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STAT1 and RXRA
Data Source:
BioGRID
(affinity chromatography technology, two hybrid)
STAT1
RXRA
Description
signal transducer and activator of transcription 1
retinoid X receptor alpha
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Axon
Dendrite
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Chromatin
Nucleus
Nucleoplasm
Mitochondrion
Receptor Complex
RNA Polymerase II Transcription Regulator Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Double-stranded DNA Binding
DNA-binding Transcription Factor Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Enzyme Binding
Histone Acetyltransferase Binding
Nuclear Hormone Receptor Binding
Histone Binding
Identical Protein Binding
Protein Homodimerization Activity
Ubiquitin-like Protein Ligase Binding
Cadherin Binding
Repressing Transcription Factor Binding
Promoter-specific Chromatin Binding
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Retinoic Acid Binding
Double-stranded DNA Binding
DNA-binding Transcription Factor Activity
Steroid Hormone Receptor Activity
Nuclear Receptor Activity
Protein Binding
Zinc Ion Binding
Nuclear Receptor Binding
Enzyme Binding
Peptide Binding
Identical Protein Binding
Vitamin D Receptor Binding
Sequence-specific DNA Binding
Retinoic Acid-responsive Element Binding
DNA Binding Domain Binding
LBD Domain Binding
Vitamin D Response Element Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Endothelial Cell Proliferation
Positive Regulation Of Mesenchymal Cell Proliferation
Positive Regulation Of Defense Response To Virus By Host
Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis
Defense Response
Positive Regulation Of Transcription Of Notch Receptor Target
Receptor Signaling Pathway Via JAK-STAT
Blood Circulation
Macrophage Derived Foam Cell Differentiation
Viral Process
Negative Regulation Of Angiogenesis
Cytokine-mediated Signaling Pathway
Positive Regulation Of Interferon-alpha Production
Tumor Necrosis Factor-mediated Signaling Pathway
Response To Cytokine
Response To Interferon-beta
Cellular Response To Interferon-beta
Interleukin-9-mediated Signaling Pathway
Interleukin-21-mediated Signaling Pathway
Regulation Of Cell Population Proliferation
Regulation Of Apoptotic Process
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Response To Peptide Hormone
Endothelial Cell Migration
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation By Virus Of Viral Protein Levels In Host Cell
Positive Regulation Of Smooth Muscle Cell Proliferation
Response To CAMP
Defense Response To Virus
Interferon-gamma-mediated Signaling Pathway
Regulation Of Interferon-gamma-mediated Signaling Pathway
Type I Interferon Signaling Pathway
Renal Tubule Development
Interleukin-6-mediated Signaling Pathway
Interleukin-27-mediated Signaling Pathway
Interleukin-35-mediated Signaling Pathway
Cellular Response To Interferon-gamma
Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development
Metanephric Mesenchymal Cell Differentiation
Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Cholesterol Metabolic Process
Bile Acid And Bile Salt Transport
Modulation By Virus Of Host Process
Regulation Of Lipid Metabolic Process
Cell Differentiation
Response To Retinoic Acid
Peroxisome Proliferator Activated Receptor Signaling Pathway
Steroid Hormone Mediated Signaling Pathway
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Retinoic Acid Receptor Signaling Pathway
Anatomical Structure Development
Pathways
Interleukin-6 signaling
ISG15 antiviral mechanism
Signaling by SCF-KIT
Signaling by cytosolic FGFR1 fusion mutants
Downstream signal transduction
Interleukin-4 and Interleukin-13 signaling
Interleukin-20 family signaling
Regulation of RUNX2 expression and activity
Interleukin-35 Signalling
Interleukin-9 signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH3 Intracellular Domain Regulates Transcription
Interleukin-27 signaling
Interleukin-21 signaling
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Growth hormone receptor signaling
RORA activates gene expression
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Recycling of bile acids and salts
Synthesis of bile acids and bile salts
