex
CD40 Receptor Complex
Perinuclear Region Of Cytoplasm
Plasma Membrane Signaling Receptor Complex
GARP Complex
Golgi Apparatus
Cytosol
Endosome Membrane
Membrane
Trans-Golgi Network Membrane
Perinuclear Region Of Cytoplasm
Recycling Endosome
EARP Complex
Molecular Function
Ubiquitin-protein Transferase Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Zinc Ion Binding
Protein Kinase Binding
Mitogen-activated Protein Kinase Kinase Kinase Binding
Ubiquitin Conjugating Enzyme Binding
Ubiquitin Protein Ligase Binding
Thioesterase Binding
Identical Protein Binding
Histone Deacetylase Binding
Protein Kinase B Binding
Protein N-terminus Binding
Ubiquitin Protein Ligase Activity
Protein Binding
Syntaxin Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Activation Of MAPK Activity
Protein Polyubiquitination
Ossification
In Utero Embryonic Development
Neural Tube Closure
Stimulatory C-type Lectin Receptor Signaling Pathway
Toll-like Receptor Signaling Pathway
Regulation Of Immunoglobulin Production
Positive Regulation Of T Cell Cytokine Production
MyD88-dependent Toll-like Receptor Signaling Pathway
Cellular Response To DNA Damage Stimulus
I-kappaB Kinase/NF-kappaB Signaling
Activation Of NF-kappaB-inducing Kinase Activity
JNK Cascade
Protein Deubiquitination
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Osteoclast Differentiation
Membrane Protein Intracellular Domain Proteolysis
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway
Activation Of Protein Kinase Activity
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Interleukin-6 Production
Tumor Necrosis Factor-mediated Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
T-helper 1 Type Immune Response
Positive Regulation Of T Cell Proliferation
Odontogenesis Of Dentin-containing Tooth
Myeloid Dendritic Cell Differentiation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of JUN Kinase Activity
Bone Resorption
Positive Regulation Of Osteoclast Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of JNK Cascade
Cell Development
Positive Regulation Of Smooth Muscle Cell Proliferation
T Cell Receptor Signaling Pathway
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein Autoubiquitination
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Protein K63-linked Ubiquitination
Response To Interleukin-1
Cellular Response To Lipopolysaccharide
Cellular Response To Cytokine Stimulus
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Positive Regulation Of Transcription Regulatory Region DNA Binding
Golgi To Vacuole Transport
Lysosomal Transport
Ectodermal Cell Differentiation
Protein Transport
Endocytic Recycling
Retrograde Transport, Endosome To Golgi
Embryonic Ectodermal Digestive Tract Development
Pathways
PIP3 activates AKT signaling
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
Regulated proteolysis of p75NTR
Downstream TCR signaling
NRIF signals cell death from the nucleus
NRIF signals cell death from the nucleus
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
FCERI mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
CLEC7A (Dectin-1) signaling
