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SMAD1 and NOTCH2
Data Source:
HPRD
(two hybrid)
SMAD1
NOTCH2
Description
SMAD family member 1
notch receptor 2
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nuclear Inner Membrane
Nucleoplasm
Cytoplasm
Cytosol
Integral Component Of Membrane
Protein-containing Complex
SMAD Protein Complex
Heteromeric SMAD Protein Complex
Golgi Membrane
Extracellular Region
Nucleus
Nucleoplasm
Endoplasmic Reticulum Membrane
Plasma Membrane
Integral Component Of Plasma Membrane
Cilium
Cell Surface
Membrane
Receptor Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
DEAD/H-box RNA Helicase Binding
Protein Kinase Binding
Identical Protein Binding
Metal Ion Binding
Co-SMAD Binding
I-SMAD Binding
Primary MiRNA Binding
Calcium Ion Binding
Protein Binding
Enzyme Binding
Signaling Receptor Activity
NF-kappaB Binding
Biological Process
MAPK Cascade
Ureteric Bud Development
Mesodermal Cell Fate Commitment
Osteoblast Fate Commitment
Regulation Of Transcription By RNA Polymerase II
Protein Phosphorylation
Inflammatory Response
Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
SMAD Protein Complex Assembly
Gamete Generation
Negative Regulation Of Cell Population Proliferation
Anatomical Structure Morphogenesis
Embryonic Pattern Specification
Positive Regulation Of Gene Expression
Protein Deubiquitination
Cell Differentiation
BMP Signaling Pathway
Midbrain Development
Hindbrain Development
Primary MiRNA Processing
Homeostatic Process
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Cartilage Development
Cardiac Muscle Cell Proliferation
Bone Development
SMAD Protein Signal Transduction
Positive Regulation Of Cartilage Development
Cellular Response To Organic Cyclic Compound
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Sprouting Angiogenesis
Negative Regulation Of Transcription By RNA Polymerase II
In Utero Embryonic Development
Cell Fate Determination
Heart Looping
Morphogenesis Of An Epithelial Sheet
Marginal Zone B Cell Differentiation
Inflammatory Response To Antigenic Stimulus
Pulmonary Valve Morphogenesis
Transcription Initiation From RNA Polymerase II Promoter
Apoptotic Process
Humoral Immune Response
Cell Cycle Arrest
Notch Signaling Pathway
Multicellular Organism Development
Nervous System Development
Axon Guidance
Animal Organ Morphogenesis
Negative Regulation Of Gene Expression
Positive Regulation Of Keratinocyte Proliferation
Stem Cell Population Maintenance
Hemopoiesis
Embryonic Limb Morphogenesis
Positive Regulation Of BMP Signaling Pathway
Multicellular Organism Growth
Intrahepatic Bile Duct Development
Wound Healing
Defense Response To Bacterium
Myeloid Dendritic Cell Differentiation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Osteoclast Differentiation
Negative Regulation Of Growth Rate
Positive Regulation Of Ras Protein Signal Transduction
Bone Remodeling
Atrial Septum Morphogenesis
Placenta Blood Vessel Development
Ciliary Body Morphogenesis
Notch Signaling Involved In Heart Development
