JUN and TDG

Data Source:
HPRD (in vivo, two hybrid)

		JUN	TDG
Description		Jun proto-oncogene, AP-1 transcription factor subunit	thymine DNA glycosylase
Image
GO Annotations	Cellular Component	Nuclear Chromosome Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytosol Plasma Membrane Transcription Factor AP-1 Complex	Nucleus Nucleoplasm Plasma Membrane
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity RNA Binding GTPase Activator Activity Protein Binding Transcription Factor Binding Enzyme Binding Ubiquitin Protein Ligase Binding CAMP Response Element Binding Identical Protein Binding Ubiquitin-like Protein Ligase Binding Protein-containing Complex Binding R-SMAD Binding HMG Box Domain Binding Sequence-specific Double-stranded DNA Binding	Magnesium Ion Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Uracil DNA N-glycosylase Activity Protein Binding ATP Binding Transcription Factor Binding Pyrimidine-specific Mismatch Base Pair DNA N-glycosylase Activity DNA N-glycosylase Activity Protein Domain Specific Binding Mismatched DNA Binding Sodium Ion Binding Chloride Ion Binding SUMO Binding Protein Homodimerization Activity Protein Self-association G/U Mismatch-specific Uracil-DNA Glycosylase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Release Of Cytochrome C From Mitochondria Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Ras Protein Signal Transduction Aging Learning Circadian Rhythm Response To Radiation Response To Mechanical Stimulus Response To Lipopolysaccharide Response To Cytokine Cellular Response To Reactive Oxygen Species Fc-epsilon Receptor Signaling Pathway Regulation Of Cell Population Proliferation Response To Drug Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Negative Regulation By Host Of Viral Transcription Positive Regulation By Host Of Viral Transcription Positive Regulation Of Monocyte Differentiation Positive Regulation Of DNA Replication Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-binding Transcription Factor Activity Cellular Response To Potassium Ion Starvation Response To CAMP Regulation Of Cell Cycle Membrane Depolarization SMAD Protein Signal Transduction Cellular Response To Cadmium Ion Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Positive Regulation Of DNA-templated Transcription, Initiation	Negative Regulation Of Transcription By RNA Polymerase II Base-excision Repair Base-excision Repair, AP Site Formation Mismatch Repair Chromatin Organization Oxidative DNA Demethylation Regulation Of Gene Expression, Epigenetic Depyrimidination Regulation Of Embryonic Development DNA Demethylation Regulation Of DNA N-glycosylase Activity
Pathways		Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) FCERI mediated MAPK activation Activation of the AP-1 family of transcription factors Activation of anterior HOX genes in hindbrain development during early embryogenesis MAPK6/MAPK4 signaling TP53 Regulates Transcription of DNA Repair Genes Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Regulation of PTEN gene transcription Regulation of PTEN gene transcription Estrogen-dependent gene expression WNT5:FZD7-mediated leishmania damping	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Displacement of DNA glycosylase by APEX1 SUMOylation of DNA damage response and repair proteins TET1,2,3 and TDG demethylate DNA
Drugs		Adapalene Vinblastine Pseudoephedrine Irbesartan Arsenic trioxide LGD-1550
Diseases
GWAS		Cognitive performance ( 19734545) Night sleep phenotypes ( 27126917)	Glucagon levels in response to oral glucose tolerance test (fasting) ( 29093273) Metabolite levels ( 23823483)
Interacting Genes		180 interacting genes: ABL1 AKAP5 APLP2 APP AR ARRB1 ATF1 ATF2 ATF3 ATF4 BATF BATF2 BBS7 BCL3 BCL6 BLM BRCA1 CASP9 CCND1 CEBPE CEBPG CLINT1 COP1 COPS5 CREB3 CREB5 CREBBP CSNK2A1 DACH1 DDIT3 DDX21 DHX9 DNMT3L EDF1 EGR1 ELF3 ELOF1 EN1 EP300 EPAS1 ERG ESR1 ETS1 ETS2 ETV1 ETV4 EWSR1 FBXW7 FOS FOSB FOSL1 FOSL2 GATA2 GOPC GSK3B GTF2B GTF2E2 GTF2F1 GTF2F2 HCFC1 HDAC3 HDAC9 HDGF HHEX HIF1A HMGA1 HNRNPM HOXA9 HOXC8 HSP90AA1 HSPA8 IKBKB IRAK1 ITCH ITPK1 JDP2 KLF5 KMT2C KPNA2 M6PR MACF1 MAF MAFB MAP2K4 MAP2K7 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 MAPKAPK5 MAPRE3 MBD3 MDM2 MOK MTA1 MYBBP1A MYOD1 NACA NAT14 NCOA1 NCOA2 NCOA3 NCOA6 NCOR2 NEDD4 NELFB NFE2L1 NFE2L2 NFYA NR3C1 NR5A1 NRIP1 NTRK3 PACS1 PHOX2A PIAS1 PIAS2 PIN1 POU1F1 PPARG PPP3CB PPP4C PRKD1 PRKDC PRRC2A RB1 RBM39 RELA RNF187 RPL18A RPS6KA2 RUNX1 RUNX2 SKI SMAD2 SMAD3 SMAD4 SMARCD1 SMARCD3 SNAPC5 SNRK SOX10 SOX8 SP1 SPI1 SPIB STAT1 STAT3 STAT4 STRN4 SUMO1 SUMO2 SUMO3 SUMO4 TAF1 TAF4 TBP TCF20 TCF4 TDG TGIF1 TOP1 TOP2A TP53 TPM1 TPM2 TRAF2 TRIP4 TSC22D3 TSG101 UBB UBC UBE2I USP6 VAV1 VDR ZBTB7C	36 interacting genes: AR CREBBP CRK DDX39B DNMT3B DTL EP300 EPM2A ESR1 HUS1 IKZF1 JUN JUNB MX1 NKX2-1 NR3C1 PCNA PGR PML RAD1 RAD23B RAD9A RXRA SERBP1 SIRT6 SKIL SMAD4 SNIP1 STAT3 SUMO1 SUMO2 SUMO3 THRA UBE2I VDR XPC
Entrez ID		3725	6996
HPRD ID		01302	03251
Ensembl ID		ENSG00000177606	ENSG00000139372
Uniprot IDs		P05412	B4DI29 B4E127 Q13569
PDB IDs		1A02 1FOS 1JNM 1JUN 1S9K 1T2K 5FV8 5T01	1WYW 2D07 2RBA 3UFJ 3UO7 3UOB 4FNC 4JGC 4XEG 4Z3A 4Z47 4Z7B 4Z7Z 5CYS 5FF8 5HF7 5JXY 5T2W 6U15 6U16 6U17
Enriched GO Terms of Interacting Partners?
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