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TDG and STAT3
Data Source:
BioGRID
(two hybrid)
TDG
STAT3
Description
thymine DNA glycosylase
signal transducer and activator of transcription 3
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Plasma Membrane
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Cytosol
Plasma Membrane
RNA Polymerase II Transcription Regulator Complex
Molecular Function
Magnesium Ion Binding
DNA Binding
Damaged DNA Binding
Double-stranded DNA Binding
Uracil DNA N-glycosylase Activity
Protein Binding
ATP Binding
Transcription Factor Binding
Pyrimidine-specific Mismatch Base Pair DNA N-glycosylase Activity
DNA N-glycosylase Activity
Protein Domain Specific Binding
Mismatched DNA Binding
Sodium Ion Binding
Chloride Ion Binding
SUMO Binding
Protein Homodimerization Activity
Protein Self-association
G/U Mismatch-specific Uracil-DNA Glycosylase Activity
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Repressing Transcription Factor Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Nuclear Receptor Activity
Protein Binding
Transcription Factor Binding
Protein Kinase Binding
Protein Phosphatase Binding
Chromatin DNA Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Dimerization Activity
Primary MiRNA Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Base-excision Repair
Base-excision Repair, AP Site Formation
Mismatch Repair
Chromatin Organization
Oxidative DNA Demethylation
Regulation Of Gene Expression, Epigenetic
Depyrimidination
Regulation Of Embryonic Development
DNA Demethylation
Regulation Of DNA N-glycosylase Activity
Negative Regulation Of Transcription By RNA Polymerase II
Temperature Homeostasis
Eye Photoreceptor Cell Differentiation
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Protein Import Into Nucleus
Defense Response
Inflammatory Response
Signal Transduction
Receptor Signaling Pathway Via JAK-STAT
Nervous System Development
Negative Regulation Of Autophagy
Positive Regulation Of Gene Expression
Viral Process
Phosphorylation
Cytokine-mediated Signaling Pathway
Sexual Reproduction
Positive Regulation Of Cell Migration
Intracellular Receptor Signaling Pathway
Response To Estradiol
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Cellular Response To Hormone Stimulus
Leptin-mediated Signaling Pathway
Somatic Stem Cell Population Maintenance
Interleukin-15-mediated Signaling Pathway
Interleukin-7-mediated Signaling Pathway
Interleukin-9-mediated Signaling Pathway
Interleukin-21-mediated Signaling Pathway
Interleukin-23-mediated Signaling Pathway
Regulation Of Cell Population Proliferation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Glucose Homeostasis
Eating Behavior
Response To Peptide Hormone
Cellular Response To Leptin Stimulus
Response To Leptin
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Astrocyte Differentiation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Cell Cycle
Radial Glial Cell Differentiation
Regulation Of Feeding Behavior
Growth Hormone Receptor Signaling Pathway
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Interleukin-6-mediated Signaling Pathway
Interleukin-27-mediated Signaling Pathway
Interleukin-35-mediated Signaling Pathway
Cellular Response To Cytokine Stimulus
T-helper 17 Type Immune Response
T-helper 17 Cell Lineage Commitment
Energy Homeostasis
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Metalloendopeptidase Activity
Positive Regulation Of MiRNA Mediated Inhibition Of Translation
Negative Regulation Of Primary MiRNA Processing
Positive Regulation Of Gene Silencing By MiRNA
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Displacement of DNA glycosylase by APEX1
SUMOylation of DNA damage response and repair proteins
TET1,2,3 and TDG demethylate DNA
Interleukin-6 signaling
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Interleukin-7 signaling
