TFIP11 and HDAC4

Data Source:
BioGRID (two hybrid)

		TFIP11	HDAC4
Description		tuftelin interacting protein 11	histone deacetylase 4
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleoplasm Spliceosomal Complex Nucleolus Cytoplasm Nuclear Speck Extracellular Matrix U2-type Post-mRNA Release Spliceosomal Complex Catalytic Step 2 Spliceosome	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck Transcription Repressor Complex Z Disc Neuromuscular Junction A Band Actomyosin
	Molecular Function	Nucleic Acid Binding Protein Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding SUMO Transferase Activity Protein Kinase Binding Potassium Ion Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Activating Transcription Factor Binding Identical Protein Binding Histone Deacetylase Binding Sequence-specific DNA Binding Repressing Transcription Factor Binding Promoter-specific Chromatin Binding
	Biological Process	Spliceosomal Complex Disassembly MRNA Splicing, Via Spliceosome RNA Processing Biomineral Tissue Development Negative Regulation Of Protein-containing Complex Assembly Protection From Non-homologous End Joining At Telomere Negative Regulation Of Protein Binding Negative Regulation Of DNA Ligase Activity Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Osteoblast Development Chromatin Remodeling Protein Deacetylation Inflammatory Response Nervous System Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Lamellipodium Assembly Negative Regulation Of Myotube Differentiation Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Response To Denervation Involved In Regulation Of Muscle Adaptation Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Smooth Muscle Cell Migration Histone Deacetylation Protein Sumoylation B Cell Differentiation Positive Regulation Of Protein Sumoylation Peptidyl-lysine Deacetylation Regulation Of Gene Expression, Epigenetic B Cell Activation Response To Drug Regulation Of Protein Binding Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Glycolytic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of DNA-binding Transcription Factor Activity Response To Interleukin-1 Histone H3 Deacetylation Histone H4 Deacetylation Cellular Response To Mechanical Stimulus Cellular Response To Tumor Necrosis Factor Cellular Response To Parathyroid Hormone Stimulus Positive Regulation Of Male Mating Behavior Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Reactive Oxygen Species Biosynthetic Process
Pathways		mRNA Splicing - Major Pathway	NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins RUNX2 regulates chondrocyte maturation RUNX3 regulates p14-ARF
Drugs			Zinc Belinostat Romidepsin Panobinostat N-hydroxy-5-[(3-phenyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)carbonyl]thiophene-2-carboxamide 2,2,2-TRIFLUORO-1-{5-[(3-PHENYL-5,6-DIHYDROIMIDAZO[1,2-A]PYRAZIN-7(8H)-YL)CARBONYL]THIOPHEN-2-YL}ETHANE-1,1-DIOL Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Brachydacytly-mental retardation syndrome and Smith-Magenis syndrome