Positive Regulation Of ERK1 And ERK2 Cascade
Left/right Axis Specification
Proximal Tubule Development
Glomerular Visceral Epithelial Cell Development
Glomerular Capillary Formation
Hepatocyte Proliferation
Cholangiocyte Proliferation
Regulation Of Actin Cytoskeleton Reorganization
Regulation Of Osteoclast Development
Pathways
Signaling by BMP
Ub-specific processing proteases
RUNX2 regulates bone development
Pre-NOTCH Processing in the Endoplasmic Reticulum
Pre-NOTCH Transcription and Translation
Pre-NOTCH Processing in Golgi
Pre-NOTCH Processing in Golgi
NOTCH2 intracellular domain regulates transcription
NOTCH2 intracellular domain regulates transcription
NOTCH2 Activation and Transmission of Signal to the Nucleus
NOTCH2 Activation and Transmission of Signal to the Nucleus
Notch-HLH transcription pathway
Defective LFNG causes SCDO3
NOTCH4 Intracellular Domain Regulates Transcription
Drugs
Diseases
Alagille syndrome
Type II diabetes mellitus
Hajdu-Cheney syndrome
GWAS
HDL cholesterol levels (
32203549
)
Hemoglobin (
32888494
)
Lung function (FEV1) (
30061609
)
Malaria (
31844061
)
Midgestational cytokine/chemokine levels (maternal genetic effect) (
30134952
)
Panic disorder (
31712720
)
Red cell distribution width (
32888494
)
Response to cognitive-behavioural therapy in anxiety disorder (
26989097
)
Blood protein levels (
30072576
)
Hepatocyte growth factor levels (
25998175
)
Nevus count or cutaneous melanoma (
32341527
)
Systemic lupus erythematosus (
28714469
)
Type 2 diabetes (
18372903
30054458
30297969
)
Interacting Genes
160 interacting genes:
ACVR1
ACVRL1
AKR1B1
ANKRD27
AP2A2
APC
APP
AR
ARHGEF6
ARL4D
AXIN2
BMPR1A
BTBD2
BTG2
BUB1
CAMSAP1
CCND1
CDK7
CDK9
CHMP3
CILK1
COL4A1
CTNNA1
DACH1
DLC1
DNMT3L
DVL1
ECSIT
EIF2AK4
ELP3
EP300
EPN2
ERBB2
ERBIN
EWSR1
FBXL12
FBXO30
FBXW7
FHL5
FOXG1
FRZB
GDF6
GLI3
GMEB1
GSC
HBP1
HIPK2
HOXA13
HOXA5
HOXC8
HOXD13
ING2
INPP4A
IRF2BP1
KAT2B
KMT2D
LEF1
LEMD3
LMNA
MAP2K3
MAPK1
MAST4
MBD1
MECOM
MED6
MEN1
MGA
MLH1
MLH3
MRTFB
MSH2
MUTYH
NAT9
NEDD4
NEDD9
NEUROG1
NKX3-2
NOTCH2
NRAS
OAZ1
OAZ3
PAK1
PARD3
PDGFRL
PIAS1
PIAS4
PIGQ
PLEKHB1
PREB
PSMB4
PSMD1
PSMD11
PTPN12
PUM1
RAB2B
RAB30
RAB34
RAB38
RAB3B
RAB6B
RAC2
RAN
RAP2A
RASD2
RASL12
RFX1
RHEBL1
RHOG
RPS27A
SF3B1
SKI
SKIL
SMAD2
SMAD3
SMAD4
SMAD5
SMAD6
SMARCE1
SMURF1
SMURF2
SNIP1
SNRNP70
SOX5
SQSTM1
SS18L1
STARD13
STK11
STUB1
SUV39H1
TCF20
TET2
TGFBR1
TLR2
TNNT1
TOB1
TRIP6
TTF1
TTF2
UBA52
UBC
UBE2Z
UBXN1
USP45
VEPH1
WDR77
XPC
XPO1
YAP1
YY1
ZBTB44
ZDHHC3
ZEB2
ZNF251
ZNF423
ZNF510
ZNF512B
ZNF521
ZNF76
ZNF8
ZSCAN4
31 interacting genes:
ANKRD28
CCR2
CNTN1
CRKL
CST6
DLL1
DTX1
DTX3
EGFL7
EPSTI1
GSK3B
IL13RA2
IL24
ITIH5
JAG1
JAG2
KLK5
LFNG
LRATD2
MAML1
MAML2
MAML3
MFNG
MTA3
MYOC
PSEN1
PSEN2
PSMC3IP
RBPJ
SMAD1
ST14
Entrez ID
4086
4853
HPRD ID
03356
02606
Ensembl ID
ENSG00000170365
ENSG00000134250
Uniprot IDs
Q15797
Q04721
Q6IQ50
Q9UFD5
PDB IDs
1KHU
2LAW
2LAX
2LAY
2LAZ
2LB0
2LB1
3Q47
3Q4A
5ZOK
2OO4
5MWB
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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