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BBC3 and BCL2L1
Data Source:
HPRD
(in vitro, two hybrid)
BBC3
BCL2L1
Description
BCL2 binding component 3
BCL2 like 1
Image
GO Annotations
Cellular Component
Mitochondrion
Lysosome
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Mitochondrial Inner Membrane
Mitochondrial Matrix
Centrosome
Cytosol
Integral Component Of Membrane
Synaptic Vesicle Membrane
Nuclear Membrane
Bcl-2 Family Protein Complex
Molecular Function
Protein Binding
ATPase Binding
Protein Binding
Protein Kinase Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
BH3 Domain Binding
Biological Process
Release Of Cytochrome C From Mitochondria
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Execution Phase Of Apoptosis
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Release Of Cytochrome C From Mitochondria
Endocytosis
Mitotic Cell Cycle Checkpoint
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Apoptotic Mitochondrial Changes
Suppression By Virus Of Host Apoptotic Process
Cytokine-mediated Signaling Pathway
Regulation Of Cytokinesis
Response To Cytokine
Negative Regulation Of Apoptotic Process
Regulation Of Mitochondrial Membrane Permeability
Defense Response To Virus
Regulation Of Mitochondrial Membrane Potential
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Negative Regulation Of Execution Phase Of Apoptosis
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Protein Localization To Plasma Membrane
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Activation of PUMA and translocation to mitochondria
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
FOXO-mediated transcription of cell death genes
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Interleukin-4 and Interleukin-13 signaling
The NLRP1 inflammasome
RAS processing
STAT5 activation downstream of FLT3 ITD mutants
Drugs
4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID
Isosorbide
Gossypol
Diseases
GWAS
Monocyte count (
27863252
)
White blood cell count (
32888494
)
Brain morphology (MOSTest) (
32665545
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Monocyte percentage of white cells (
27863252
)
Mosaic loss of chromosome Y (Y chromosome dosage) (
31624269
)
Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder (
26184070
)
Platelet count (
32888494
27863252
)
Plateletcrit (
32888494
27863252
)
Prudent dietary pattern (
28644415
)
Putamen volume (
29147026
)
Subcortical brain region volumes (
25607358
)
Interacting Genes
14 interacting genes:
BAX
BCL2
BCL2A1
BCL2L1
BCL2L2
FHL5
HGS
HSD17B13
MCL1
MYPOP
NDUFAB1
UBASH3B
WDR5
ZNF438
110 interacting genes:
ACTB
AKT1
ANTXR1
APAF1
AURKA
AVEN
BAD
BAG1
BAK1
BAX
BBC3
BCAP31
BCL2
BCL2L10
BCL2L11
BCL2L12
BCL2L14
BCLAF1
BECN1
BID
BIK
BLK
BMF
BNIP1
BNIP3
BNIP3L
BNIP5
BNIPL
C10orf67
CAPN1
CASP1
CASP8
CASP9
CDKN2A
CFLAR
CHEK1
CREB3
CRYAA
CRYAB
CYCS
DOCK7
EDRF1
ELOVL4
ERGIC3
FBP1
FKBP8
G0S2
GLOD4
GNLY
GOLM1
GORAB
GSK3A
GSK3B
HNRNPA1
HRK
IKZF3
IRS1
IRS2
LARP1
MAPK14
MAPK8
MAPK9
MAPKAPK2
MCL1
METTL23
MOAP1
MTIF3
MTNR1B
MTOR
NLRP1
PARK7
PDIA4
PLD3
PLK1
PLK3
PMAIP1
PPHLN1
PPP1CA
PRKN
PSEN1
PSEN2
PTN
RAD9A
RAF1
RBM5
REEP4
RHBDD2
RIC3
RNF183
RNF4
RTN1
RTN4
RYR3
SIVA1
SNCA
SPNS1
TLE1
TMBIM6
TMEM50B
TP53
TP53BP2
TPT1
UBE2I
UBR1
UHRF2
VAC14
VDAC1
ZFYVE1
ZHX1
ZNF219
Entrez ID
27113
598
HPRD ID
16165
02497
Ensembl ID
ENSG00000105327
ENSG00000171552
Uniprot IDs
Q96PG8
Q9BXH1
A0A0S2Z3C5
Q07817
Q5TE63
PDB IDs
2M04
4BPI
4BPJ
4BPK
4HNJ
5UUL
6QFM
6QG8
6TQP
1BXL
1G5J
1LXL
1MAZ
1R2D
1R2E
1R2G
1R2H
1R2I
1YSG
1YSI
1YSN
2B48
2LP8
2LPC
2M03
2M04
2ME8
2ME9
2MEJ
2O1Y
2O2M
2O2N
2P1L
2PON
2YJ1
2YQ6
2YQ7
2YXJ
3CVA
3FDL
3FDM
3INQ
3IO8
3PL7
3QKD
3R85
3SP7
3SPF
3WIZ
3ZK6
3ZLN
3ZLO
3ZLR
4A1U
4A1W
4AQ3
4BPK
4C52
4C5D
4CIN
4EHR
4HNJ
4IEH
4PPI
4QVE
4QVF
4QVX
4TUH
4Z9V
5AGW
5AGX
5B1Z
5C3G
5FMJ
5FMK
5VAY
5VX3
6BF2
6DCN
6DCO
6F46
6HJL
6IJQ
6O0K
6O0L
6O0M
6O0O
6O0P
6RNU
6ST2
6VWC
6X7I
6ZHC
7CA4
Enriched GO Terms of Interacting Partners
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