Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
JUN and NEDD4
Data Source:
BioGRID
(two hybrid, affinity chromatography technology)
JUN
NEDD4
Description
Jun proto-oncogene, AP-1 transcription factor subunit
NEDD4 E3 ubiquitin protein ligase
Image
GO Annotations
Cellular Component
Nuclear Chromosome
Chromatin
Euchromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytosol
Plasma Membrane
Transcription Factor AP-1 Complex
Ubiquitin Ligase Complex
Chromatin
Cytoplasm
Golgi Apparatus
Cytosol
Plasma Membrane
Cell Cortex
Apicolateral Plasma Membrane
Protein-containing Complex
Dendritic Spine
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Activating Transcription Factor Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
RNA Binding
GTPase Activator Activity
Protein Binding
Transcription Factor Binding
Enzyme Binding
Ubiquitin Protein Ligase Binding
CAMP Response Element Binding
Identical Protein Binding
Ubiquitin-like Protein Ligase Binding
Protein-containing Complex Binding
R-SMAD Binding
HMG Box Domain Binding
Sequence-specific Double-stranded DNA Binding
Protein Binding
Sodium Channel Inhibitor Activity
Enzyme Binding
Protein Domain Specific Binding
Beta-2 Adrenergic Receptor Binding
Ubiquitin Binding
Phosphoserine Residue Binding
Phosphothreonine Residue Binding
Ubiquitin Protein Ligase Activity
RNA Polymerase Binding
Proline-rich Region Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Angiogenesis
Release Of Cytochrome C From Mitochondria
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Transforming Growth Factor Beta Receptor Signaling Pathway
Ras Protein Signal Transduction
Aging
Learning
Circadian Rhythm
Response To Radiation
Response To Mechanical Stimulus
Response To Lipopolysaccharide
Response To Cytokine
Cellular Response To Reactive Oxygen Species
Fc-epsilon Receptor Signaling Pathway
Regulation Of Cell Population Proliferation
Response To Drug
Response To Hydrogen Peroxide
Positive Regulation Of Apoptotic Process
Negative Regulation Of DNA Binding
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of GTPase Activity
Negative Regulation By Host Of Viral Transcription
Positive Regulation By Host Of Viral Transcription
Positive Regulation Of Monocyte Differentiation
Positive Regulation Of DNA Replication
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-binding Transcription Factor Activity
Cellular Response To Potassium Ion Starvation
Response To CAMP
Regulation Of Cell Cycle
Membrane Depolarization
SMAD Protein Signal Transduction
Cellular Response To Cadmium Ion
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Positive Regulation Of DNA-templated Transcription, Initiation
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Protein Targeting To Lysosome
Lysosomal Transport
Neuromuscular Junction Development
Negative Regulation Of Sodium Ion Transport
Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Regulation Of Macroautophagy
Protein Ubiquitination
Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neuron Projection Development
Receptor Internalization
Receptor Catabolic Process
Cellular Response To UV
Regulation Of Ion Transmembrane Transport
Regulation Of Membrane Potential
