SMAD1 and MSH2

Data Source:
BioGRID (two hybrid)

		SMAD1	MSH2
Description		SMAD family member 1	mutS homolog 2
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nuclear Inner Membrane Nucleoplasm Cytoplasm Cytosol Integral Component Of Membrane Protein-containing Complex SMAD Protein Complex Heteromeric SMAD Protein Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm Membrane Mismatch Repair Complex MutSalpha Complex MutSbeta Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding DEAD/H-box RNA Helicase Binding Protein Kinase Binding Identical Protein Binding Metal Ion Binding Co-SMAD Binding I-SMAD Binding Primary MiRNA Binding	Magnesium Ion Binding Four-way Junction DNA Binding Double-strand/single-strand DNA Junction Binding DNA Binding Chromatin Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding Protein C-terminus Binding DNA-dependent ATPase Activity ATPase Activity Centromeric DNA Binding Enzyme Binding Protein Kinase Binding Mismatched DNA Binding Guanine/thymine Mispair Binding Dinucleotide Insertion Or Deletion Binding Single Guanine Insertion Binding Single Thymine Insertion Binding Dinucleotide Repeat Insertion Binding Oxidized Purine DNA Binding MutLalpha Complex Binding Protein Homodimerization Activity ADP Binding
	Biological Process	MAPK Cascade Ureteric Bud Development Mesodermal Cell Fate Commitment Osteoblast Fate Commitment Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Inflammatory Response Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Complex Assembly Gamete Generation Negative Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Embryonic Pattern Specification Positive Regulation Of Gene Expression Protein Deubiquitination Cell Differentiation BMP Signaling Pathway Midbrain Development Hindbrain Development Primary MiRNA Processing Homeostatic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cartilage Development Cardiac Muscle Cell Proliferation Bone Development SMAD Protein Signal Transduction Positive Regulation Of Cartilage Development Cellular Response To Organic Cyclic Compound Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Sprouting Angiogenesis	In Utero Embryonic Development Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Oxidative Phosphorylation DNA Repair Mismatch Repair Postreplication Repair Double-strand Break Repair DNA Recombination Cell Cycle Arrest Germ Cell Development Determination Of Adult Lifespan Male Gonad Development Response To X-ray Response To UV-B Somatic Hypermutation Of Immunoglobulin Genes Somatic Recombination Of Immunoglobulin Gene Segments B Cell Mediated Immunity B Cell Differentiation Intra-S DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Neuron Apoptotic Process Maintenance Of DNA Repeat Elements Isotype Switching Negative Regulation Of DNA Recombination Positive Regulation Of Isotype Switching To IgA Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Helicase Activity Protein Localization To Chromatin
Pathways		Signaling by BMP Ub-specific processing proteases RUNX2 regulates bone development	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MSH3 Defective Mismatch Repair Associated With MSH2 Defective Mismatch Repair Associated With MSH6 TP53 Regulates Transcription of DNA Repair Genes
Drugs
Diseases			Colorectal cancer Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome Ovarian cancer
GWAS		HDL cholesterol levels ( 32203549) Hemoglobin ( 32888494) Lung function (FEV1) ( 30061609) Malaria ( 31844061) Midgestational cytokine/chemokine levels (maternal genetic effect) ( 30134952) Panic disorder ( 31712720) Red cell distribution width ( 32888494) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097)	Electroencephalogram traits ( 25387704) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		160 interacting genes: ACVR1 ACVRL1 AKR1B1 ANKRD27 AP2A2 APC APP AR ARHGEF6 ARL4D AXIN2 BMPR1A BTBD2 BTG2 BUB1 CAMSAP1 CCND1 CDK7 CDK9 CHMP3 CILK1 COL4A1 CTNNA1 DACH1 DLC1 DNMT3L DVL1 ECSIT EIF2AK4 ELP3 EP300 EPN2 ERBB2 ERBIN EWSR1 FBXL12 FBXO30 FBXW7 FHL5 FOXG1 FRZB GDF6 GLI3 GMEB1 GSC HBP1 HIPK2 HOXA13 HOXA5 HOXC8 HOXD13 ING2 INPP4A IRF2BP1 KAT2B KMT2D LEF1 LEMD3 LMNA MAP2K3 MAPK1 MAST4 MBD1 MECOM MED6 MEN1 MGA MLH1 MLH3 MRTFB MSH2 MUTYH NAT9 NEDD4 NEDD9 NEUROG1 NKX3-2 NOTCH2 NRAS OAZ1 OAZ3 PAK1 PARD3 PDGFRL PIAS1 PIAS4 PIGQ PLEKHB1 PREB PSMB4 PSMD1 PSMD11 PTPN12 PUM1 RAB2B RAB30 RAB34 RAB38 RAB3B RAB6B RAC2 RAN RAP2A RASD2 RASL12 RFX1 RHEBL1 RHOG RPS27A SF3B1 SKI SKIL SMAD2 SMAD3 SMAD4 SMAD5 SMAD6 SMARCE1 SMURF1 SMURF2 SNIP1 SNRNP70 SOX5 SQSTM1 SS18L1 STARD13 STK11 STUB1 SUV39H1 TCF20 TET2 TGFBR1 TLR2 TNNT1 TOB1 TRIP6 TTF1 TTF2 UBA52 UBC UBE2Z UBXN1 USP45 VEPH1 WDR77 XPC XPO1 YAP1 YY1 ZBTB44 ZDHHC3 ZEB2 ZNF251 ZNF423 ZNF510 ZNF512B ZNF521 ZNF76 ZNF8 ZSCAN4	48 interacting genes: AKT1 ANXA7 APPBP2 ATR BARD1 BRCA1 CCDC180 CDC14B CDC42 CDKN1A CHEK2 CREBBP DVL1 EPHA2 ESR1 ESR2 EXO1 FBP1 FBP2 FGFR4 GALNT12 GRB7 HDAC6 HRAS HUS1 LEF1 MAX MSH3 MSH6 MYC PCNA PPP3R2 RAD1 RAD9A RPA4 RPP14 SMAD1 SMC1A SMN1 STX17 SUMO2 TDRD7 TK1 TREX1 TRIM29 USP10 XPA ZNF510
Entrez ID		4086	4436
HPRD ID		03356	00389
Ensembl ID		ENSG00000170365	ENSG00000095002
Uniprot IDs		Q15797	A0A2R8Y6P0 P43246
PDB IDs		1KHU 2LAW 2LAX 2LAY 2LAZ 2LB0 2LB1 3Q47 3Q4A 5ZOK	2O8B 2O8C 2O8D 2O8E 2O8F 3THW 3THX 3THY 3THZ
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?