PUM1 and MIR21

Data Source:
BioGRID (unspecified method)

		PUM1	MIR21
Description		pumilio RNA binding family member 1	microRNA 21
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleoplasm Cytoplasm Cytosol Cytoplasmic Stress Granule	Extracellular Space Cytoplasm Extracellular Exosome Extracellular Vesicle
	Molecular Function	RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding MiRNA Binding	MRNA 3'-UTR Binding MRNA Binding Involved In Posttranscriptional Gene Silencing
	Biological Process	Spermatogenesis Adult Locomotory Behavior Posttranscriptional Regulation Of Gene Expression Posttranscriptional Gene Silencing Production Of MiRNAs Involved In Gene Silencing By MiRNA Regulation Of MRNA Stability Stem Cell Differentiation Regulation Of Cell Cycle Regulation Of Chromosome Segregation Regulation Of Gene Silencing By MiRNA MRNA Destabilization Positive Regulation Of RIG-I Signaling Pathway Positive Regulation Of Gene Silencing By MiRNA	Blood Vessel Development Positive Regulation Of Cytokine Production Positive Regulation Of Protein Phosphorylation Negative Regulation Of Endothelial Cell Proliferation Negative Regulation Of Cytokine-mediated Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Embryo Implantation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Cell Shape Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Keratinocyte Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Angiogenesis Regulation Of Cell Migration Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration BMP Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell Projection Organization Negative Regulation Of NF-kappaB Transcription Factor Activity Activation Of Protein Kinase B Activity Negative Regulation Of Type I Interferon Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-21 Production Collagen Metabolic Process Negative Regulation Of GTPase Activity Negative Regulation Of Smooth Muscle Cell Apoptotic Process Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation Phenotypic Switching Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of MAPK Cascade Negative Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Innate Immune Response Positive Regulation Of Inflammatory Response Negative Regulation Of Stress Fiber Assembly Regulation Of Protein Kinase B Signaling Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Type I Interferon-mediated Signaling Pathway Epithelial To Mesenchymal Transition Involved In Cardiac Fibroblast Development Negative Regulation Of Cartilage Development Endothelial Tube Morphogenesis Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Virus Positive Regulation Of Inflammatory Response To Wounding Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Cellular Response To Hypoxia Negative Regulation Of Arginine Catabolic Process Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Negative Regulation Of Superoxide Dismutase Activity Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Negative Regulation Of Chondrocyte Proliferation Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Potassium Ion Export Across Plasma Membrane Cellular Response To Resveratrol Positive Regulation Of Metalloendopeptidase Activity Positive Regulation Of Vascular Associated Smooth Muscle Contraction Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Replicative Senescence Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Myofibroblast Differentiation Negative Regulation Of Hydrogen Sulfide Biosynthetic Process Negative Regulation Of Aortic Smooth Muscle Cell Differentiation Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Vascular Endothelial Cell Proliferation Negative Regulation Of Endothelial Tube Morphogenesis Retinal Cell Apoptotic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 17 Cell Differentiation Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Interleukin-1-mediated Signaling Pathway
Pathways		Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS			Monocyte count ( 29403010)
Interacting Genes		47 interacting genes: ATXN1 EIF5 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR143 MIR145 MIR15B MIR17 MIR18B MIR199A1 MIR199A2 MIR19B1 MIR19B2 MIR200A MIR200B MIR206 MIR20A MIR20B MIR21 MIR214 MIR25 MIR29A MIR29C MIR34A MIR7-1 MIR9-3 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PRR12 SMAD1	95 interacting genes: AIMP2 APOBEC3B ATXN2L C1QBP CELF1 CELF2 CPSF1 CSTF3 DARS1 DDX1 DDX21 DDX3X DHX36 DHX37 EDC4 EIF2AK2 EPRS1 ERAL1 ESRP1 FAM98A FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LRPPRC MARS1 MATR3 MSI2 MYEF2 NOL6 NONO NUDT16L1 NUFIP2 PATL1 PDCD11 PGAM5 PTBP1 PTBP3 PTCD3 PUF60 PUM1 PURA QARS1 RARS1 RBFOX2 RBM10 RBM14 RBM17 RBM4 RBM4B RTCA RTCB SF3B1 SF3B2 SF3B3 SF3B4 SF3B5 SFPQ SPOUT1 SUGP2 SYMPK SYNCRIP TAF15 TENT2 TRA2A TRA2B TRIM25 U2SURP UPF1 USP36 UTP20 YBX1 YBX2 YBX3 ZFR ZNF106
Entrez ID		9698	406991
HPRD ID		06230
Ensembl ID		ENSG00000134644	ENSG00000284190
Uniprot IDs		Q14671
PDB IDs		1IB2 1M8W 1M8X 1M8Y 1M8Z 2YJY 3BSB 3BSX 3Q0L 3Q0M 3Q0N 3Q0O 3Q0P 5YKH 5YKI
Enriched GO Terms of Interacting Partners?
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