NDUFAB1 and BBC3

Data Source:
BioGRID (two hybrid)

		NDUFAB1	BBC3
Description		NADH:ubiquinone oxidoreductase subunit AB1	BCL2 binding component 3
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex I Mitochondrial Matrix Mitochondrial Large Ribosomal Subunit Mitochondrial Membrane	Mitochondrion Lysosome
	Molecular Function	Acyl Binding Acyl Carrier Activity Fatty Acid Binding Calcium Ion Binding Protein Binding NADH Dehydrogenase (ubiquinone) Activity	Protein Binding ATPase Binding
	Biological Process	Mitochondrial Electron Transport, NADH To Ubiquinone Fatty Acid Biosynthetic Process Protein Lipoylation Mitochondrial Respiratory Chain Complex I Assembly	Release Of Cytochrome C From Mitochondria Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Release Of Cytochrome C From Mitochondria Execution Phase Of Apoptosis Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Glyoxylate metabolism and glycine degradation Respiratory electron transport Complex I biogenesis Mitochondrial Fatty Acid Beta-Oxidation	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release FOXO-mediated transcription of cell death genes
Drugs		NADH
Diseases
GWAS		Bipolar disorder ( 17554300)	Monocyte count ( 27863252) White blood cell count ( 32888494)
Interacting Genes		35 interacting genes: ACTN3 BBC3 BEX5 CCDC24 CNTF EIF3B ERBB3 FEM1A FHL3 FNDC3B HINFP KCTD9 LMO2 LNX1 MBLAC1 MORN3 MRPL23 NOXA1 NRF1 NT5C3A NTAQ1 OIP5 POP5 PPP1R16A PSMC3 RBM18 SLIRP SMYD3 THAP1 TLX3 TOX2 VAC14 ZNF19 ZNF410 ZNF829	14 interacting genes: BAX BCL2 BCL2A1 BCL2L1 BCL2L2 FHL5 HGS HSD17B13 MCL1 MYPOP NDUFAB1 UBASH3B WDR5 ZNF438
Entrez ID		4706	27113
HPRD ID		11951	16165
Ensembl ID		ENSG00000004779	ENSG00000105327
Uniprot IDs		O14561	Q96PG8 Q9BXH1
PDB IDs		2DNW 5OOL 5OOM 5XTB 5XTC 5XTD 5XTH 5XTI 6ODD	2M04 4BPI 4BPJ 4BPK 4HNJ 5UUL 6QFM 6QG8 6TQP
Enriched GO Terms of Interacting Partners?
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