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MDK and TSPAN1
Data Source:
HPRD
(two hybrid, in vivo, in vitro)
MDK
TSPAN1
Description
midkine
tetraspanin 1
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Collagen-containing Extracellular Matrix
Nucleoplasm
Cytoplasm
Lysosomal Membrane
Plasma Membrane
Integral Component Of Plasma Membrane
Membrane
Cell Junction
Vesicle
Intracellular Membrane-bounded Organelle
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Molecular Function
Protein Binding
Growth Factor Activity
Heparin Binding
Chondroitin Sulfate Binding
Heparan Sulfate Binding
Protein Binding
Biological Process
Leukocyte Chemotaxis Involved In Inflammatory Response
T Cell Activation Involved In Immune Response
Positive Regulation Of Leukocyte Chemotaxis
Cytoskeleton Organization
Negative Regulation Of Cell Adhesion
Signal Transduction
Notch Signaling Pathway
Nervous System Development
Response To Wounding
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Macrophage Chemotaxis
Positive Regulation Of Keratinocyte Proliferation
Positive Regulation Of Neuron Projection Development
Response To Auditory Stimulus
Cell Differentiation
Negative Regulation Of Ossification
Adrenal Gland Development
Positive Regulation Of Cell Migration
Regulation Of Chondrocyte Differentiation
Positive Regulation Of Interleukin-12 Production
Tissue Regeneration
Negative Regulation Of Neuron Apoptotic Process
Estrous Cycle
Positive Regulation Of T Cell Differentiation
Negative Regulation Of Regulatory T Cell Differentiation
Positive Regulation Of Cell Adhesion
Regulation Of Bone Remodeling
Oogenesis
Positive Regulation Of Oligodendrocyte Differentiation
Positive Regulation Of Inflammatory Response
Positive Regulation Of Cell Division
Positive Regulation Of Cartilage Development
Positive Regulation Of Smooth Muscle Cell Chemotaxis
Positive Regulation Of Neutrophil Chemotaxis
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Inflammatory Response To Wounding
Positive Regulation Of Inflammatory Response To Wounding
Glial Cell Projection Elongation
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Leukocyte Cell-cell Adhesion
Negative Regulation Of Epithelial Cell Apoptotic Process
Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Positive Regulation Of Blood Vessel Branching
Positive Regulation Of Vascular Endothelial Cell Proliferation
Positive Regulation Of Artery Morphogenesis
Positive Regulation Of Neural Precursor Cell Proliferation
Regulation Of Actin Cytoskeleton Reorganization
Positive Regulation Of Hepatocyte Proliferation
Positive Regulation Of Neutrophil Extravasation
Positive Regulation Of Neuron Migration
Protein Stabilization
Pathways
NOTCH2 Activation and Transmission of Signal to the Nucleus
Drugs
Diseases
GWAS
Alzheimer's disease or fasting glucose levels (pleiotropy) (
30805717
)
Autism spectrum disorder or schizophrenia (
28540026
)
Feeling miserable (
29500382
)
Immunoglobulin A (
20694011
)
Schizophrenia (
28991256
29483656
30285260
)
Body mass index (
26426971
)
Interacting Genes
32 interacting genes:
ALK
AP1M1
CDC42
FBXO7
HCK
JAK1
JAK2
JOSD2
LRP1
LRP2
LRP6
LRP8
MAPK6
MIEF2
NCL
NFU1
PBX3
PTPRZ1
RBFA
RPL18A
SDC1
SDC3
SDC4
SRPK2
STAT1
TCEA2
TGM1
TMED8
TSPAN1
UBQLN1
UBQLN2
UBQLN4
4 interacting genes:
MDK
NFKBIB
TFAM
TMEM80
Entrez ID
4192
10103
HPRD ID
01200
18232
Ensembl ID
ENSG00000110492
ENSG00000117472
Uniprot IDs
P21741
O60635
PDB IDs
1MKC
1MKN
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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