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STAT1 and PRMT1
Data Source:
BioGRID
(enzymatic study, affinity chromatography technology)
HPRD
(in vitro, in vivo)
STAT1
PRMT1
Description
signal transducer and activator of transcription 1
protein arginine methyltransferase 1
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Axon
Dendrite
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Methylosome
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Double-stranded DNA Binding
DNA-binding Transcription Factor Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Enzyme Binding
Histone Acetyltransferase Binding
Nuclear Hormone Receptor Binding
Histone Binding
Identical Protein Binding
Protein Homodimerization Activity
Ubiquitin-like Protein Ligase Binding
Cadherin Binding
Repressing Transcription Factor Binding
Promoter-specific Chromatin Binding
RNA Binding
Protein Binding
Methyltransferase Activity
N-methyltransferase Activity
Protein Methyltransferase Activity
Methyl-CpG Binding
Protein-arginine N-methyltransferase Activity
Enzyme Binding
Protein-arginine Omega-N Monomethyltransferase Activity
Protein-arginine Omega-N Asymmetric Methyltransferase Activity
Histone Methyltransferase Activity
Identical Protein Binding
Histone Methyltransferase Activity (H4-R3 Specific)
Mitogen-activated Protein Kinase P38 Binding
S-adenosyl-L-methionine Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Endothelial Cell Proliferation
Positive Regulation Of Mesenchymal Cell Proliferation
Positive Regulation Of Defense Response To Virus By Host
Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis
Defense Response
Positive Regulation Of Transcription Of Notch Receptor Target
Receptor Signaling Pathway Via JAK-STAT
Blood Circulation
Macrophage Derived Foam Cell Differentiation
Viral Process
Negative Regulation Of Angiogenesis
Cytokine-mediated Signaling Pathway
Positive Regulation Of Interferon-alpha Production
Tumor Necrosis Factor-mediated Signaling Pathway
Response To Cytokine
Response To Interferon-beta
Cellular Response To Interferon-beta
Interleukin-9-mediated Signaling Pathway
Interleukin-21-mediated Signaling Pathway
Regulation Of Cell Population Proliferation
Regulation Of Apoptotic Process
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Response To Peptide Hormone
Endothelial Cell Migration
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation By Virus Of Viral Protein Levels In Host Cell
Positive Regulation Of Smooth Muscle Cell Proliferation
Response To CAMP
Defense Response To Virus
Interferon-gamma-mediated Signaling Pathway
Regulation Of Interferon-gamma-mediated Signaling Pathway
Type I Interferon Signaling Pathway
Renal Tubule Development
Interleukin-6-mediated Signaling Pathway
Interleukin-27-mediated Signaling Pathway
Interleukin-35-mediated Signaling Pathway
Cellular Response To Interferon-gamma
Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development
Metanephric Mesenchymal Cell Differentiation
Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation
In Utero Embryonic Development
Protein Methylation
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Histone Methylation
Peptidyl-arginine Methylation
Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine
Neuron Projection Development
Histone H4-R3 Methylation
Positive Regulation Of Erythrocyte Differentiation
Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Hemoglobin Biosynthetic Process
Protein Homooligomerization
Positive Regulation Of P38MAPK Cascade
Pathways
Interleukin-6 signaling
ISG15 antiviral mechanism
Signaling by SCF-KIT
Signaling by cytosolic FGFR1 fusion mutants
Downstream signal transduction
Interleukin-4 and Interleukin-13 signaling
Interleukin-20 family signaling
Regulation of RUNX2 expression and activity
Interleukin-35 Signalling
Interleukin-9 signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH3 Intracellular Domain Regulates Transcription
Interleukin-27 signaling
Interleukin-21 signaling
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Growth hormone receptor signaling
RMTs methylate histone arginines
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Extra-nuclear estrogen signaling
Estrogen-dependent gene expression
Drugs
S-adenosyl-L-homocysteine
Diseases
Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
GWAS
Birth weight (
31043758
)
Height (
31562340
)
Inflammatory bowel disease (
23128233
)
JT interval (sulfonylurea treatment interaction) (
27958378
)
Limited cutaneous systemic scleroderma (
29293537
)
Lung cancer (SNP x SNP interaction) (
24325914
)
Metabolite levels (
23823483
)
Neutrophil percentage of granulocytes (
27863252
)
Primary biliary cholangitis (
28425483
26394269
)
Primary biliary cirrhosis (
22961000
)
Systemic lupus erythematosus (
26316170
)
Systemic sclerosis (
29293537
)
Schizophrenia (
29483656
)
Interacting Genes
108 interacting genes:
ACTN4
ADRA1B
AKT1
ATF3
BMX
BRCA1
CAMK2D
CAMK2G
CASP3
CASP7
CCR1
CCR5
CDC42
CREBBP
CSE1L
CSF2RB
CXCR4
DCTN1
DDB1
DDX6
DOT1L
DUSP2
DUSP3
E2F1
EGFR
EIF1AD
EIF2AK2
ELP2
EP300
FADD
FANCC
FGFR3
FGFR4
FLT1
FOS
FTH1
FYN
GFAP
GTF2I
HADH
HLA-B
HSF1
HSP90AB1
HSPA8
IFNAR2
IFNGR1
IL27RA
IL2RB
IL2RG
IRF1
IRF2
IRF9
JAK1
JAK2
JUN
KDR
KIT
KPNA1
KPNA6
LCK
LMO2
LZTR1
MAPK14
MAVS
MCM3
MCM5
MDK
MT-ND4L
NMI
NOMO1
NOMO2
OTUD4
PDGFRA
PDGFRB
PIAS1
PIK3CA
POR
PRKCD
PRMT1
PRMT3
PTK2
PTPN11
PTPN2
RAC1
RACK1
RELA
RPS6KA5
RXRA
SHANK1
SPTAN1
SPTB
SPTBN1
SRC
STAT2
STAT3
STAT4
STAT5A
STAT5B
SUMO4
SYK
TNFRSF1A
TNFRSF1B
TRADD
TYK2
UBE2I
VDR
XPO1
ZNF467
151 interacting genes:
AR
ARPC3
ASH2L
AXIN1
BRCA1
BTG1
BTG2
C4orf17
CAPRIN1
CDC37
CEP162
CIRBP
CNOT8
COIL
DAXX
DCAF16
DCAF8
DHX9
EIF4A1
EP300
ESR1
EWSR1
FAM83D
FAM9A
FBL
FBXL17
FBXO7
FGF2
FLII
FUS
GLI1
GPATCH2L
GRHL3
GRIP1
H3C1
H4-16
H4C14
HABP4
HNF4A
HNRNPA1
HNRNPK
HNRNPR
HNRNPU
HNRNPUL1
HROB
IDH3B
IFNAR1
IGSF21
ILF3
KHDRBS1
KHDRBS2
KHDRBS3
LRIF1
MBP
MECOM
MED31
MIR1-1
MIR1-2
MIR106A
MIR106B
MIR107
MIR10B
MIR122
MIR128-1
MIR138-1
MIR141
MIR143
MIR145
MIR155
MIR15A
MIR15B
MIR16-1
MIR16-2
MIR17
MIR18B
MIR199A1
MIR199A2
MIR19A
MIR19B1
MIR19B2
MIR200A
MIR200B
MIR206
MIR20A
MIR20B
MIR221
MIR222
MIR25
MIR29A
MIR29B1
MIR29B2
MIR29C
MIR34A
MIR34C
MIR363
MIR451A
MIR7-3
MIR9-1
MIR9-2
MIR9-3
MIR92A1
MIR92A2
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7D
MIRLET7E
MIRLET7F1
MIRLET7F2
MLST8
NCOA1
NCOA2
NCOA3
NOL4
NRIP1
NTAQ1
OFCC1
PPARA
PRMT8
QKI
RBM15
RELA
RNF187
RUNX1
S100A8
SAMD3
SHLD1
SIRT1
SPAG8
SPEG
SPSB1
SPSB2
STAT1
STAT5A
STUB1
SUPT5H
TBX6
TERF2
THRB
TP53
TRIM48
UBE4B
VHL
VPS72
WDFY3
WDR33
YLPM1
YWHAG
ZBTB14
ZMYM5
ZNF451
Entrez ID
6772
3276
HPRD ID
02777
04257
Ensembl ID
ENSG00000115415
ENSG00000126457
Uniprot IDs
P42224
Q99873
PDB IDs
1BF5
1YVL
2KA6
3WWT
6NT2
Enriched GO Terms of Interacting Partners
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