BBC3 and WDR5

Data Source:
BioGRID (two hybrid)

		BBC3	WDR5
Description		BCL2 binding component 3	WD repeat domain 5
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GO Annotations	Cellular Component	Mitochondrion Lysosome	Histone Acetyltransferase Complex Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Histone Methyltransferase Complex MLL3/4 Complex Set1C/COMPASS Complex MLL1 Complex
	Molecular Function	Protein Binding ATPase Binding	Protein Binding Methylated Histone Binding Histone Binding Histone Methyltransferase Activity (H3-K4 Specific)
	Biological Process	Release Of Cytochrome C From Mitochondria Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Release Of Cytochrome C From Mitochondria Execution Phase Of Apoptosis Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Skeletal System Development Neuron Projection Development Post-translational Protein Modification Histone H3 Acetylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Gluconeogenesis Histone H3-K4 Methylation Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K4 Methylation
Pathways		BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release FOXO-mediated transcription of cell death genes	PKMTs methylate histone lysines HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Neddylation
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Diseases
GWAS		Monocyte count ( 27863252) White blood cell count ( 32888494)	Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Intraocular pressure ( 30591961)
Interacting Genes		14 interacting genes: BAX BCL2 BCL2A1 BCL2L1 BCL2L2 FHL5 HGS HSD17B13 MCL1 MYPOP NDUFAB1 UBASH3B WDR5 ZNF438	37 interacting genes: ANAPC2 APP ASH2L ATN1 BBC3 BHLHE41 CHD8 FAM199X H1-2 H3-4 H3C1 H4-16 HSF2 IKBKG KANSL1 KANSL2 KMT2A MARF1 MBIP MDM4 MEOX2 MLLT1 NR2E3 PDE9A POU5F1 PRMT5 PRNP RBBP5 RUSC1-AS1 SRPK2 SRRM4 SSX2IP TERF2IP TP53 WWP2 ZBTB48 ZXDC
Entrez ID		27113	11091
HPRD ID		16165	10614
Ensembl ID		ENSG00000105327	ENSG00000196363
Uniprot IDs		Q96PG8 Q9BXH1	P61964
PDB IDs		2M04 4BPI 4BPJ 4BPK 4HNJ 5UUL 6QFM 6QG8 6TQP	2CNX 2CO0 2G99 2G9A 2GNQ 2H13 2H14 2H68 2H6K 2H6N 2H6Q 2H9L 2H9M 2H9N 2H9P 2O9K 3EG6 3EMH 3MXX 3N0D 3N0E 3P4F 3PSL 3SMR 3UR4 3UVK 3UVL 3UVM 3UVN 3UVO 4A7J 4CY1 4CY2 4ERQ 4ERY 4ERZ 4ES0 4ESG 4EWR 4GM3 4GM8 4GM9 4GMB 4IA9 4O45 4QL1 4Y7R 5EAL 5EAM 5EAP 5EAR 5M23 5M25 5SXM 5VFC 6BYN 6D9X 6DAI 6DAK 6DAR 6DAS 6DY7 6DYA 6E1Y 6E1Z 6E22 6E23 6IAM 6KIU 6KIV 6KIW 6KIX 6KIZ 6OFZ 6OI0 6OI1 6OI2 6OI3 6PG3 6PG4 6PG5 6PG6 6PG7 6PG8 6PG9 6PGA 6PGB 6PGC 6PGD 6PGE 6PGF 6PWV 6PWW 6U5M 6U5Y 6U6W 6U80 6U8B 6U8L 6U8O 6UCS 6UFX 6UHY 6UHZ 6UIF 6UIK 6UJ4 6UJH 6UJJ 6UJL 6UOZ
Enriched GO Terms of Interacting Partners?
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