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MDK and SDC4
Data Source:
HPRD
(in vitro)
MDK
SDC4
Description
midkine
syndecan 4
Image
GO Annotations
Cellular Component
Extracellular Region
Collagen-containing Extracellular Matrix
Golgi Lumen
Plasma Membrane
Integral Component Of Plasma Membrane
Focal Adhesion
Cell Surface
Costamere
Lysosomal Lumen
Membrane Raft
Extracellular Exosome
Molecular Function
Protein Binding
Growth Factor Activity
Heparin Binding
Chondroitin Sulfate Binding
Heparan Sulfate Binding
Fibronectin Binding
Protein Kinase C Binding
Protein Binding
Identical Protein Binding
Thrombospondin Receptor Activity
Biological Process
Leukocyte Chemotaxis Involved In Inflammatory Response
T Cell Activation Involved In Immune Response
Positive Regulation Of Leukocyte Chemotaxis
Cytoskeleton Organization
Negative Regulation Of Cell Adhesion
Signal Transduction
Notch Signaling Pathway
Nervous System Development
Response To Wounding
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Macrophage Chemotaxis
Positive Regulation Of Keratinocyte Proliferation
Positive Regulation Of Neuron Projection Development
Response To Auditory Stimulus
Cell Differentiation
Negative Regulation Of Ossification
Adrenal Gland Development
Positive Regulation Of Cell Migration
Regulation Of Chondrocyte Differentiation
Positive Regulation Of Interleukin-12 Production
Tissue Regeneration
Negative Regulation Of Neuron Apoptotic Process
Estrous Cycle
Positive Regulation Of T Cell Differentiation
Negative Regulation Of Regulatory T Cell Differentiation
Positive Regulation Of Cell Adhesion
Regulation Of Bone Remodeling
Oogenesis
Positive Regulation Of Oligodendrocyte Differentiation
Positive Regulation Of Inflammatory Response
Positive Regulation Of Cell Division
Positive Regulation Of Cartilage Development
Positive Regulation Of Smooth Muscle Cell Chemotaxis
Positive Regulation Of Neutrophil Chemotaxis
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Inflammatory Response To Wounding
Positive Regulation Of Inflammatory Response To Wounding
Glial Cell Projection Elongation
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Leukocyte Cell-cell Adhesion
Negative Regulation Of Epithelial Cell Apoptotic Process
Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Positive Regulation Of Blood Vessel Branching
Positive Regulation Of Vascular Endothelial Cell Proliferation
Positive Regulation Of Artery Morphogenesis
Positive Regulation Of Neural Precursor Cell Proliferation
Regulation Of Actin Cytoskeleton Reorganization
Positive Regulation Of Hepatocyte Proliferation
Positive Regulation Of Neutrophil Extravasation
Positive Regulation Of Neuron Migration
Retinoid Metabolic Process
Ureteric Bud Development
Neural Tube Closure
Glycosaminoglycan Biosynthetic Process
Glycosaminoglycan Catabolic Process
Regulation Of Fibroblast Migration
Cell Migration
Wound Healing
Negative Regulation Of T Cell Proliferation
Positive Regulation Of Protein Kinase Activity
Leukocyte Migration
Positive Regulation Of Stress Fiber Assembly
Positive Regulation Of Focal Adhesion Assembly
Inner Ear Receptor Cell Stereocilium Organization
Positive Regulation Of Exosomal Secretion
Positive Regulation Of Extracellular Exosome Assembly
Pathways
NOTCH2 Activation and Transmission of Signal to the Nucleus
A tetrasaccharide linker sequence is required for GAG synthesis
HS-GAG biosynthesis
HS-GAG biosynthesis
HS-GAG degradation
Cell surface interactions at the vascular wall
Syndecan interactions
Syndecan interactions
Defective B4GALT7 causes EDS, progeroid type
Defective B3GAT3 causes JDSSDHD
Defective EXT2 causes exostoses 2
Defective EXT1 causes exostoses 1, TRPS2 and CHDS
Defective B3GALT6 causes EDSP2 and SEMDJL1
Retinoid metabolism and transport
Drugs
Diseases
GWAS
Alzheimer's disease or fasting glucose levels (pleiotropy) (
30805717
)
Autism spectrum disorder or schizophrenia (
28540026
)
Feeling miserable (
29500382
)
Immunoglobulin A (
20694011
)
Schizophrenia (
28991256
29483656
30285260
)
Malaria (
31844061
)
Psoriasis (
20953189
)
Interacting Genes
32 interacting genes:
ALK
AP1M1
CDC42
FBXO7
HCK
JAK1
JAK2
JOSD2
LRP1
LRP2
LRP6
LRP8
MAPK6
MIEF2
NCL
NFU1
PBX3
PTPRZ1
RBFA
RPL18A
SDC1
SDC3
SDC4
SRPK2
STAT1
TCEA2
TGM1
TMED8
TSPAN1
UBQLN1
UBQLN2
UBQLN4
19 interacting genes:
CASK
CCL5
CXCR4
GIPC1
IL7R
MAL
MDK
PMP22
PRKCA
PRKCD
PTEN
PXN
SDCBP
SGTA
SGTB
TANK
TGFB1I1
TGFB3
UBC
Entrez ID
4192
6385
HPRD ID
01200
08366
Ensembl ID
ENSG00000110492
ENSG00000124145
Uniprot IDs
P21741
B4E1S6
P31431
PDB IDs
1MKC
1MKN
1EJP
1EJQ
1OBY
1YBO
Enriched GO Terms of Interacting Partners
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