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JUN and COPS5
Data Source:
HPRD
(in vitro)
JUN
COPS5
Description
Jun proto-oncogene, AP-1 transcription factor subunit
COP9 signalosome subunit 5
Image
GO Annotations
Cellular Component
Nuclear Chromosome
Chromatin
Euchromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytosol
Plasma Membrane
Transcription Factor AP-1 Complex
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Eukaryotic Translation Initiation Factor 3 Complex
Synaptic Vesicle
COP9 Signalosome
Perinuclear Region Of Cytoplasm
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Activating Transcription Factor Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
RNA Binding
GTPase Activator Activity
Protein Binding
Transcription Factor Binding
Enzyme Binding
Ubiquitin Protein Ligase Binding
CAMP Response Element Binding
Identical Protein Binding
Ubiquitin-like Protein Ligase Binding
Protein-containing Complex Binding
R-SMAD Binding
HMG Box Domain Binding
Sequence-specific Double-stranded DNA Binding
Transcription Coactivator Activity
Translation Initiation Factor Activity
Metalloendopeptidase Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
Metallopeptidase Activity
NEDD8-specific Protease Activity
Enzyme Binding
Macrophage Migration Inhibitory Factor Binding
Metal Ion Binding
Isopeptidase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Angiogenesis
Release Of Cytochrome C From Mitochondria
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Transforming Growth Factor Beta Receptor Signaling Pathway
Ras Protein Signal Transduction
Aging
Learning
Circadian Rhythm
Response To Radiation
Response To Mechanical Stimulus
Response To Lipopolysaccharide
Response To Cytokine
Cellular Response To Reactive Oxygen Species
Fc-epsilon Receptor Signaling Pathway
Regulation Of Cell Population Proliferation
Response To Drug
Response To Hydrogen Peroxide
Positive Regulation Of Apoptotic Process
Negative Regulation Of DNA Binding
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of GTPase Activity
Negative Regulation By Host Of Viral Transcription
Positive Regulation By Host Of Viral Transcription
Positive Regulation Of Monocyte Differentiation
Positive Regulation Of DNA Replication
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-binding Transcription Factor Activity
Cellular Response To Potassium Ion Starvation
Response To CAMP
Regulation Of Cell Cycle
Membrane Depolarization
SMAD Protein Signal Transduction
Cellular Response To Cadmium Ion
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Positive Regulation Of DNA-templated Transcription, Initiation
Protein Deneddylation
Nucleotide-excision Repair, DNA Damage Recognition
Transcription-coupled Nucleotide-excision Repair
Translation
Translational Initiation
Protein Deubiquitination
Protein Phosphopantetheinylation
Negative Regulation Of Apoptotic Process
Post-translational Protein Modification
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of JNK Cascade
