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MDK and STAT1
Data Source:
HPRD
(in vitro)
MDK
STAT1
Description
midkine
signal transducer and activator of transcription 1
Image
GO Annotations
Cellular Component
Extracellular Region
Collagen-containing Extracellular Matrix
Chromatin
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Axon
Dendrite
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Molecular Function
Protein Binding
Growth Factor Activity
Heparin Binding
Chondroitin Sulfate Binding
Heparan Sulfate Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Double-stranded DNA Binding
DNA-binding Transcription Factor Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Enzyme Binding
Histone Acetyltransferase Binding
Nuclear Hormone Receptor Binding
Histone Binding
Identical Protein Binding
Protein Homodimerization Activity
Ubiquitin-like Protein Ligase Binding
Cadherin Binding
Repressing Transcription Factor Binding
Promoter-specific Chromatin Binding
Biological Process
Leukocyte Chemotaxis Involved In Inflammatory Response
T Cell Activation Involved In Immune Response
Positive Regulation Of Leukocyte Chemotaxis
Cytoskeleton Organization
Negative Regulation Of Cell Adhesion
Signal Transduction
Notch Signaling Pathway
Nervous System Development
Response To Wounding
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Macrophage Chemotaxis
Positive Regulation Of Keratinocyte Proliferation
Positive Regulation Of Neuron Projection Development
Response To Auditory Stimulus
Cell Differentiation
Negative Regulation Of Ossification
Adrenal Gland Development
Positive Regulation Of Cell Migration
Regulation Of Chondrocyte Differentiation
Positive Regulation Of Interleukin-12 Production
Tissue Regeneration
Negative Regulation Of Neuron Apoptotic Process
Estrous Cycle
Positive Regulation Of T Cell Differentiation
Negative Regulation Of Regulatory T Cell Differentiation
Positive Regulation Of Cell Adhesion
Regulation Of Bone Remodeling
Oogenesis
Positive Regulation Of Oligodendrocyte Differentiation
Positive Regulation Of Inflammatory Response
Positive Regulation Of Cell Division
Positive Regulation Of Cartilage Development
Positive Regulation Of Smooth Muscle Cell Chemotaxis
Positive Regulation Of Neutrophil Chemotaxis
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Inflammatory Response To Wounding
Positive Regulation Of Inflammatory Response To Wounding
Glial Cell Projection Elongation
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Leukocyte Cell-cell Adhesion
Negative Regulation Of Epithelial Cell Apoptotic Process
Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Positive Regulation Of Blood Vessel Branching
Positive Regulation Of Vascular Endothelial Cell Proliferation
Positive Regulation Of Artery Morphogenesis
Positive Regulation Of Neural Precursor Cell Proliferation
Regulation Of Actin Cytoskeleton Reorganization
Positive Regulation Of Hepatocyte Proliferation
Positive Regulation Of Neutrophil Extravasation
Positive Regulation Of Neuron Migration
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Endothelial Cell Proliferation
Positive Regulation Of Mesenchymal Cell Proliferation
Positive Regulation Of Defense Response To Virus By Host
Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis
Defense Response
Positive Regulation Of Transcription Of Notch Receptor Target
Receptor Signaling Pathway Via JAK-STAT
Blood Circulation
Macrophage Derived Foam Cell Differentiation
Viral Process
Negative Regulation Of Angiogenesis
Cytokine-mediated Signaling Pathway
Positive Regulation Of Interferon-alpha Production
