Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
MDK and LRP1
Data Source:
HPRD
(in vivo, in vitro)
MDK
LRP1
Description
midkine
LDL receptor related protein 1
Image
GO Annotations
Cellular Component
Extracellular Region
Collagen-containing Extracellular Matrix
Nucleus
Lysosomal Membrane
Early Endosome
Cytoskeleton
Plasma Membrane
Integral Component Of Plasma Membrane
Clathrin-coated Pit
Focal Adhesion
Membrane
Basolateral Plasma Membrane
Clathrin-coated Vesicle
Dendrite
Endocytic Vesicle Membrane
Insulin-responsive Compartment
Neuronal Cell Body
Receptor Complex
Axonal Growth Cone
Apical Part Of Cell
Plasma Membrane Protein Complex
Postsynaptic Golgi Apparatus
Molecular Function
Protein Binding
Growth Factor Activity
Heparin Binding
Chondroitin Sulfate Binding
Heparan Sulfate Binding
Amyloid-beta Binding
Protease Binding
RNA Binding
Low-density Lipoprotein Particle Receptor Activity
Scavenger Receptor Activity
Calcium Ion Binding
Protein Binding
Coreceptor Activity
Alpha-2 Macroglobulin Receptor Activity
Apolipoprotein Receptor Activity
Clathrin Heavy Chain Binding
Apolipoprotein Binding
Signaling Receptor Activity
Cargo Receptor Activity
Heparan Sulfate Proteoglycan Binding
Protein-containing Complex Binding
Lipoprotein Particle Receptor Binding
Biological Process
Leukocyte Chemotaxis Involved In Inflammatory Response
T Cell Activation Involved In Immune Response
Positive Regulation Of Leukocyte Chemotaxis
Cytoskeleton Organization
Negative Regulation Of Cell Adhesion
Signal Transduction
Notch Signaling Pathway
Nervous System Development
Response To Wounding
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Macrophage Chemotaxis
Positive Regulation Of Keratinocyte Proliferation
Positive Regulation Of Neuron Projection Development
Response To Auditory Stimulus
Cell Differentiation
Negative Regulation Of Ossification
Adrenal Gland Development
Positive Regulation Of Cell Migration
Regulation Of Chondrocyte Differentiation
Positive Regulation Of Interleukin-12 Production
Tissue Regeneration
Negative Regulation Of Neuron Apoptotic Process
Estrous Cycle
Positive Regulation Of T Cell Differentiation
Negative Regulation Of Regulatory T Cell Differentiation
Positive Regulation Of Cell Adhesion
Regulation Of Bone Remodeling
Oogenesis
Positive Regulation Of Oligodendrocyte Differentiation
Positive Regulation Of Inflammatory Response
Positive Regulation Of Cell Division
Positive Regulation Of Cartilage Development
Positive Regulation Of Smooth Muscle Cell Chemotaxis
Positive Regulation Of Neutrophil Chemotaxis
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Inflammatory Response To Wounding
Positive Regulation Of Inflammatory Response To Wounding
Glial Cell Projection Elongation
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Leukocyte Cell-cell Adhesion
Negative Regulation Of Epithelial Cell Apoptotic Process
Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Positive Regulation Of Blood Vessel Branching
Positive Regulation Of Vascular Endothelial Cell Proliferation
Positive Regulation Of Artery Morphogenesis
Positive Regulation Of Neural Precursor Cell Proliferation
Regulation Of Actin Cytoskeleton Reorganization
Positive Regulation Of Hepatocyte Proliferation
Positive Regulation Of Neutrophil Extravasation
Positive Regulation Of Neuron Migration
Retinoid Metabolic Process
Astrocyte Activation Involved In Immune Response
Lipid Metabolic Process
Receptor-mediated Endocytosis
Phagocytosis
Lysosomal Transport
Positive Regulation Of Cytosolic Calcium Ion Concentration
Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway
Aging
Cell Population Proliferation
Regulation Of Extracellular Matrix Disassembly
Positive Regulation Of Cholesterol Efflux
Positive Regulation Of Cell Death
Negative Regulation Of Neuron Projection Development
Negative Regulation Of Smooth Muscle Cell Migration
Cerebral Cortex Development
Negative Regulation Of Wnt Signaling Pathway
Receptor Internalization
Positive Regulation Of Protein Binding
