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BBC3 and ZNF438
Data Source:
BioGRID
(two hybrid)
BBC3
ZNF438
Description
BCL2 binding component 3
zinc finger protein 438
Image
No pdb structure
GO Annotations
Cellular Component
Mitochondrion
Lysosome
Nucleus
Nucleoplasm
Cytosol
Molecular Function
Protein Binding
ATPase Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Protein Binding
Metal Ion Binding
Biological Process
Release Of Cytochrome C From Mitochondria
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Execution Phase Of Apoptosis
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Transcription By RNA Polymerase II
Pathways
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Activation of PUMA and translocation to mitochondria
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
FOXO-mediated transcription of cell death genes
Drugs
Diseases
GWAS
Monocyte count (
27863252
)
White blood cell count (
32888494
)
Brain morphology (MOSTest) (
32665545
)
Congenital left-sided heart lesions (maternal effect) (
25138779
)
Heel bone mineral density (
30598549
)
Height (
25429064
31562340
)
Multiple sclerosis (
31604244
21833088
)
Physiological traits (
31902109
)
Pulse pressure (
27841878
)
Response to fenofibrate (triglyceride levels) (
27002377
)
Rheumatoid arthritis (
30423114
24390342
)
Interacting Genes
14 interacting genes:
BAX
BCL2
BCL2A1
BCL2L1
BCL2L2
FHL5
HGS
HSD17B13
MCL1
MYPOP
NDUFAB1
UBASH3B
WDR5
ZNF438
68 interacting genes:
ACOT7
BACH2
BANP
BBC3
BYSL
CDCA7L
CDK18
CEP19
CYSRT1
DMRT3
DPH3
ESRRG
FARS2
FRS3
FXR1
GOLGA2
GOLGA6L9
HAPLN2
KCTD7
KRT40
KRTAP10-1
LGALS14
MAGOHB
MCC
MDFI
MID2
MORF4L1
MORN3
MRPL11
MTUS2
MYLIP
MYO15B
NEK6
NXF1
PIBF1
PICK1
PIH1D2
PLEKHN1
PNMA1
PRMT7
PSMB1
RABEP1
RECK
RPP25
SCNM1
SET
SMARCD1
SPANXN2
SSX2IP
SUV39H1
SYT17
TBC1D22B
TP53BP2
TRAF2
TRAPPC2
TRAPPC2B
TRIM50
TSGA10
TSTD2
YES1
ZBTB8A
ZNF143
ZNF17
ZNF202
ZNF526
ZNF629
ZNF648
ZRANB1
Entrez ID
27113
220929
HPRD ID
16165
11247
Ensembl ID
ENSG00000105327
ENSG00000183621
Uniprot IDs
Q96PG8
Q9BXH1
Q5T427
Q7Z4V0
PDB IDs
2M04
4BPI
4BPJ
4BPK
4HNJ
5UUL
6QFM
6QG8
6TQP
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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