Tumor Necrosis Factor-mediated Signaling Pathway
Response To Cytokine
Response To Interferon-beta
Cellular Response To Interferon-beta
Interleukin-9-mediated Signaling Pathway
Interleukin-21-mediated Signaling Pathway
Regulation Of Cell Population Proliferation
Regulation Of Apoptotic Process
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Response To Peptide Hormone
Endothelial Cell Migration
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation By Virus Of Viral Protein Levels In Host Cell
Positive Regulation Of Smooth Muscle Cell Proliferation
Response To CAMP
Defense Response To Virus
Interferon-gamma-mediated Signaling Pathway
Regulation Of Interferon-gamma-mediated Signaling Pathway
Type I Interferon Signaling Pathway
Renal Tubule Development
Interleukin-6-mediated Signaling Pathway
Interleukin-27-mediated Signaling Pathway
Interleukin-35-mediated Signaling Pathway
Cellular Response To Interferon-gamma
Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development
Metanephric Mesenchymal Cell Differentiation
Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation
Pathways
NOTCH2 Activation and Transmission of Signal to the Nucleus
Interleukin-6 signaling
ISG15 antiviral mechanism
Signaling by SCF-KIT
Signaling by cytosolic FGFR1 fusion mutants
Downstream signal transduction
Interleukin-4 and Interleukin-13 signaling
Interleukin-20 family signaling
Regulation of RUNX2 expression and activity
Interleukin-35 Signalling
Interleukin-9 signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH3 Intracellular Domain Regulates Transcription
Interleukin-27 signaling
Interleukin-21 signaling
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Growth hormone receptor signaling
Drugs
Diseases
Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
GWAS
Alzheimer's disease or fasting glucose levels (pleiotropy) (
30805717
)
Autism spectrum disorder or schizophrenia (
28540026
)
Feeling miserable (
29500382
)
Immunoglobulin A (
20694011
)
Schizophrenia (
28991256
29483656
30285260
)
Birth weight (
31043758
)
Height (
31562340
)
Inflammatory bowel disease (
23128233
)
JT interval (sulfonylurea treatment interaction) (
27958378
)
Limited cutaneous systemic scleroderma (
29293537
)
Lung cancer (SNP x SNP interaction) (
24325914
)
Metabolite levels (
23823483
)
Neutrophil percentage of granulocytes (
27863252
)
Primary biliary cholangitis (
28425483
26394269
)
Primary biliary cirrhosis (
22961000
)
Systemic lupus erythematosus (
26316170
)
Systemic sclerosis (
29293537
)
Interacting Genes
32 interacting genes:
ALK
AP1M1
CDC42
FBXO7
HCK
JAK1
JAK2
JOSD2
LRP1
LRP2
LRP6
LRP8
MAPK6
MIEF2
NCL
NFU1
PBX3
PTPRZ1
RBFA
RPL18A
SDC1
SDC3
SDC4
SRPK2
STAT1
TCEA2
TGM1
TMED8
TSPAN1
UBQLN1
UBQLN2
UBQLN4
108 interacting genes:
ACTN4
ADRA1B
AKT1
ATF3
BMX
BRCA1
CAMK2D
CAMK2G
CASP3
CASP7
CCR1
CCR5
CDC42
CREBBP
CSE1L
CSF2RB
CXCR4
DCTN1
DDB1
DDX6
DOT1L
DUSP2
DUSP3
E2F1
EGFR
EIF1AD
EIF2AK2
ELP2
EP300
FADD
FANCC
FGFR3
FGFR4
FLT1
FOS
FTH1
FYN
GFAP
GTF2I
HADH
HLA-B
HSF1
HSP90AB1
HSPA8
IFNAR2
IFNGR1
IL27RA
IL2RB
IL2RG
IRF1
IRF2
IRF9
JAK1
JAK2
JUN
KDR
KIT
KPNA1
KPNA6
LCK
LMO2
LZTR1
MAPK14
MAVS
MCM3
MCM5
MDK
MT-ND4L
NMI
NOMO1
NOMO2
OTUD4
PDGFRA
PDGFRB
PIAS1
PIK3CA
POR
PRKCD
PRMT1
PRMT3
PTK2
PTPN11
PTPN2
RAC1
RACK1
RELA
RPS6KA5
RXRA
SHANK1
SPTAN1
SPTB
SPTBN1
SRC
STAT2
STAT3
STAT4
STAT5A
STAT5B
SUMO4
SYK
TNFRSF1A
TNFRSF1B
TRADD
TYK2
UBE2I
VDR
XPO1
ZNF467
Entrez ID
4192
6772
HPRD ID
01200
02777
Ensembl ID
ENSG00000110492
ENSG00000115415
Uniprot IDs
P21741
P42224
PDB IDs
1MKC
1MKN
1BF5
1YVL
2KA6
3WWT
Enriched GO Terms of Interacting Partners
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