Interleukin-7 signaling
Signaling by SCF-KIT
Signaling by cytosolic FGFR1 fusion mutants
Downstream signal transduction
Signalling to STAT3
Senescence-Associated Secretory Phenotype (SASP)
Signaling by Leptin
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Association of TriC/CCT with target proteins during biosynthesis
Transcriptional regulation of pluripotent stem cells
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
PTK6 Activates STAT3
PTK6 Activates STAT3
Interleukin-20 family signaling
MET activates STAT3
MET activates STAT3
Interleukin-15 signaling
Interleukin-35 Signalling
Interleukin-9 signaling
Interleukin-37 signaling
Interleukin-23 signaling
Interleukin-23 signaling
Interleukin-27 signaling
Interleukin-21 signaling
Transcriptional regulation of granulopoiesis
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Growth hormone receptor signaling
Drugs
ENMD-1198
Diseases
Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
Oral cancer
GWAS
Glucagon levels in response to oral glucose tolerance test (fasting) (
29093273
)
Metabolite levels (
23823483
)
Apolipoprotein B levels (
32203549
)
Atopic dermatitis (
26482879
)
Autoimmune thyroid disease (
32581359
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Composite immunoglobulin trait (IgA/IgG) (
28628107
)
Crohn's disease (
18587394
28067908
21102463
23266558
)
Crohn's disease or systemic sclerosis (
32024964
)
Diastolic blood pressure (
30578418
)
Inflammatory bowel disease (
27569725
28067908
26278503
23128233
)
Itch intensity from mosquito bite (
28199695
)
Itch intensity from mosquito bite adjusted by bite size (
28199695
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
27863252
)
Mean spheric corpuscular volume (
32888494
)
Multiple sclerosis (
31604244
22190364
24076602
21833088
20159113
)
Psoriasis (
25903422
23143594
)
Systemic lupus erythematosus (
28714469
)
Type 2 diabetes (
30054458
)
Ulcerative colitis (
28067908
)
Interacting Genes
36 interacting genes:
AR
CREBBP
CRK
DDX39B
DNMT3B
DTL
EP300
EPM2A
ESR1
HUS1
IKZF1
JUN
JUNB
MX1
NKX2-1
NR3C1
PCNA
PGR
PML
RAD1
RAD23B
RAD9A
RXRA
SERBP1
SIRT6
SKIL
SMAD4
SNIP1
STAT3
SUMO1
SUMO2
SUMO3
THRA
UBE2I
VDR
XPC
208 interacting genes:
ABL2
ADRB2
AMBP
AR
ARFIP2
ASXL1
ATF3
BATF3
BCKDK
BHLHE40
BICD1
BLK
BMX
BRCA1
BRWD1
CA8
CAPN1
CAPNS1
CBL
CCDC87
CCND1
CCR1
CCR5
CDK9
CDKN1A
CEP120
CHTF18
CNDP2
CORO1A
CREBBP
CSF2RB
CSF3R
CXCR4
DAXX
DOK2
DOK3
DTNA
ECH1
EGFR
EIF2AK2
ELP2
EP300
EPHA3
ERBB2
ERBIN
ESR1
FAM117B
FBXW7
FER
FES
FGFR3
FGFR4
FGR
FHL2
FLT1
FOXM1
FYN
GATA1
GATA2
GHR
GNL3
GSTCD
GTF2I
HCK
HDAC1
HDAC2
HDAC3
HES1
HES5
HESX1
HIF1A
HIVEP1
HLA-A
HNF1A
HNRNPM
HOXC11
HSP90AA1
HSP90AB1
IFNAR1
IFNAR2
IGF1R
IL1RAP
IL22RA1
IL23R
IL2RA
IL2RB
IL6R
IL6ST
IL7R
IMPDH2
IRAK1
JAK1
JAK2
JAK3
JUN
KAT5
KDM1A
KHDRBS1
KLF15
KPNA1
KPNA6
KRTAP10-7
LAMB2
LASP1
LCK
LEPR
LMO2
LYN
MAP3K13
MAP3K7
MAPK1
MAPK3
MAPK8
MAPKAPK2
MEG3
MET
MNDA
MORC4
MPZL1
MRPS31
MTOR
MYOD1
NACAD
NCOA1
NDUFA13
NFKB1
NFKBIZ
NIF3L1
NLK
NMI
NR3C1
NR4A1
NUFIP2
NXT2
OFCC1
OGDHL
PAFAH1B2
PAQR7
PCBD2
PDGFRA
PDGFRB
PDIA3
PELP1
PIAS3
PIK3R1
PIK3R2
PIK3R3
PINK1
PML
POM121
PPARD
PRKCD
PTK2B
PTMA
PTPN1
PTPN11
PTPN2
RABGAP1
RAC1
RACK1
RB1
RELA
RET
RPA2
RPL11
RPS6KA5
RPS9
RRAD
SCAF11
SETD7
SH2D2A
SH3BP2
SIAH2
SIN3A
SMARCA4
SPRY1
SRC
SRI
SRRT
SS18L1
STAP2
STAT1
STAT4
STAT5A
STAT5B
STAT6
STMN1
SULT2A1
SUMO4
SUPT20H
SYK
TASOR2
TDG
TM4SF19
TRIM28
TRIP10
TSHR
TSLP
TWIST1
VPS39
WDFY3
ZFPM2
ZNF148
ZNF281
ZNF467
ZNF557
ZNF829
ZNRD2
Entrez ID
6996
6774
HPRD ID
03251
00026
Ensembl ID
ENSG00000139372
ENSG00000168610
Uniprot IDs
B4DI29
B4E127
Q13569
P40763
PDB IDs
1WYW
2D07
2RBA
3UFJ
3UO7
3UOB
4FNC
4JGC
4XEG
4Z3A
4Z47
4Z7B
4Z7Z
5CYS
5FF8
5HF7
5JXY
5T2W
6U15
6U16
6U17
5AX3
5U5S
6NJS
6NUQ
6QHD
6TLC
Enriched GO Terms of Interacting Partners
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