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STAT1 and DDX6
Data Source:
BioGRID
(pull down)
STAT1
DDX6
Description
signal transducer and activator of transcription 1
DEAD-box helicase 6
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Axon
Dendrite
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Heterochromatin
P-body
Outer Dense Fiber
Nucleus
Nucleolus
Cytoplasm
Mitochondrion
Cytosol
Adherens Junction
Cytoplasmic Stress Granule
Membrane
RISC Complex
Chromatoid Body
Cytoplasmic Ribonucleoprotein Granule
Perinuclear Region Of Cytoplasm
Concave Side Of Sperm Head
Sperm Annulus
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Double-stranded DNA Binding
DNA-binding Transcription Factor Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Enzyme Binding
Histone Acetyltransferase Binding
Nuclear Hormone Receptor Binding
Histone Binding
Identical Protein Binding
Protein Homodimerization Activity
Ubiquitin-like Protein Ligase Binding
Cadherin Binding
Repressing Transcription Factor Binding
Promoter-specific Chromatin Binding
RNA Binding
RNA Helicase Activity
MRNA Binding
Helicase Activity
Protein Binding
ATP Binding
Protein Domain Specific Binding
Cadherin Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Endothelial Cell Proliferation
Positive Regulation Of Mesenchymal Cell Proliferation
Positive Regulation Of Defense Response To Virus By Host
Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis
Defense Response
Positive Regulation Of Transcription Of Notch Receptor Target
Receptor Signaling Pathway Via JAK-STAT
Blood Circulation
Macrophage Derived Foam Cell Differentiation
Viral Process
Negative Regulation Of Angiogenesis
Cytokine-mediated Signaling Pathway
Positive Regulation Of Interferon-alpha Production
Tumor Necrosis Factor-mediated Signaling Pathway
Response To Cytokine
Response To Interferon-beta
Cellular Response To Interferon-beta
Interleukin-9-mediated Signaling Pathway
Interleukin-21-mediated Signaling Pathway
Regulation Of Cell Population Proliferation
Regulation Of Apoptotic Process
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Response To Peptide Hormone
Endothelial Cell Migration
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation By Virus Of Viral Protein Levels In Host Cell
Positive Regulation Of Smooth Muscle Cell Proliferation
Response To CAMP
Defense Response To Virus
Interferon-gamma-mediated Signaling Pathway
Regulation Of Interferon-gamma-mediated Signaling Pathway
Type I Interferon Signaling Pathway
Renal Tubule Development
Interleukin-6-mediated Signaling Pathway
Interleukin-27-mediated Signaling Pathway
Interleukin-35-mediated Signaling Pathway
Cellular Response To Interferon-gamma
Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development
Metanephric Mesenchymal Cell Differentiation
Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation
Negative Regulation Of Translation
Viral RNA Genome Packaging
Stem Cell Population Maintenance
P-body Assembly
Stress Granule Assembly
Exonucleolytic Catabolism Of Deadenylated MRNA
Negative Regulation Of Neuron Differentiation
Spermatid Differentiation
Positive Regulation Of MiRNA Mediated Inhibition Of Translation
Pathways
Interleukin-6 signaling
ISG15 antiviral mechanism
Signaling by SCF-KIT
Signaling by cytosolic FGFR1 fusion mutants
Downstream signal transduction
Interleukin-4 and Interleukin-13 signaling
Interleukin-20 family signaling
Regulation of RUNX2 expression and activity
Interleukin-35 Signalling
