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STAT1 and TNFRSF1B
Data Source:
HPRD
(in vitro, in vivo)
STAT1
TNFRSF1B
Description
signal transducer and activator of transcription 1
TNF receptor superfamily member 1B
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Axon
Dendrite
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Tumor Necrosis Factor Receptor Superfamily Complex
Extracellular Region
Nucleus
Plasma Membrane
Membrane
Integral Component Of Membrane
Specific Granule Membrane
Neuronal Cell Body
Varicosity
Membrane Raft
Perinuclear Region Of Cytoplasm
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Double-stranded DNA Binding
DNA-binding Transcription Factor Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Enzyme Binding
Histone Acetyltransferase Binding
Nuclear Hormone Receptor Binding
Histone Binding
Identical Protein Binding
Protein Homodimerization Activity
Ubiquitin-like Protein Ligase Binding
Cadherin Binding
Repressing Transcription Factor Binding
Promoter-specific Chromatin Binding
Tumor Necrosis Factor-activated Receptor Activity
Protein Binding
Ubiquitin Protein Ligase Binding
Tumor Necrosis Factor Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Endothelial Cell Proliferation
Positive Regulation Of Mesenchymal Cell Proliferation
Positive Regulation Of Defense Response To Virus By Host
Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis
Defense Response
Positive Regulation Of Transcription Of Notch Receptor Target
Receptor Signaling Pathway Via JAK-STAT
Blood Circulation
Macrophage Derived Foam Cell Differentiation
Viral Process
Negative Regulation Of Angiogenesis
Cytokine-mediated Signaling Pathway
Positive Regulation Of Interferon-alpha Production
Tumor Necrosis Factor-mediated Signaling Pathway
Response To Cytokine
Response To Interferon-beta
Cellular Response To Interferon-beta
Interleukin-9-mediated Signaling Pathway
Interleukin-21-mediated Signaling Pathway
Regulation Of Cell Population Proliferation
Regulation Of Apoptotic Process
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Response To Peptide Hormone
Endothelial Cell Migration
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation By Virus Of Viral Protein Levels In Host Cell
Positive Regulation Of Smooth Muscle Cell Proliferation
Response To CAMP
Defense Response To Virus
Interferon-gamma-mediated Signaling Pathway
Regulation Of Interferon-gamma-mediated Signaling Pathway
Type I Interferon Signaling Pathway
Renal Tubule Development
Interleukin-6-mediated Signaling Pathway
Interleukin-27-mediated Signaling Pathway
Interleukin-35-mediated Signaling Pathway
Cellular Response To Interferon-gamma
Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development
Metanephric Mesenchymal Cell Differentiation
Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation
Regulation Of Cytokine Production Involved In Immune Response
Regulation Of T Cell Cytokine Production
Aortic Valve Development
Pulmonary Valve Development
Negative Regulation Of Extracellular Matrix Constituent Secretion
Inflammatory Response
Aging
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Negative Regulation Of Cardiac Muscle Hypertrophy
Cytokine-mediated Signaling Pathway
Regulation Of Myelination
Positive Regulation Of Myelination
Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of T Cell Proliferation
Neutrophil Degranulation
Positive Regulation Of Oligodendrocyte Differentiation
RNA Destabilization
Positive Regulation Of Membrane Protein Ectodomain Proteolysis
Negative Regulation Of Cell Death
Cellular Response To Lipopolysaccharide
Cellular Response To Growth Factor Stimulus
Extrinsic Apoptotic Signaling Pathway
Regulation Of Neuroinflammatory Response
Negative Regulation Of Neuroinflammatory Response
Glial Cell-neuron Signaling
Negative Regulation Of Neuron Death
Positive Regulation Of Apoptotic Process Involved In Morphogenesis
Regulation Of RNA Biosynthetic Process
Pathways
Interleukin-6 signaling
ISG15 antiviral mechanism
Signaling by SCF-KIT
Signaling by cytosolic FGFR1 fusion mutants
Downstream signal transduction
Interleukin-4 and Interleukin-13 signaling
Interleukin-20 family signaling
Regulation of RUNX2 expression and activity
Interleukin-35 Signalling
Interleukin-9 signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH3 Intracellular Domain Regulates Transcription
Interleukin-27 signaling
Interleukin-21 signaling
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Growth hormone receptor signaling
TNFR2 non-canonical NF-kB pathway
TNFs bind their physiological receptors
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Neutrophil degranulation
Drugs
Tasonermin
Diseases
Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
Graft-versus-host disease
GWAS
Birth weight (
31043758
)
Height (
31562340
)
Inflammatory bowel disease (
23128233
)
JT interval (sulfonylurea treatment interaction) (
27958378
)
Limited cutaneous systemic scleroderma (
29293537
)
Lung cancer (SNP x SNP interaction) (
24325914
)
Metabolite levels (
23823483
)
Neutrophil percentage of granulocytes (
27863252
)
Primary biliary cholangitis (
28425483
26394269
)
Primary biliary cirrhosis (
22961000
)
Systemic lupus erythematosus (
26316170
)
Systemic sclerosis (
29293537
)
Asthma (
31959851
)
Blood protein levels (
30072576
29875488
)
Blood protein levels in cardiovascular risk (
28369058
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Tuberculosis (
29036319
)
Urate levels (BMI interaction) (
25811787
)
Interacting Genes
108 interacting genes:
ACTN4
ADRA1B
AKT1
ATF3
BMX
BRCA1
CAMK2D
CAMK2G
CASP3
CASP7
CCR1
CCR5
CDC42
CREBBP
CSE1L
CSF2RB
CXCR4
DCTN1
DDB1
DDX6
DOT1L
DUSP2
DUSP3
E2F1
EGFR
EIF1AD
EIF2AK2
ELP2
EP300
FADD
FANCC
FGFR3
FGFR4
FLT1
FOS
FTH1
FYN
GFAP
GTF2I
HADH
HLA-B
HSF1
HSP90AB1
HSPA8
IFNAR2
IFNGR1
IL27RA
IL2RB
IL2RG
IRF1
IRF2
IRF9
JAK1
JAK2
JUN
KDR
KIT
KPNA1
KPNA6
LCK
LMO2
LZTR1
MAPK14
MAVS
MCM3
MCM5
MDK
MT-ND4L
NMI
NOMO1
NOMO2
OTUD4
PDGFRA
PDGFRB
PIAS1
PIK3CA
POR
PRKCD
PRMT1
PRMT3
PTK2
PTPN11
PTPN2
RAC1
RACK1
RELA
RPS6KA5
RXRA
SHANK1
SPTAN1
SPTB
SPTBN1
SRC
STAT2
STAT3
STAT4
STAT5A
STAT5B
SUMO4
SYK
TNFRSF1A
TNFRSF1B
TRADD
TYK2
UBE2I
VDR
XPO1
ZNF467
21 interacting genes:
ADAM17
BMX
CAV1
CD14
CSNK1A1
CSNK1A1L
FANCD2
HIVEP3
KRT18
LTA
PKN1
STAT1
TDP2
TNF
TRAF1
TRAF2
TRAF3
TRAIP
TRIM37
UBQLN1
ZNF420
Entrez ID
6772
7133
HPRD ID
02777
01862
Ensembl ID
ENSG00000115415
ENSG00000028137
Uniprot IDs
P42224
P20333
PDB IDs
1BF5
1YVL
2KA6
3WWT
1CA9
3ALQ
Enriched GO Terms of Interacting Partners
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