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BBC3 and BAX
Data Source:
HPRD
(two hybrid)
BBC3
BAX
Description
BCL2 binding component 3
BCL2 associated X, apoptosis regulator
Image
GO Annotations
Cellular Component
Mitochondrion
Lysosome
Nucleus
Nuclear Envelope
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Mitochondrial Permeability Transition Pore Complex
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Membrane
Pore Complex
Extracellular Exosome
Cell Periphery
Bcl-2 Family Protein Complex
BAX Complex
BAK Complex
Molecular Function
Protein Binding
ATPase Binding
Protein Binding
Lipid Binding
Channel Activity
Hsp70 Protein Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Chaperone Binding
BH3 Domain Binding
Biological Process
Release Of Cytochrome C From Mitochondria
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Execution Phase Of Apoptosis
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Ovarian Follicle Development
Neuron Migration
T Cell Homeostatic Proliferation
B Cell Homeostasis
B Cell Apoptotic Process
Kidney Development
Release Of Cytochrome C From Mitochondria
Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Blood Vessel Remodeling
Myeloid Cell Homeostasis
B Cell Negative Selection
B Cell Homeostatic Proliferation
Positive Regulation Of B Cell Apoptotic Process
Transcription Initiation From RNA Polymerase II Promoter
Glycosphingolipid Metabolic Process
Regulation Of Nitrogen Utilization
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Germ Cell Development
Mitochondrial Fusion
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C
Apoptotic Mitochondrial Changes
Fertilization
Response To Toxic Substance
Response To Salt Stress
Establishment Or Maintenance Of Transmembrane Electrochemical Gradient
Response To Gamma Radiation
Negative Regulation Of Mitochondrial Membrane Potential
Viral Process
Hypothalamus Development
Cerebral Cortex Development
Positive Regulation Of Protein-containing Complex Assembly
Negative Regulation Of Protein Binding
Endoplasmic Reticulum Calcium Ion Homeostasis
Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration
Release Of Matrix Enzymes From Mitochondria
Negative Regulation Of Peptidyl-serine Phosphorylation
Regulation Of Mammary Gland Epithelial Cell Proliferation
Cellular Response To Unfolded Protein
Cellular Response To UV
Ectopic Germ Cell Programmed Cell Death
Odontogenesis Of Dentin-containing Tooth
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Neuron Apoptotic Process
Mitochondrial Fragmentation Involved In Apoptotic Process
Development Of Secondary Sexual Characteristics
Retinal Cell Programmed Cell Death
Positive Regulation Of Developmental Pigmentation
Negative Regulation Of Fibroblast Proliferation
Spermatid Differentiation
Post-embryonic Camera-type Eye Morphogenesis
Response To Axon Injury
Homeostasis Of Number Of Cells Within A Tissue
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Neuron Apoptotic Process
Regulation Of Mitochondrial Membrane Potential
Sertoli Cell Proliferation
Retina Development In Camera-type Eye
Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution
Vagina Development
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Thymocyte Apoptotic Process
Mitochondrion Morphogenesis
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Intrinsic Apoptotic Signaling Pathway
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Cellular Response To Virus
Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Apoptotic Process Involved In Blood Vessel Morphogenesis
Apoptotic Process Involved In Embryonic Digit Morphogenesis
Regulation Of Mitochondrial Membrane Permeability Involved In Programmed Necrotic Cell Death
Positive Regulation Of Apoptotic DNA Fragmentation
Positive Regulation Of IRE1-mediated Unfolded Protein Response
B Cell Receptor Apoptotic Signaling Pathway
Negative Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Activation of PUMA and translocation to mitochondria
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
FOXO-mediated transcription of cell death genes
Release of apoptotic factors from the mitochondria
Activation, translocation and oligomerization of BAX
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Transcriptional regulation by RUNX2
NTRK3 as a dependence receptor
Drugs
Diseases
Colorectal cancer
GWAS
Monocyte count (
27863252
)
White blood cell count (
32888494
)
Asthma (
27611488
)
Eosinophil counts (
32888494
27863252
)
Eosinophil percentage of white cells (
32888494
)
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
)
Neutrophil percentage of granulocytes (
27863252
)
Plateletcrit (
32888494
)
Sum eosinophil basophil counts (
27863252
)
White blood cell count (
32888494
)
Interacting Genes
14 interacting genes:
BAX
BCL2
BCL2A1
BCL2L1
BCL2L2
FHL5
HGS
HSD17B13
MCL1
MYPOP
NDUFAB1
UBASH3B
WDR5
ZNF438
30 interacting genes:
ANP32B
BAK1
BBC3
BCL2
BCL2A1
BCL2L1
BCL2L10
BCL2L12
BCL2L2
BID
ERN1
HSF2BP
KCNA3
LEF1
MAP2K1
MCL1
MOAP1
NOL3
PARK7
PMAIP1
PPP1CA
SFN
SH3GLB1
SLC25A4
TP53
UHRF2
VDAC1
YWHAB
YWHAQ
ZBTB24
Entrez ID
27113
581
HPRD ID
16165
02498
Ensembl ID
ENSG00000105327
ENSG00000087088
Uniprot IDs
Q96PG8
Q9BXH1
I6LPK7
Q07812
Q5ZPJ0
Q5ZPJ1
PDB IDs
2M04
4BPI
4BPJ
4BPK
4HNJ
5UUL
6QFM
6QG8
6TQP
1F16
2G5B
2K7W
2LR1
3PK1
3PL7
4BD2
4BD6
4BD7
4BD8
4BDU
4S0O
4S0P
4UF2
4ZIE
4ZIF
4ZIG
4ZIH
4ZII
5W5X
5W5Z
5W60
5W61
6EB6
6TRR
6XY6
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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