U2AF1L5 and U2AF2

Data Source:
BioGRID (two hybrid)

		U2AF1L5	U2AF2
Description		U2 small nuclear RNA auxiliary factor 1 like 5	U2 small nuclear RNA auxiliary factor 2
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GO Annotations	Cellular Component	Nucleoplasm Spliceosomal Complex Nuclear Speck U2AF Complex	Commitment Complex Prp19 Complex Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck U2-type Prespliceosome U2AF Complex
	Molecular Function	Protein Binding Pre-mRNA 3'-splice Site Binding Metal Ion Binding	RNA Binding Protein Binding Poly-pyrimidine Tract Binding Enzyme Binding Pre-mRNA 3'-splice Site Binding C2H2 Zinc Finger Domain Binding
	Biological Process	MRNA Splicing, Via Spliceosome	MRNA Splicing, Via Spliceosome MRNA Processing RNA Export From Nucleus MRNA Export From Nucleus MRNA 3'-end Processing Negative Regulation Of Protein Ubiquitination Positive Regulation Of RNA Splicing Negative Regulation Of MRNA Splicing, Via Spliceosome
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS			HDL cholesterol levels ( 32203549) Menopause (age at onset) ( 26414677)
Interacting Genes		15 interacting genes: AP1B1 AP2B1 CARNMT1 EFHC2 HNRNPK KRT1 KRT75 MEOX2 MLH1 SNRNP35 SRRM4 SRSF3 TRA2B U2AF2 ZNF417	75 interacting genes: APBB1 ATXN1 BEND7 CCAR1 CDC42 CHERP CHIC2 CPSF7 DACH1 DDX39B DDX6 DPPA2 DVL2 EPB41 FUBP1 GEMIN2 GLIS2 HLA-DMA HMBOX1 IL7R INO80B KHDC4 KHDRBS3 LURAP1 MAP1B MRPL15 NKAPD1 OTUB2 PHF5A PIN1 POLR2A PRPF3 PRPF40A PUF60 QKI RBFOX2 RBM11 RBM39 RBM4 RBMY1F RBMY1J SAP30BP SCAF11 SF1 SF3B1 SF3B2 SF3B3 SF3B4 SF3B5 SF3B6 SMAD5 SNRPA SRPK1 SRPK2 SRSF1 SRSF11 SRSF3 STAC3 SUGP1 SUMO2 TCERG1 TCF23 THAP1 TLE5 TOP1 U2AF1 U2AF1L5 WT1 ZNF107 ZNF526 ZNF57 ZNF71 ZNF835 ZRSR2 ZRSR2P1
Entrez ID		102724594	11338
HPRD ID			01872
Ensembl ID		ENSG00000275895	ENSG00000063244
Uniprot IDs		P0DN76 Q01081	P26368
PDB IDs		1JMT	1JMT 1O0P 1OPI 1U2F 2G4B 2HZC 2M0G 2U2F 2YH0 2YH1 3VAF 3VAG 3VAH 3VAI 3VAJ 3VAK 3VAL 3VAM 4FXW 4TU7 4TU8 4TU9 5EV1 5EV2 5EV3 5EV4 5W0G 5W0H 6TR0 6XLV 6XLW 6XLX
Enriched GO Terms of Interacting Partners?
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