ATXN3 and ARHGAP19

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ATXN3	ARHGAP19
Description		ataxin 3	Rho GTPase activating protein 19
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrial Matrix Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Nuclear Matrix Mitochondrial Membrane Nuclear Inclusion Body Synapse	Nucleus Cytoplasm Cytosol Plasma Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity Ubiquitin Protein Ligase Binding ATPase Binding Lys63-specific Deubiquitinase Activity Lys48-specific Deubiquitinase Activity	GTPase Activator Activity Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Nucleotide-excision Repair Ubiquitin-dependent Protein Catabolic Process Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Chemical Synaptic Transmission Nervous System Development Regulation Of Cell-substrate Adhesion Protein Deubiquitination Protein Phosphopantetheinylation Actin Cytoskeleton Organization Cellular Response To Heat Monoubiquitinated Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intermediate Filament Cytoskeleton Organization Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Cellular Response To Misfolded Protein Positive Regulation Of ERAD Pathway Protein Localization To Cytosolic Proteasome Complex Involved In ERAD Pathway	Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Josephin domain DUBs FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	Rho GTPase cycle
Drugs
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Amyotrophic lateral sclerosis ( 29566793) Coronary artery calcification ( 23870195) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Height ( 18391950 18391951) LDL cholesterol levels x loop diuretics use interaction ( 31806883) Orofacial clefts ( 22419666) Refractive error ( 32231278)	Adventurousness ( 30643258) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Type 2 diabetes ( 32499647)
Interacting Genes		53 interacting genes: ANXA7 APP ARHGAP19 ARHGDIA ASIC1 CAPN1 CAPN2 CASP1 CDKN1A CHEK1 CSNK2B DNM2 EWSR1 GABARAP GSK3B HDAC6 KAT2B MAP1LC3A MAP1LC3C MAP3K1 MKNK1 NCOR1 NEDD8 PHAF1 PICK1 PJA1 PRKN PSMD7 RAD23A RAD23B RFFL RPS6KA1 SMURF1 SQSTM1 STUB1 SUMO1 TEX11 TK1 TP53 TRAF6 TRIM54 TRIM55 TRIM63 TUBA1A TUBB UBB UBC UBE2L3 UBE2S UBE4B UBQLN1 USP21 VCP	2 interacting genes: ATXN3 RHOA
Entrez ID		4287	84986
HPRD ID		06131	12475
Ensembl ID		ENSG00000066427	ENSG00000213390
Uniprot IDs		A0A0A0MS38 C9JQV6 P54252	Q14CB8
PDB IDs		1YZB 2AGA 2DOS 2JRI 2KLZ 4WTH 4YS9
Enriched GO Terms of Interacting Partners?
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