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
PPARA activates gene expression
PPARA activates gene expression
Carnitine metabolism
Regulation of pyruvate dehydrogenase (PDH) complex
Endogenous sterols
Transcriptional activation of mitochondrial biogenesis
Activation of gene expression by SREBF (SREBP)
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
Regulation of lipid metabolism by PPARalpha
Circadian Clock
SUMOylation of intracellular receptors
Signaling by Retinoic Acid
Activation of anterior HOX genes in hindbrain development during early embryogenesis
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose
Transcriptional regulation of granulopoiesis
Transcriptional regulation of granulopoiesis
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis
Drugs
alpha-Linolenic acid
Adapalene
Bexarotene
Rosiglitazone
Acitretin
Alitretinoin
Etodolac
Tretinoin
Etretinate
Bezafibrate
Alfacalcidol
Phthalic Acid
Doconexent
Oleic Acid
Arachidonic Acid
EVT-101
3,20-Pregnanedione
2-chloro-5-nitro-N-phenylbenzamide
1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE
2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID
Tributyltin
Diseases
Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
GWAS
Birth weight (
31043758
)
Height (
31562340
)
Inflammatory bowel disease (
23128233
)
JT interval (sulfonylurea treatment interaction) (
27958378
)
Limited cutaneous systemic scleroderma (
29293537
)
Lung cancer (SNP x SNP interaction) (
24325914
)
Metabolite levels (
23823483
)
Neutrophil percentage of granulocytes (
27863252
)
Primary biliary cholangitis (
28425483
26394269
)
Primary biliary cirrhosis (
22961000
)
Systemic lupus erythematosus (
26316170
)
Systemic sclerosis (
29293537
)
Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) (
23648065
)
Blood pressure (
24954895
)
Central corneal thickness (
28171582
22814818
31798171
23493294
29760442
30894546
)
Corneal structure (
23291589
)
Crohn's disease (need for surgery) (
23665963
)
Intelligence (
22449649
)
Intraocular pressure (
29617998
)
Refractive error (
32231278
)
Waist-to-hip ratio adjusted for BMI x sex interaction (
26426971
)
Interacting Genes
108 interacting genes:
ACTN4
ADRA1B
AKT1
ATF3
BMX
BRCA1
CAMK2D
CAMK2G
CASP3
CASP7
CCR1
CCR5
CDC42
CREBBP
CSE1L
CSF2RB
CXCR4
DCTN1
DDB1
DDX6
DOT1L
DUSP2
DUSP3
E2F1
EGFR
EIF1AD
EIF2AK2
ELP2
EP300
FADD
FANCC
FGFR3
FGFR4
FLT1
FOS
FTH1
FYN
GFAP
GTF2I
HADH
HLA-B
HSF1
HSP90AB1
HSPA8
IFNAR2
IFNGR1
IL27RA
IL2RB
IL2RG
IRF1
IRF2
IRF9
JAK1
JAK2
JUN
KDR
KIT
KPNA1
KPNA6
LCK
LMO2
LZTR1
MAPK14
MAVS
MCM3
MCM5
MDK
MT-ND4L
NMI
NOMO1
NOMO2
OTUD4
PDGFRA
PDGFRB
PIAS1
PIK3CA
POR
PRKCD
PRMT1
PRMT3
PTK2
PTPN11
PTPN2
RAC1
RACK1
RELA
RPS6KA5
RXRA
SHANK1
SPTAN1
SPTB
SPTBN1
SRC
STAT2
STAT3
STAT4
STAT5A
STAT5B
SUMO4
SYK
TNFRSF1A
TNFRSF1B
TRADD
TYK2
UBE2I
VDR
XPO1
ZNF467
118 interacting genes:
ACVR1
ACVR1B
ALOX15B
ARID5A
ARNTL
BCL3
BRD8
CASP2
CHD9
CLOCK
CNOT1
COPS2
CSNK2B
CTCF
CTNNB1
CTSL
DNMT3L
DNTTIP2
EDF1
ESR1
ESRRA
FUS
GADD45A
GADD45G
GATA2
GK
GRIP1
GSK3B
HDAC3
HDAC4
HMGA1
IGFBP3
ITGB3BP
JAZF1
JMJD1C
KIF1A
KLF5
MAPK1
MAPK3
MAPK7
MECR
MED1
MED24
MED25
MPG
MYOD1
NCOA1
NCOA2
NCOA3
NCOA4
NCOA6
NCOR1
NCOR2
NFKB1
NFKBIB
NPAS2
NR0B2
NR1H2
NR1H3
NR1H4
NR1I2
NR1I3
NR2E3
NR2F1
NR2F6
NR3C2
NR4A1
NR4A2
NRBF2
NRIP1
NSD1
PARP1
PLK1
PML
POU2F1
POU2F2
PPARA
PPARD
PPARG
PPARGC1A
PRKD2
PRMT2
PSMC3IP
PSMC5
RAD54L2
RARA
RARB
RARG
RELA
RNF8
ROBO4
RPS6KA6
SMAD2
SMARCB1
SMARCD3
SMN1
SNW1
SP1
SRC
SRF
STAT1
TADA3
TAF11
TAF1B
TBP
TDG
THRA
THRB
TK1
TMPRSS3
TRIM24
TRIP10
TRIP4
UBE2I
UBQLN4
VDR
ZBTB16
ZNHIT3
Entrez ID
6772
6256
HPRD ID
02777
01577
Ensembl ID
ENSG00000115415
ENSG00000186350
Uniprot IDs
P42224
A0A5F9ZHH6
F1D8Q5
P19793
Q6P3U7
PDB IDs
1BF5
1YVL
2KA6
3WWT
1BY4
1DSZ
1FBY
1FM6
1FM9
1G1U
1G5Y
1K74
1MV9
1MVC
1MZN
1R0N
1RDT
1RXR
1XLS
1XV9
1XVP
1YNW
2ACL
2NLL
2P1T
2P1U
2P1V
2ZXZ
2ZY0
3DZU
3DZY
3E00
3E94
3FAL
3FC6
3FUG
3H0A
3KWY
3NSP
3NSQ
3OAP
3OZJ
3PCU
3R29
3R2A
3R5M
3UVV
4CN2
4CN3
4CN5
4CN7
4J5W
4J5X
4K4J
4K6I
4M8E
4M8H
4N5G
4N8R
4NQA
4OC7
4POH
4POJ
4PP3
4PP5
4RFW
4RMC
4RMD
4RME
4ZO1
4ZSH
5EC9
5JI0
5LYQ
5MJ5
5MK4
5MKJ
5MKU
5MMW
5TBP
5UAN
5Z12
5ZQU
6A5Y
6A5Z
6A60
6FBQ
6FBR
6HN6
6JNO
6JNR
6L6K
6SJM
6STI
6XWG
6XWH
7A77
Enriched GO Terms of Interacting Partners
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