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ATXN3 and UBQLN1
Data Source:
HPRD
(in vitro)
ATXN3
UBQLN1
Description
ataxin 3
ubiquilin 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Mitochondrial Matrix
Endoplasmic Reticulum Membrane
Cytosol
Plasma Membrane
Nuclear Matrix
Mitochondrial Membrane
Nuclear Inclusion Body
Synapse
Proteasome Complex
Nucleoplasm
Cytoplasm
Autophagosome
Endoplasmic Reticulum
Cytosol
Plasma Membrane
Aggresome
Cytoplasmic Vesicle
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Molecular Function
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
Cysteine-type Peptidase Activity
Ubiquitin Protein Ligase Binding
ATPase Binding
Lys63-specific Deubiquitinase Activity
Lys48-specific Deubiquitinase Activity
Protein Binding
Kinase Binding
Polyubiquitin Modification-dependent Protein Binding
Identical Protein Binding
Biological Process
Microtubule Cytoskeleton Organization
Nucleotide-excision Repair
Ubiquitin-dependent Protein Catabolic Process
Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins
Chemical Synaptic Transmission
Nervous System Development
Regulation Of Cell-substrate Adhesion
Protein Deubiquitination
Protein Phosphopantetheinylation
Actin Cytoskeleton Organization
Cellular Response To Heat
Monoubiquitinated Protein Deubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Intermediate Filament Cytoskeleton Organization
Protein K63-linked Deubiquitination
Protein K48-linked Deubiquitination
Cellular Response To Misfolded Protein
Positive Regulation Of ERAD Pathway
Protein Localization To Cytosolic Proteasome Complex Involved In ERAD Pathway
Autophagosome Assembly
Ubiquitin-dependent Protein Catabolic Process
Macroautophagy
Regulation Of Macroautophagy
Ubiquitin-dependent ERAD Pathway
Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Response To Endoplasmic Reticulum Stress
Aggrephagy
Cellular Response To Hypoxia
Autophagosome Maturation
Negative Regulation Of Store-operated Calcium Channel Activity
Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process
Pathways
Josephin domain DUBs
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Cargo recognition for clathrin-mediated endocytosis
Drugs
Diseases
Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS
Amyotrophic lateral sclerosis (
29566793
)
Coronary artery calcification (
23870195
)
HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction (
31806883
)
Height (
18391950
18391951
)
LDL cholesterol levels x loop diuretics use interaction (
31806883
)
Orofacial clefts (
22419666
)
Refractive error (
32231278
)
Metabolite levels (
23823483
)
Refractive error (
32231278
)
Interacting Genes
53 interacting genes:
ANXA7
APP
ARHGAP19
ARHGDIA
ASIC1
CAPN1
CAPN2
CASP1
CDKN1A
CHEK1
CSNK2B
DNM2
EWSR1
GABARAP
GSK3B
HDAC6
KAT2B
MAP1LC3A
MAP1LC3C
MAP3K1
MKNK1
NCOR1
NEDD8
PHAF1
PICK1
PJA1
PRKN
PSMD7
RAD23A
RAD23B
RFFL
RPS6KA1
SMURF1
SQSTM1
STUB1
SUMO1
TEX11
TK1
TP53
TRAF6
TRIM54
TRIM55
TRIM63
TUBA1A
TUBB
UBB
UBC
UBE2L3
UBE2S
UBE4B
UBQLN1
USP21
VCP
233 interacting genes:
ABCC2
ACOT7
ADRM1
AGPAT5
AGR2
AGR3
ANOS1
APOC2
APOC4
APP
ASCL1
ATXN3
BAG6
BPIFA1
C1QA
C1QTNF2
C1QTNF4
CALU
CCL3
CCL7
CD47
CD99
CD99L2
CDIP1
CDSN
CHGB
CHRNA3
CHRNA4
CHRNB4
CLCN2
COL10A1
COL1A2
COL9A2
COLGALT2
COMTD1
COPS4
CSN3
CSTF2
CSTF2T
CTAG1A
CTAG1B
CTAG2
CYB5R1
DAZAP2
DEFA6
DEFB115
DESI1
DEXI
DMKN
DNAJB2
DOLK
ECM1
EFEMP2
EP300
EPS15
ERP27
ERP29
ETNK1
F8
FAM163B
FAM189A2
FAM86B3P
FAS
FBXO25
FCGR2A
FGF7
FKBP2
FN1
FOLR3
FZD7
GABRA1
GABRA2
GABRA3
GABRA6
GABRB1
GABRB2
GABRB3
GABRD
GAL
GHRL
GIT2
GKAP1
GPR162
GPX3
GRM2
GUCA2A
GUCA2B
GYPB
HERC3
HES1
HGS
HK2
HSD17B12
HSPA13
IER3IP1
IGFBP6
IGL
IGLC1
IGLV2-14
IL6ST
IRF1-AS1
IST1
ITPRIPL1
JPH4
JSRP1
KLHL42
LAIR2
LAMB1
LCN2
LHX4
LITAF
LNPEP
MANBAL
MAP3K1
MCM7
MDK
MESD
MICOS10-NBL1
MIEF1
MIEF2
MLLT6
MTNR1A
MTOR
MYDGF
NAXD
NBL1
NDE1
NDOR1
NEDD8
NGLY1
NLGN3
NME3
NPPA
NPY
NT5C3A
NUP58
NXF1
OST4
P4HB
PARVA
PBXIP1
PCDH18
PCDHA4
PIAS2
PIK3IP1
PLAAT1
PLAAT2
PLAAT3
PNMA1
PPIB
PPIC
PRAP1
PRB1
PRPF40A
PRR4
PSEN1
PSEN2
PSMD4
PSMD6
PSORS1C2
PTN
RAI2
RARA
RASSF5
RIC8A
RNF144B
RNF208
RNF4
RPN1
RPS27A
RSRC2
RTL8A
RTL8B
RTL8C
SCG2
SCG5
SCMH1
SERPINE1
SERPINI2
SEZ6L
SIL1
SLC16A3
SLC29A2
SLPI
SMAD9
SMIM19
SMIM2
SMR3B
SMURF1
SOD3
SPAG8
SPARC
SRGN
STAM2
STMN3
SYNJ2BP
TARDBP
TFF1
TICAM1
TLR4
TMCO6
TMEM258
TMEM31
TMEM37
TMEM67
TMUB2
TNFRSF1A
TNFRSF1B
TREX1
TRIM23
TRIM32
TXNDC12
UBA52
UBB
UBC
UBE2I
UBE2V1
UBE3A
UBQLN2
UBQLN4
UBXN1
UBXN4
UBXN7
VWC2
WBP2
WFDC12
XPO4
ZBTB8B
ZFAND2B
ZG16
ZG16B
ZMYM5
ZNF343
Entrez ID
4287
29979
HPRD ID
06131
05440
Ensembl ID
ENSG00000066427
ENSG00000135018
Uniprot IDs
A0A0A0MS38
C9JQV6
P54252
A0A024R258
Q9UMX0
PDB IDs
1YZB
2AGA
2DOS
2JRI
2KLZ
4WTH
4YS9
2JY5
2JY6
2KLC
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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