PUM1 and EIF5

Data Source:
BioGRID (two hybrid)

		PUM1	EIF5
Description		pumilio RNA binding family member 1	eukaryotic translation initiation factor 5
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GO Annotations	Cellular Component	P-body Nucleoplasm Cytoplasm Cytosol Cytoplasmic Stress Granule	Nucleus Cytoplasm Cytosol Plasma Membrane
	Molecular Function	RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding MiRNA Binding	RNA Binding Translation Initiation Factor Activity GDP-dissociation Inhibitor Activity Protein Binding GTP Binding Cadherin Binding Eukaryotic Initiation Factor EIF2 Binding
	Biological Process	Spermatogenesis Adult Locomotory Behavior Posttranscriptional Regulation Of Gene Expression Posttranscriptional Gene Silencing Production Of MiRNAs Involved In Gene Silencing By MiRNA Regulation Of MRNA Stability Stem Cell Differentiation Regulation Of Cell Cycle Regulation Of Chromosome Segregation Regulation Of Gene Silencing By MiRNA MRNA Destabilization Positive Regulation Of RIG-I Signaling Pathway Positive Regulation Of Gene Silencing By MiRNA	Formation Of Translation Preinitiation Complex Formation Of Cytoplasmic Translation Initiation Complex Regulation Of Translational Initiation Activation Of GTPase Activity
Pathways		Golgi Associated Vesicle Biogenesis	Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Monocyte count ( 29403010) Number of sexual partners ( 30643258) Red blood cell traits ( 23222517)
Interacting Genes		47 interacting genes: ATXN1 EIF5 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR143 MIR145 MIR15B MIR17 MIR18B MIR199A1 MIR199A2 MIR19B1 MIR19B2 MIR200A MIR200B MIR206 MIR20A MIR20B MIR21 MIR214 MIR25 MIR29A MIR29C MIR34A MIR7-1 MIR9-3 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PRR12 SMAD1	16 interacting genes: APP CDC42 CSNK2A1 CSNK2B DUSP12 EIF1AX EIF1AY EIF2S2 EIF3D EIF3G EIF4G1 EIF4G2 HSPB1 NCBP2 NRGN PUM1
Entrez ID		9698	1983
HPRD ID		06230	03417
Ensembl ID		ENSG00000134644	ENSG00000100664
Uniprot IDs		Q14671	A0A024R6Q1 P55010
PDB IDs		1IB2 1M8W 1M8X 1M8Y 1M8Z 2YJY 3BSB 3BSX 3Q0L 3Q0M 3Q0N 3Q0O 3Q0P 5YKH 5YKI	2E9H 2G2K 2IU1
Enriched GO Terms of Interacting Partners?
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