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TFIP11 and PSMC5
Data Source:
BioGRID
(two hybrid)
TFIP11
PSMC5
Description
tuftelin interacting protein 11
proteasome 26S subunit, ATPase 5
Image
No pdb structure
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleoplasm
Spliceosomal Complex
Nucleolus
Cytoplasm
Nuclear Speck
Extracellular Matrix
U2-type Post-mRNA Release Spliceosomal Complex
Catalytic Step 2 Spliceosome
Proteasome Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Proteasome Regulatory Particle, Base Subcomplex
Membrane
Inclusion Body
Proteasome Accessory Complex
Cytoplasmic Vesicle
Nuclear Proteasome Complex
Cytosolic Proteasome Complex
Extracellular Exosome
Blood Microparticle
Postsynapse
Molecular Function
Nucleic Acid Binding
Protein Binding
Protein Binding
ATP Binding
Transcription Factor Binding
ATPase Activity
TBP-class Protein Binding
Thyrotropin-releasing Hormone Receptor Binding
Biological Process
Spliceosomal Complex Disassembly
MRNA Splicing, Via Spliceosome
RNA Processing
Biomineral Tissue Development
Negative Regulation Of Protein-containing Complex Assembly
Protection From Non-homologous End Joining At Telomere
Negative Regulation Of Protein Binding
Negative Regulation Of DNA Ligase Activity
Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
MAPK Cascade
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Regulation Of Transcription By RNA Polymerase II
Regulation Of Cellular Amino Acid Metabolic Process
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Protein Deubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tumor Necrosis Factor-mediated Signaling Pathway
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Negative Regulation Of Programmed Cell Death
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of MRNA Stability
Post-translational Protein Modification
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly
Modulation Of Chemical Synaptic Transmission
T Cell Receptor Signaling Pathway
Transmembrane Transport
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Interleukin-1-mediated Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Inclusion Body Assembly
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Hematopoietic Stem Cell Differentiation
Pathways
mRNA Splicing - Major Pathway
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Interacting Genes
232 interacting genes:
AARD
ABI2
ABLIM3
AIMP2
ANKRD11
AP1M1
ARHGEF9
ARMC7
ARMCX1
ARNT2
ATP5PO
ATPAF2
AXIN1
BAZ2B
BCL6
BHLHA9
BMF
BRD1
BYSL
C1orf109
C2CD6
CARD9
CAVIN3
CBX8
CCDC102B
CCDC116
CCDC120
CCDC121
CCDC13
CCDC146
CCDC187
CCDC196
CCDC42
CCDC57
CCDC6
CCDC68
CCDC96
CCHCR1
CCND3
CCNG1
CCNL1
CCP110
CDKN1A
CDR2L
CENPU
CEP57
CEP57L1
CEP95
CFAP206
COQ8A
COX5B
CT55
CWF19L2
DAXX
DDX25
DES
DGCR6
DISC1
DPPA3
DTNB
EAF2
EIF3A
EIF3D
ENOX2
EPM2AIP1
EXOC3L1
EXOC8
EXOSC5
FAM13C
FAM156A
FAM161A
FAM161B
FAM50B
FAM81A
FAM90A1
FANCG
FGA
GADD45GIP1
GAS2L2
GCC1
GCFC2
GEM
GFAP
GNG4
GOLGA1
GOLGA2
GPS2
GRAP2
GSE1
HAUS1
HDAC4
HIP1R
HMG20B
HOOK1
HSF2BP
IKBIP
IL16
IMP3
JRK
KANK2
KANSL1
KAT5
KDM1A
KIF3C
KIF9
KIFC3
KIZ
KRT1
KRT20
KRT6A
KRT6B
KRT6C
KRT8
LATS1
LCA5
LCA5L
LENG1
LIN37
LMNB2
LMO1
LMO2
LMO4
LSM3
LSP1P3
LYSMD1
MAB21L2
MCM7
MDM2
METTL17
MFAP1
MKRN3
MRPL11
MTFR2
MXD3
MYO15B
MYOM1
NDC80
NDE1
NDN
NEK6
NFKBID
NFU1
NSMF
NUP88
ODAD3
OIP5
PBX3
PBX4
PCM1
PDE4DIP
PHF1
PIBF1
PICK1
PKN3
PLK4
POLL
POLR1C
POM121
PPFIA3
PPP1R16A
PPP1R16B
PPP1R18
PRPF31
PSMA4
PSMC5
PSTPIP1
PTCD1
RCOR3
RHNO1
RIN1
RNF6
RRP7A
RUNX1T1
RXRB
S100P
SAP30BP
SCNM1
SFR1
SGF29
SH2D4A
SH3GLB1
SMARCB1
SMARCE1
SNAPIN
SNRPB
SNW1
SNX20
SNX32
SOGA1
SPG21
SSX2IP
STRA8
STRN
SYCE1
TBC1D30
TBRG4
TCAF1
TDP2
TFPT
THAP7
THAP8
TNNT1
TP53
TRAF3IP3
TRAPPC4
TRIM45
TRIML2
TSG101
TSGA10IP
TSHZ2
TSHZ3
TSPYL4
TUFT1
TXLNA
TXN2
UBTFL1
USP2
USP6
USP7
VPS37C
VPS39
WAC
WASHC3
ZC2HC1C
ZFYVE26
ZGPAT
ZMAT2
ZNF417
ZNF572
ZNF587
ZNF777
ZSCAN12
80 interacting genes:
AKT1
AZIN2
BACH2
BFSP2
CAMK2A
CCDC136
CDC42
CFAP206
EPHA8
ERCC3
ERCC6
ESR1
ESR2
ESRRA
ESRRG
FOS
GTF2B
HARS1
HNF4G
HOMER3
HSPA1A
HTT
INSIG2
KRT15
KRT27
KRT31
KRT38
KRT40
LAMB1
LAMC1
MDM2
MYO18B
NR1H3
NR1I2
NR1I3
NR3C2
PDC
PDCL
PLEKHO1
PPARD
PRKN
PSMC1
PSMC2
PSMC3
PSMC4
PSMC6
PSMD11
PSMD12
RAD23A
RARA
RARB
RARG
RORA
RORB
RORC
RXRA
SCOC
SHOC2
SIRPA
SKA1
SP1
SSNA1
SUMO2
TAF10
TFIP11
THAP11
THRB
TNNI2
TNNI3
TNNT1
TP53
TPM1
TPM3
TRIP11
UBC
UBE3C
UBLCP1
USP4
VDR
VIM
Entrez ID
24144
5705
HPRD ID
11628
03400
Ensembl ID
ENSG00000100109
ENSG00000087191
Uniprot IDs
A0A024R1I7
Q9UBB9
A0A140VJS3
P62195
PDB IDs
2KRK
3KW6
5GJQ
5GJR
5L4G
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
5VGZ
5VHF
5VHH
5VHI
5VHJ
5VHM
5VHN
5VHO
5VHP
5VHQ
5VHR
5VHS
6MSB
6MSD
6MSG
6MSH
6MSJ
6MSK
6WJD
6WJN
Enriched GO Terms of Interacting Partners
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