Interleukin-9 signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH3 Intracellular Domain Regulates Transcription
Interleukin-27 signaling
Interleukin-21 signaling
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Growth hormone receptor signaling
mRNA decay by 5' to 3' exoribonuclease
Drugs
D-tartaric acid
Diseases
Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
GWAS
Birth weight (
31043758
)
Height (
31562340
)
Inflammatory bowel disease (
23128233
)
JT interval (sulfonylurea treatment interaction) (
27958378
)
Limited cutaneous systemic scleroderma (
29293537
)
Lung cancer (SNP x SNP interaction) (
24325914
)
Metabolite levels (
23823483
)
Neutrophil percentage of granulocytes (
27863252
)
Primary biliary cholangitis (
28425483
26394269
)
Primary biliary cirrhosis (
22961000
)
Systemic lupus erythematosus (
26316170
)
Systemic sclerosis (
29293537
)
Allergic disease (asthma, hay fever and/or eczema) (age of onset) (
32603359
)
Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) (
32603359
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Allergic rhinitis (
30013184
)
Allergy (
27182965
)
Asthma (
31959851
30929738
31619474
)
Asthma (age of onset) (
31036433
)
Asthma (childhood onset) (
31036433
30929738
)
Asthma onset (childhood vs adult) (
30929738
)
Autoimmune traits (pleiotropy) (
30572963
)
Blood protein levels (
30072576
)
Celiac disease (
22057235
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Celiac disease or Rheumatoid arthritis (
21383967
)
Diffuse cutaneous systemic sclerosis (
24387989
)
Height (
25429064
)
Hip minimal joint space width (
27701424
)
Monocyte percentage of white cells (
32888494
)
Multiple sclerosis (
31604244
)
Non-albumin protein levels (
29403010
)
Primary biliary cholangitis (
28425483
)
Primary biliary cirrhosis (
22961000
)
Refractive error (
32231278
)
Rheumatoid arthritis (
23143596
)
Rheumatoid arthritis (ACPA-positive) (
23143596
24532676
)
Systemic lupus erythematosus (
28714469
19838195
)
Systemic sclerosis (
24387989
31672989
)
Vitiligo (
22951725
)
Interacting Genes
108 interacting genes:
ACTN4
ADRA1B
AKT1
ATF3
BMX
BRCA1
CAMK2D
CAMK2G
CASP3
CASP7
CCR1
CCR5
CDC42
CREBBP
CSE1L
CSF2RB
CXCR4
DCTN1
DDB1
DDX6
DOT1L
DUSP2
DUSP3
E2F1
EGFR
EIF1AD
EIF2AK2
ELP2
EP300
FADD
FANCC
FGFR3
FGFR4
FLT1
FOS
FTH1
FYN
GFAP
GTF2I
HADH
HLA-B
HSF1
HSP90AB1
HSPA8
IFNAR2
IFNGR1
IL27RA
IL2RB
IL2RG
IRF1
IRF2
IRF9
JAK1
JAK2
JUN
KDR
KIT
KPNA1
KPNA6
LCK
LMO2
LZTR1
MAPK14
MAVS
MCM3
MCM5
MDK
MT-ND4L
NMI
NOMO1
NOMO2
OTUD4
PDGFRA
PDGFRB
PIAS1
PIK3CA
POR
PRKCD
PRMT1
PRMT3
PTK2
PTPN11
PTPN2
RAC1
RACK1
RELA
RPS6KA5
RXRA
SHANK1
SPTAN1
SPTB
SPTBN1
SRC
STAT2
STAT3
STAT4
STAT5A
STAT5B
SUMO4
SYK
TNFRSF1A
TNFRSF1B
TRADD
TYK2
UBE2I
VDR
XPO1
ZNF467
77 interacting genes:
BEGAIN
BEND7
BHLHB9
BIRC7
CALCOCO2
CCDC136
CCDC14
CEP70
CEP76
CNKSR3
CNOT1
DDX17
DES
DISC1
DNAAF11
EDC3
EFHC2
ENTR1
FCHO1
GIGYF1
GOLGA2
HOOK2
IK
IKZF1
INKA1
JAKMIP1
JUP
KLC4
KRT34
KRT40
KRTAP10-3
KRTAP10-8
LZTS1
MAGED1
MESD
MTUS2
NAB2
NONO
PAK5
PDLIM7
PICK1
PNMA5
POU6F2
PRDM16
PRPH
RAPGEF3
RBM11
RBM14
REL
RO60
RUNDC3A
SCYL1
SHMT1
SIPA1L2
SLAIN1
SORBS3
SPATA6
SRPK2
STAT1
TCF12
TCF4
TLE5
TP53BP2
TRAF2
TRIM27
TRIM37
TRIM54
U2AF2
USH1G
VPS52
ZBTB10
ZBTB14
ZBTB43
ZBTB8A
ZC2HC1C
ZNF24
ZRANB1
Entrez ID
6772
1656
HPRD ID
02777
02638
Ensembl ID
ENSG00000115415
ENSG00000110367
Uniprot IDs
P42224
B2R858
P26196
PDB IDs
1BF5
1YVL
2KA6
3WWT
1VEC
2WAX
2WAY
4CRW
4CT4
4CT5
5ANR
6F9S
6S8S
Enriched GO Terms of Interacting Partners
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