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BBC3 and WDR5
Data Source:
BioGRID
(two hybrid)
BBC3
WDR5
Description
BCL2 binding component 3
WD repeat domain 5
Image
GO Annotations
Cellular Component
Mitochondrion
Lysosome
Histone Acetyltransferase Complex
Nucleus
Nucleoplasm
Ada2/Gcn5/Ada3 Transcription Activator Complex
Histone Methyltransferase Complex
MLL3/4 Complex
Set1C/COMPASS Complex
MLL1 Complex
Molecular Function
Protein Binding
ATPase Binding
Protein Binding
Methylated Histone Binding
Histone Binding
Histone Methyltransferase Activity (H3-K4 Specific)
Biological Process
Release Of Cytochrome C From Mitochondria
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Execution Phase Of Apoptosis
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Skeletal System Development
Neuron Projection Development
Post-translational Protein Modification
Histone H3 Acetylation
Histone H4-K5 Acetylation
Histone H4-K8 Acetylation
Histone H4-K16 Acetylation
Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Gluconeogenesis
Histone H3-K4 Methylation
Positive Regulation Of Histone H3-K4 Methylation
Negative Regulation Of Histone H3-K4 Methylation
Pathways
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Activation of PUMA and translocation to mitochondria
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
FOXO-mediated transcription of cell death genes
PKMTs methylate histone lysines
HATs acetylate histones
HATs acetylate histones
RMTs methylate histone arginines
Activation of anterior HOX genes in hindbrain development during early embryogenesis
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Neddylation
Drugs
Diseases
GWAS
Monocyte count (
27863252
)
White blood cell count (
32888494
)
Cerebrospinal fluid t-tau levels in normal cognition (
29274321
)
Intraocular pressure (
30591961
)
Interacting Genes
14 interacting genes:
BAX
BCL2
BCL2A1
BCL2L1
BCL2L2
FHL5
HGS
HSD17B13
MCL1
MYPOP
NDUFAB1
UBASH3B
WDR5
ZNF438
37 interacting genes:
ANAPC2
APP
ASH2L
ATN1
BBC3
BHLHE41
CHD8
FAM199X
H1-2
H3-4
H3C1
H4-16
HSF2
IKBKG
KANSL1
KANSL2
KMT2A
MARF1
MBIP
MDM4
MEOX2
MLLT1
NR2E3
PDE9A
POU5F1
PRMT5
PRNP
RBBP5
RUSC1-AS1
SRPK2
SRRM4
SSX2IP
TERF2IP
TP53
WWP2
ZBTB48
ZXDC
Entrez ID
27113
11091
HPRD ID
16165
10614
Ensembl ID
ENSG00000105327
ENSG00000196363
Uniprot IDs
Q96PG8
Q9BXH1
P61964
PDB IDs
2M04
4BPI
4BPJ
4BPK
4HNJ
5UUL
6QFM
6QG8
6TQP
2CNX
2CO0
2G99
2G9A
2GNQ
2H13
2H14
2H68
2H6K
2H6N
2H6Q
2H9L
2H9M
2H9N
2H9P
2O9K
3EG6
3EMH
3MXX
3N0D
3N0E
3P4F
3PSL
3SMR
3UR4
3UVK
3UVL
3UVM
3UVN
3UVO
4A7J
4CY1
4CY2
4ERQ
4ERY
4ERZ
4ES0
4ESG
4EWR
4GM3
4GM8
4GM9
4GMB
4IA9
4O45
4QL1
4Y7R
5EAL
5EAM
5EAP
5EAR
5M23
5M25
5SXM
5VFC
6BYN
6D9X
6DAI
6DAK
6DAR
6DAS
6DY7
6DYA
6E1Y
6E1Z
6E22
6E23
6IAM
6KIU
6KIV
6KIW
6KIX
6KIZ
6OFZ
6OI0
6OI1
6OI2
6OI3
6PG3
6PG4
6PG5
6PG6
6PG7
6PG8
6PG9
6PGA
6PGB
6PGC
6PGD
6PGE
6PGF
6PWV
6PWW
6U5M
6U5Y
6U6W
6U80
6U8B
6U8L
6U8O
6UCS
6UFX
6UHY
6UHZ
6UIF
6UIK
6UJ4
6UJH
6UJJ
6UJL
6UOZ
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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