Positive Regulation Of DNA-binding Transcription Factor Activity
Regulation Of Cell Cycle
Regulation Of IRE1-mediated Unfolded Protein Response
Exosomal Secretion
Pathways
Pre-NOTCH Transcription and Translation
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
FCERI mediated MAPK activation
Activation of the AP-1 family of transcription factors
Activation of anterior HOX genes in hindbrain development during early embryogenesis
MAPK6/MAPK4 signaling
TP53 Regulates Transcription of DNA Repair Genes
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Estrogen-dependent gene expression
WNT5:FZD7-mediated leishmania damping
DNA Damage Recognition in GG-NER
Formation of TC-NER Pre-Incision Complex
Cargo recognition for clathrin-mediated endocytosis
Neddylation
Drugs
Adapalene
Vinblastine
Pseudoephedrine
Irbesartan
Arsenic trioxide
LGD-1550
Diseases
GWAS
Cognitive performance (
19734545
)
Night sleep phenotypes (
27126917
)
Interacting Genes
180 interacting genes:
ABL1
AKAP5
APLP2
APP
AR
ARRB1
ATF1
ATF2
ATF3
ATF4
BATF
BATF2
BBS7
BCL3
BCL6
BLM
BRCA1
CASP9
CCND1
CEBPE
CEBPG
CLINT1
COP1
COPS5
CREB3
CREB5
CREBBP
CSNK2A1
DACH1
DDIT3
DDX21
DHX9
DNMT3L
EDF1
EGR1
ELF3
ELOF1
EN1
EP300
EPAS1
ERG
ESR1
ETS1
ETS2
ETV1
ETV4
EWSR1
FBXW7
FOS
FOSB
FOSL1
FOSL2
GATA2
GOPC
GSK3B
GTF2B
GTF2E2
GTF2F1
GTF2F2
HCFC1
HDAC3
HDAC9
HDGF
HHEX
HIF1A
HMGA1
HNRNPM
HOXA9
HOXC8
HSP90AA1
HSPA8
IKBKB
IRAK1
ITCH
ITPK1
JDP2
KLF5
KMT2C
KPNA2
M6PR
MACF1
MAF
MAFB
MAP2K4
MAP2K7
MAPK1
MAPK10
MAPK11
MAPK14
MAPK3
MAPK8
MAPK9
MAPKAPK5
MAPRE3
MBD3
MDM2
MOK
MTA1
MYBBP1A
MYOD1
NACA
NAT14
NCOA1
NCOA2
NCOA3
NCOA6
NCOR2
NEDD4
NELFB
NFE2L1
NFE2L2
NFYA
NR3C1
NR5A1
NRIP1
NTRK3
PACS1
PHOX2A
PIAS1
PIAS2
PIN1
POU1F1
PPARG
PPP3CB
PPP4C
PRKD1
PRKDC
PRRC2A
RB1
RBM39
RELA
RNF187
RPL18A
RPS6KA2
RUNX1
RUNX2
SKI
SMAD2
SMAD3
SMAD4
SMARCD1
SMARCD3
SNAPC5
SNRK
SOX10
SOX8
SP1
SPI1
SPIB
STAT1
STAT3
STAT4
STRN4
SUMO1
SUMO2
SUMO3
SUMO4
TAF1
TAF4
TBP
TCF20
TCF4
TDG
TGIF1
TOP1
TOP2A
TP53
TPM1
TPM2
TRAF2
TRIP4
TSC22D3
TSG101
UBB
UBC
UBE2I
USP6
VAV1
VDR
ZBTB7C
98 interacting genes:
APCS
ARFGAP1
ATM
ATRN
BCL2L14
BCL3
BRD4
BRSK2
CACNA1C
CD274
CD93
CDKN1B
CENPT
CHUK
COPS2
COPS3
COPS4
COPS6
COPS7A
COPS7B
COPS8
COPS9
CUL1
CUL2
CUL3
CUL4A
CUL5
DDB1
DDO
ERN1
ERRFI1
ESR1
F2RL1
GFER
GFI1B
GPS1
GTPBP3
HAND2
HIF1A
HNF4A
HNF4G
HTR6
ITGB2
JUN
JUND
LASP1
MAP2K2
MAP3K11
MAP3K3
MAP3K7
MAP4K3
MAP4K5
MAPK14
MAPRE1
MAX
MDC1
MDM2
MEF2C
MEF2D
MIF
MTRES1
MYG1
NCOA1
NEDD8
NFKB1
NR4A2
NR4A3
OPRM1
PEA15
PGR
PLAC8
PPARG
PPOX
PPP1CC
PRDX2
PRKD1
PTGS2
RAD1
RAD9A
RNF139
RORA
S100A7
SHANK3
SHISA5
SMAD2
SMAD4
SMAD5
SPP1
SREBF2
TOP2A
TP53
TXN
TYK2
UCHL1
USP14
VTN
WNK1
YWHAG
Entrez ID
3725
10987
HPRD ID
01302
06888
Ensembl ID
ENSG00000177606
ENSG00000121022
Uniprot IDs
P05412
A0A024R7W9
Q92905
PDB IDs
1A02
1FOS
1JNM
1JUN
1S9K
1T2K
5FV8
5T01
4D10
4D18
4F7O
4WSN
5JOG
5JOH
5M5Q
6R6H
6R7F
6R7H
6R7I
Enriched GO Terms of Interacting Partners
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