Ub-specific processing proteases
Ovarian tumor domain proteases
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
TICAM1,TRAF6-dependent induction of TAK1 complex
Interleukin-1 signaling
TRAF6 mediated IRF7 activation
TRAF6 mediated NF-kB activation
TRAF6 mediated NF-kB activation
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
IRAK2 mediated activation of TAK1 complex
TRAF6-mediated induction of TAK1 complex within TLR4 complex
Alpha-protein kinase 1 signaling pathway
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
MyD88 dependent cascade initiated on endosome
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
MyD88 cascade initiated on plasma membrane
Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases
GWAS
Idiopathic inflammatory myopathy (
26362759
)
Metabolite levels (
23823483
)
Rheumatoid arthritis (
30423114
24390342
)
Autism spectrum disorder or schizophrenia (
28540026
)
Body mass index (
26426971
)
Interacting Genes
174 interacting genes:
ABL1
APP
ATM
ATP6V1E1
ATXN3
BANK1
BCL3
BEX3
BMPR1B
BRSK2
CALCOCO2
CASP8
CAV1
CBL
CD40
CUL5
CYLD
DLG4
DNA2
ECSIT
EDA2R
EDARADD
FHL2
FYN
GART
GSK3B
GTF2I
H2AX
H2BC21
HNRNPA1
HSD17B10
HSPA4
IL17RB
IPMK
IQUB
IRAK1
IRAK2
IRAK3
IRAK4
IRF5
IRF7
IRF8
JAK2
KCNQ1
LIMD1
LNX1
MALT1
MAP2K1
MAP2K6
MAP2K7
MAP3K11
MAP3K14
MAP3K3
MAP3K5
MAP3K7
MAP3K8
MAPK14
MAPK8
MAPT
MAST2
MATR3
MAVS
MBP
MCL1
MEOX2
MTOR
MTURN
NEAT1
NGFR
NTRK1
NTRK2
NUMBL
OTUB1
OTUB2
OTUD7B
PEDS1-UBE2V1
PELI3
PFN1
PINK1
PLEKHF2
PLEKHO1
POLI
PPP4C
PRKCZ
PSMB5
PSMC1
PSMC2
PSMC3
PSMD1
PSMD12
PSMD13
PSMD6
PSMD7
PTPN6
RAD23A
RIPK2
RNF114
RNF31
RPL3
RPS2
RPS20
RPS27A
SIGIRR
SPHK1
SPOP
SQSTM1
SRC
STAMBP
STK26
STRADB
STUB1
SYK
TAB1
TAB2
TAB3
TANK
TAX1BP1
TDP2
TGFBR1
TICAM1
TICAM2
TIFA
TIRAP
TLR3
TNFAIP3
TNFRSF11A
TNFRSF13B
TNFRSF19
TNFSF11
TRAF1
TRAF2
TRAF3IP1
TRAF3IP2
TRAF4
TRAF5
TRAF7
TRAFD1
TRAM1
TRIM17
TRIM25
TRIM37
TXNIP
UBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2I
UBE2L3
UBE2N
UBE2V1
UBOX5
UBTD1
UBXN7
UEVLD
USP1
USP15
USP2
USP21
USP39
USP7
VPS52
XIAP
YBX1
YES1
YOD1
YWHAQ
ZBTB25
ZFAND5
ZMYND11
ZNF675
ZRANB1
104 interacting genes:
AAMP
ARNT2
ATP6V1D
BORCS6
BYSL
C1orf109
C1orf216
C2CD6
CABP5
CACNA1A
CCDC102B
CCDC13
CCDC146
CCDC185
CCDC187
CCDC33
CCDC57
CCHCR1
CDC20B
CDC5L
CDK18
CEP19
CFAP206
CWF19L2
DCX
DDX6
DNAJC11
DTNB
EEF1AKNMT
EPM2AIP1
FAM110A
FAM161A
FAM161B
FAM184A
FAM50B
GEM
GFM2
GOLGA1
GORASP2
GPKOW
HAUS1
HDAC4
HEATR1
HGS
HOXB5
JAKMIP2
KANK2
KIAA1217
KIF5B
KIF9
KIFC3
KLC3
KLHL42
LMO4
LNX1
MAGEL2
MAPK3
MFAP1
MRPL1
MRPL11
NDC80
NFKBIB
NOP2
NR2C2AP
OTUD6A
PIMREG
PKN3
PPP1R18
PRKAA1
PRKAA2
RAB4A
RAB4B
RABEP2
RNF41
RUNX1T1
SCNM1
SH2D4A
SMARCE1
STX11
TAB2
TBC1D1
TBC1D22B
TCEANC
TCP11L1
TEAD4
THAP11
TPM3
TRAF4
TRAF6
TSSK3
TSTD2
TXLNA
TXLNB
TXN2
USP2
VEZF1
VPS28
VPS53
WASHC3
WTAP
ZC2HC1C
ZMAT2
ZNF417
ZNF587
Entrez ID
7189
6293
HPRD ID
03833
09142
Ensembl ID
ENSG00000175104
ENSG00000223501
Uniprot IDs
Q9Y4K3
A0A1U9X8S4
B3KMF7
B4DS44
Q4VXZ2
Q8N1B4
PDB IDs
1LB4
1LB5
1LB6
2ECI
2JMD
3HCS
3HCT
3HCU
4Z8M
5ZUJ
6A33
Enriched GO Terms of Interacting Partners
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