Positive Regulation Of Lipid Transport
Regulation Of Cholesterol Transport
Regulation Of Phospholipase A2 Activity
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Aorta Morphogenesis
Lipoprotein Metabolic Process
Lipoprotein Transport
Apoptotic Cell Clearance
Negative Regulation Of Neuron Apoptotic Process
Cellular Lipid Catabolic Process
Transcytosis
Positive Regulation Of Endocytosis
Positive Regulation Of Axon Extension Involved In Regeneration
Positive Regulation Of Collateral Sprouting Of Injured Axon
Positive Regulation Of Phagocytosis
Negative Regulation Of Cytosolic Calcium Ion Concentration
Negative Regulation Of Focal Adhesion Assembly
Chemoattraction Of Axon
Positive Regulation Of ERK1 And ERK2 Cascade
Amyloid-beta Clearance
Amyloid-beta Clearance By Transcytosis
Amyloid-beta Clearance By Cellular Catabolic Process
Transport Across Blood-brain Barrier
Positive Regulation Of Schwann Cell Migration
Positive Regulation Of Amyloid-beta Clearance
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Cholesterol Import
Positive Regulation Of Transcytosis
Cellular Response To Amyloid-beta
Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Negative Regulation Of Metallopeptidase Activity
Positive Regulation Of Lysosomal Protein Catabolic Process
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways
NOTCH2 Activation and Transmission of Signal to the Nucleus
Scavenging of heme from plasma
Retinoid metabolism and transport
Drugs
Antihemophilic factor, human recombinant
Tenecteplase
Coagulation Factor IX (Recombinant)
Lanoteplase
Coagulation Factor IX Human
Lonoctocog alfa
Moroctocog alfa
Diseases
GWAS
Alzheimer's disease or fasting glucose levels (pleiotropy) (
30805717
)
Autism spectrum disorder or schizophrenia (
28540026
)
Feeling miserable (
29500382
)
Immunoglobulin A (
20694011
)
Schizophrenia (
28991256
29483656
30285260
)
Abdominal aortic aneurysm (
27899403
22055160
)
Adult asthma (
30787307
)
Asthma (
31959851
27182965
31619474
29273806
)
Asthma (adult onset) (
31036433
)
Asthma (childhood onset) (
31036433
)
Autism spectrum disorder or schizophrenia (
28540026
)
Bipolar disorder (
31043756
)
Body mass index (
28552196
)
Cervical artery dissection (
25420145
)
Coronary artery disease (
29212778
)
Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) (
28714975
)
HDL cholesterol (
24097068
20686565
)
HDL cholesterol levels (
28334899
)
Headache (
29397368
)
Height (
31562340
)
Itch intensity from mosquito bite (
28199695
)
Lung function (FEV1/FVC) (
30804560
)
Medication use (anilides) (
31015401
)
Medication use (antimigraine preparations) (
31015401
)
Migraine (
22683712
27182965
23793025
21666692
27322543
)
Migraine - clinic-based (
23793025
)
Migraine without aura (
23793025
27322543
)
Moyamoya disease (
29273593
)
Peak expiratory flow (
30804560
)
Pulmonary function (
21946350
)
Pulmonary function (smoking interaction) (
23284291
)
Pulse pressure (
30578418
)
Refractive error (
32231278
)
Schizophrenia (
25056061
29483656
)
Spontaneous coronary artery dissection (
32887874
32374345
)
Triglyceride levels (
28334899
)
Triglycerides (
24097068
25961943
20686565
)
Interacting Genes
32 interacting genes:
ALK
AP1M1
CDC42
FBXO7
HCK
JAK1
JAK2
JOSD2
LRP1
LRP2
LRP6
LRP8
MAPK6
MIEF2
NCL
NFU1
PBX3
PTPRZ1
RBFA
RPL18A
SDC1
SDC3
SDC4
SRPK2
STAT1
TCEA2
TGM1
TMED8
TSPAN1
UBQLN1
UBQLN2
UBQLN4
70 interacting genes:
A2M
ANAPC10
ANKS1B
APBA2
APBB1
APOE
APP
BACE1
BDNF
C3
C4BPA
CACNA1A
CALR
CANX
CAV1
CC2D1A
CCN2
CD82
CTSG
DAB1
DAB2
DLG4
EGFR
ELANE
F8
F9
FURIN
GIPC1
GTPBP1
GULP1
HNRNPDL
HSP90B1
ITGB1BP1
KAT5
LIPC
LPL
LRPAP1
LTF
MAPK8IP1
MAPK8IP2
MAPRE1
MDK
MMP13
MMP14
MMP15
MMP16
MMP17
MTDH
NGF
NOS1AP
NTF3
NTF4
PDGFB
PID1
PLAT
PLAUR
PRKACA
PTPN11
RIC8B
SCN3A
SERPINA1
SERPINE1
SHC1
SKIL
SNRNP70
SNX17
SRC
SYNJ2BP
THBS1
WNT3A
Entrez ID
4192
4035
HPRD ID
01200
00138
Ensembl ID
ENSG00000110492
ENSG00000123384
Uniprot IDs
P21741
Q07954
Q59FG2
PDB IDs
1MKC
1MKN
1CR8
1D2L
1J8E
2FYJ
2FYL
2KNX
2KNY
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?