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SMAD1 and PUM1
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
SMAD1
PUM1
Description
SMAD family member 1
pumilio RNA binding family member 1
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nuclear Inner Membrane
Nucleoplasm
Cytoplasm
Cytosol
Integral Component Of Membrane
Protein-containing Complex
SMAD Protein Complex
Heteromeric SMAD Protein Complex
P-body
Nucleoplasm
Cytoplasm
Cytosol
Cytoplasmic Stress Granule
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
DEAD/H-box RNA Helicase Binding
Protein Kinase Binding
Identical Protein Binding
Metal Ion Binding
Co-SMAD Binding
I-SMAD Binding
Primary MiRNA Binding
RNA Binding
MRNA Binding
MRNA 3'-UTR Binding
Protein Binding
MiRNA Binding
Biological Process
MAPK Cascade
Ureteric Bud Development
Mesodermal Cell Fate Commitment
Osteoblast Fate Commitment
Regulation Of Transcription By RNA Polymerase II
Protein Phosphorylation
Inflammatory Response
Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
SMAD Protein Complex Assembly
Gamete Generation
Negative Regulation Of Cell Population Proliferation
Anatomical Structure Morphogenesis
Embryonic Pattern Specification
Positive Regulation Of Gene Expression
Protein Deubiquitination
Cell Differentiation
BMP Signaling Pathway
Midbrain Development
Hindbrain Development
Primary MiRNA Processing
Homeostatic Process
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Cartilage Development
Cardiac Muscle Cell Proliferation
Bone Development
SMAD Protein Signal Transduction
Positive Regulation Of Cartilage Development
Cellular Response To Organic Cyclic Compound
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Sprouting Angiogenesis
Spermatogenesis
Adult Locomotory Behavior
Posttranscriptional Regulation Of Gene Expression
Posttranscriptional Gene Silencing
Production Of MiRNAs Involved In Gene Silencing By MiRNA
Regulation Of MRNA Stability
Stem Cell Differentiation
Regulation Of Cell Cycle
Regulation Of Chromosome Segregation
Regulation Of Gene Silencing By MiRNA
MRNA Destabilization
Positive Regulation Of RIG-I Signaling Pathway
Positive Regulation Of Gene Silencing By MiRNA
Pathways
Signaling by BMP
Ub-specific processing proteases
RUNX2 regulates bone development
Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS
HDL cholesterol levels (
32203549
)
Hemoglobin (
32888494
)
Lung function (FEV1) (
30061609
)
Malaria (
31844061
)
Midgestational cytokine/chemokine levels (maternal genetic effect) (
30134952
)
Panic disorder (
31712720
)
Red cell distribution width (
32888494
)
Response to cognitive-behavioural therapy in anxiety disorder (
26989097
)
Interacting Genes
160 interacting genes:
ACVR1
ACVRL1
AKR1B1
ANKRD27
AP2A2
APC
APP
AR
ARHGEF6
ARL4D
AXIN2
BMPR1A
BTBD2
BTG2
BUB1
CAMSAP1
CCND1
CDK7
CDK9
CHMP3
CILK1
COL4A1
CTNNA1
DACH1
DLC1
DNMT3L
DVL1
ECSIT
EIF2AK4
ELP3
EP300
EPN2
ERBB2
ERBIN
EWSR1
FBXL12
FBXO30
FBXW7
FHL5
FOXG1
FRZB
GDF6
GLI3
GMEB1
GSC
HBP1
HIPK2
HOXA13
HOXA5
HOXC8
HOXD13
ING2
INPP4A
IRF2BP1
KAT2B
KMT2D
LEF1
LEMD3
LMNA
MAP2K3
MAPK1
MAST4
MBD1
MECOM
MED6
MEN1
MGA
MLH1
MLH3
MRTFB
MSH2
MUTYH
NAT9
NEDD4
NEDD9
NEUROG1
NKX3-2
NOTCH2
NRAS
OAZ1
OAZ3
PAK1
PARD3
PDGFRL
PIAS1
PIAS4
PIGQ
PLEKHB1
PREB
PSMB4
PSMD1
PSMD11
PTPN12
PUM1
RAB2B
RAB30
RAB34
RAB38
RAB3B
RAB6B
RAC2
RAN
RAP2A
RASD2
RASL12
RFX1
RHEBL1
RHOG
RPS27A
SF3B1
SKI
SKIL
SMAD2
SMAD3
SMAD4
SMAD5
SMAD6
SMARCE1
SMURF1
SMURF2
SNIP1
SNRNP70
SOX5
SQSTM1
SS18L1
STARD13
STK11
STUB1
SUV39H1
TCF20
TET2
TGFBR1
TLR2
TNNT1
TOB1
TRIP6
TTF1
TTF2
UBA52
UBC
UBE2Z
UBXN1
USP45
VEPH1
WDR77
XPC
XPO1
YAP1
YY1
ZBTB44
ZDHHC3
ZEB2
ZNF251
ZNF423
ZNF510
ZNF512B
ZNF521
ZNF76
ZNF8
ZSCAN4
47 interacting genes:
ATXN1
EIF5
MIR1-1
MIR1-2
MIR106A
MIR106B
MIR107
MIR128-2
MIR138-1
MIR138-2
MIR140
MIR143
MIR145
MIR15B
MIR17
MIR18B
MIR199A1
MIR199A2
MIR19B1
MIR19B2
MIR200A
MIR200B
MIR206
MIR20A
MIR20B
MIR21
MIR214
MIR25
MIR29A
MIR29C
MIR34A
MIR7-1
MIR9-3
MIR92A2
MIR93
MIR98
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7D
MIRLET7E
MIRLET7F1
MIRLET7F2
MIRLET7G
MIRLET7I
PRR12
SMAD1
Entrez ID
4086
9698
HPRD ID
03356
06230
Ensembl ID
ENSG00000170365
ENSG00000134644
Uniprot IDs
Q15797
Q14671
PDB IDs
1KHU
2LAW
2LAX
2LAY
2LAZ
2LB0
2LB1
3Q47
3Q4A
5ZOK
1IB2
1M8W
1M8X
1M8Y
1M8Z
2YJY
3BSB
3BSX
3Q0L
3Q0M
3Q0N
3Q0O
3Q0P
5YKH
5YKI
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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