GWAS			Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals ( 22959728) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blond vs. brown/black hair color ( 30531825) Body size at age 10 ( 32376654) Chronotype ( 30696823) CV-A6-associated hand, foot, and mouth disease (severe vs mild) ( 32634583) Diastolic blood pressure ( 30224653 30487518) Estimated glomerular filtration rate after 5 years in renal transplantation (recipient effect) ( 30920136) Heel bone mineral density ( 30598549) Intra-individual response time variability (selective attention) ( 30287865) Male-pattern baldness ( 22693459) Mean arterial pressure ( 29403010 30487518) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 30429480) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507) Perioperative myocardial infarction in coronary artery bypass surgery ( 25948407) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Systolic blood pressure ( 30487518)
Interacting Genes		232 interacting genes: AARD ABI2 ABLIM3 AIMP2 ANKRD11 AP1M1 ARHGEF9 ARMC7 ARMCX1 ARNT2 ATP5PO ATPAF2 AXIN1 BAZ2B BCL6 BHLHA9 BMF BRD1 BYSL C1orf109 C2CD6 CARD9 CAVIN3 CBX8 CCDC102B CCDC116 CCDC120 CCDC121 CCDC13 CCDC146 CCDC187 CCDC196 CCDC42 CCDC57 CCDC6 CCDC68 CCDC96 CCHCR1 CCND3 CCNG1 CCNL1 CCP110 CDKN1A CDR2L CENPU CEP57 CEP57L1 CEP95 CFAP206 COQ8A COX5B CT55 CWF19L2 DAXX DDX25 DES DGCR6 DISC1 DPPA3 DTNB EAF2 EIF3A EIF3D ENOX2 EPM2AIP1 EXOC3L1 EXOC8 EXOSC5 FAM13C FAM156A FAM161A FAM161B FAM50B FAM81A FAM90A1 FANCG FGA GADD45GIP1 GAS2L2 GCC1 GCFC2 GEM GFAP GNG4 GOLGA1 GOLGA2 GPS2 GRAP2 GSE1 HAUS1 HDAC4 HIP1R HMG20B HOOK1 HSF2BP IKBIP IL16 IMP3 JRK KANK2 KANSL1 KAT5 KDM1A KIF3C KIF9 KIFC3 KIZ KRT1 KRT20 KRT6A KRT6B KRT6C KRT8 LATS1 LCA5 LCA5L LENG1 LIN37 LMNB2 LMO1 LMO2 LMO4 LSM3 LSP1P3 LYSMD1 MAB21L2 MCM7 MDM2 METTL17 MFAP1 MKRN3 MRPL11 MTFR2 MXD3 MYO15B MYOM1 NDC80 NDE1 NDN NEK6 NFKBID NFU1 NSMF NUP88 ODAD3 OIP5 PBX3 PBX4 PCM1 PDE4DIP PHF1 PIBF1 PICK1 PKN3 PLK4 POLL POLR1C POM121 PPFIA3 PPP1R16A PPP1R16B PPP1R18 PRPF31 PSMA4 PSMC5 PSTPIP1 PTCD1 RCOR3 RHNO1 RIN1 RNF6 RRP7A RUNX1T1 RXRB S100P SAP30BP SCNM1 SFR1 SGF29 SH2D4A SH3GLB1 SMARCB1 SMARCE1 SNAPIN SNRPB SNW1 SNX20 SNX32 SOGA1 SPG21 SSX2IP STRA8 STRN SYCE1 TBC1D30 TBRG4 TCAF1 TDP2 TFPT THAP7 THAP8 TNNT1 TP53 TRAF3IP3 TRAPPC4 TRIM45 TRIML2 TSG101 TSGA10IP TSHZ2 TSHZ3 TSPYL4 TUFT1 TXLNA TXN2 UBTFL1 USP2 USP6 USP7 VPS37C VPS39 WAC WASHC3 ZC2HC1C ZFYVE26 ZGPAT ZMAT2 ZNF417 ZNF572 ZNF587 ZNF777 ZSCAN12	123 interacting genes: ACTA1 ANKRA2 ANKRD11 APP AR ASB15 ATF3 ATRX BCL6 BCOR BEGAIN BICD2 BLZF1 BORCS8-MEF2B BRMS1 CACNA1C CADPS CALCOCO2 CAMK4 CBX5 CCDC125 CCDC136 CCNDBP1 CDKN1A CDPF1 CDR2 CDR2L CEBPD CEP70 CIITA CSRP3 CTBP1 DYDC1 EFEMP2 EFHC2 ESR1 FCHSD2 FSD2 GATA1 GCM1 GOLGA2 GOLGA6L9 GRIPAP1 GSK3B HAP1 HDAC3 HDAC7 HDAC9 HNF4A HOOK2 HSF2BP IFRD1 IKZF2 INCA1 JDP2 KRT27 KRT31 KRT33B KRT34 KRT35 KRT38 KRT40 LCOR LDOC1 LZTR1 MAP1S MAPK1 MAPK3 MECOM MEF2A MEF2B MEF2C MEF2D MEGF10 MID2 MIF4GD MTUS2 NACC1 NCOR2 NFKB2 NFKBID NFKBIE NPPB NR1H2 NR2C1 NR2C2 PICK1 PNMA1 PPARD PPARG PTPA RANBP2 RARA RBBP4 REV3L RFXANK RINT1 RUNX2 RUNX3 RUVBL2 RXRA SMAD3 SRF SS18L1 SSX2IP SUMO1 SUMO2 SYK TFIP11 TLE5 TNFRSF14 TRIB3 TRIM27 TSGA10 UBE2I VPS52 YWHAE YWHAG YWHAQ YWHAZ ZBTB16 ZMYND12 ZNF354A
Entrez ID		24144	9759
HPRD ID		11628	05610
Ensembl ID		ENSG00000100109	ENSG00000068024
Uniprot IDs		A0A024R1I7 Q9UBB9	P56524
PDB IDs			2H8N 2O94 2VQJ 2VQM 2VQO 2VQQ 2VQV 2VQW 3UXG 3UZD 3V31 4CBT 4CBY 5A2S 5ZOO 5ZOP 6FYZ
Enriched GO Terms of Interacting Partners?
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