Glucocorticoid Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Development Involved In Symbiotic Interaction
Positive Regulation Of Protein Catabolic Process
Viral Budding
Positive Regulation Of Nucleocytoplasmic Transport
Regulation Of Dendrite Morphogenesis
Regulation Of Synapse Organization
Progesterone Receptor Signaling Pathway
Response To Calcium Ion
Protein K63-linked Ubiquitination
Regulation Of Potassium Ion Transmembrane Transporter Activity
Negative Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways
Pre-NOTCH Transcription and Translation
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
FCERI mediated MAPK activation
Activation of the AP-1 family of transcription factors
Activation of anterior HOX genes in hindbrain development during early embryogenesis
MAPK6/MAPK4 signaling
TP53 Regulates Transcription of DNA Repair Genes
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Estrogen-dependent gene expression
WNT5:FZD7-mediated leishmania damping
ISG15 antiviral mechanism
Downregulation of ERBB4 signaling
Regulation of PTEN localization
Regulation of PTEN stability and activity
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Adapalene
Vinblastine
Pseudoephedrine
Irbesartan
Arsenic trioxide
LGD-1550
Diseases
GWAS
Cognitive performance (
19734545
)
Night sleep phenotypes (
27126917
)
Brain connectivity (
23471985
)
Chronic lymphocytic leukemia (
28165464
24292274
)
Dupuytren's disease (
28886342
)
Hip circumference adjusted for BMI (
28552196
)
Intraocular pressure (
29617998
)
Joint mobility (Beighton score) (
27182965
)
Keloid (
20711176
)
Refractive error (
32231278
)
Stroke (
29531354
)
Interacting Genes
180 interacting genes:
ABL1
AKAP5
APLP2
APP
AR
ARRB1
ATF1
ATF2
ATF3
ATF4
BATF
BATF2
BBS7
BCL3
BCL6
BLM
BRCA1
CASP9
CCND1
CEBPE
CEBPG
CLINT1
COP1
COPS5
CREB3
CREB5
CREBBP
CSNK2A1
DACH1
DDIT3
DDX21
DHX9
DNMT3L
EDF1
EGR1
ELF3
ELOF1
EN1
EP300
EPAS1
ERG
ESR1
ETS1
ETS2
ETV1
ETV4
EWSR1
FBXW7
FOS
FOSB
FOSL1
FOSL2
GATA2
GOPC
GSK3B
GTF2B
GTF2E2
GTF2F1
GTF2F2
HCFC1
HDAC3
HDAC9
HDGF
HHEX
HIF1A
HMGA1
HNRNPM
HOXA9
HOXC8
HSP90AA1
HSPA8
IKBKB
IRAK1
ITCH
ITPK1
JDP2
KLF5
KMT2C
KPNA2
M6PR
MACF1
MAF
MAFB
MAP2K4
MAP2K7
MAPK1
MAPK10
MAPK11
MAPK14
MAPK3
MAPK8
MAPK9
MAPKAPK5
MAPRE3
MBD3
MDM2
MOK
MTA1
MYBBP1A
MYOD1
NACA
NAT14
NCOA1
NCOA2
NCOA3
NCOA6
NCOR2
NEDD4
NELFB
NFE2L1
NFE2L2
NFYA
NR3C1
NR5A1
NRIP1
NTRK3
PACS1
PHOX2A
PIAS1
PIAS2
PIN1
POU1F1
PPARG
PPP3CB
PPP4C
PRKD1
PRKDC
PRRC2A
RB1
RBM39
RELA
RNF187
RPL18A
RPS6KA2
RUNX1
RUNX2
SKI
SMAD2
SMAD3
SMAD4
SMARCD1
SMARCD3
SNAPC5
SNRK
SOX10
SOX8
SP1
SPI1
SPIB
STAT1
STAT3
STAT4
STRN4
SUMO1
SUMO2
SUMO3
SUMO4
TAF1
TAF4
TBP
TCF20
TCF4
TDG
TGIF1
TOP1
TOP2A
TP53
TPM1
TPM2
TRAF2
TRIP4
TSC22D3
TSG101
UBB
UBC
UBE2I
USP6
VAV1
VDR
ZBTB7C
238 interacting genes:
ABCB1
ABL1
ABL2
ADRB2
AKT3
AMOT
AMOTL1
AMPD2
ANKRD13D
ANXA13
AP1G2
ARID1A
ASPSCR1
AURKC
BAIAP2
BMPR1A
BRCA2
CAD
CALCOCO1
CAMK1D
CAMK4
CAMKK2
CASP1
CASP3
CASP6
CASP7
CBLB
CCNH
CDC25C
CDK5
CDK5R1
CLIC2
CLK3
CPSF1
CPSF6
CUEDC1
DAZAP2
DCUN1D1
DDX3X
DDX54
DHX30
DIAPH1
DVL1
DYRK4
EBAG9
EGFR
EPHA5
EPRS1
EPS15
ERBB3
ERBB4
ERMN
ERRFI1
FES
FGF12
FGF21
FGFR1
FGFR2
FKBP3
FLT1
FLT4
FYN
GABARAP
GABARAPL1
GABARAPL2
GBA
GFUS
GRB10
GRIN2A
GRK4
GRK7
H3-3A
HGS
HMCES
HNRNPK
HNRNPL
HNRNPU
HNRNPUL1
IFITM3
IGF1R
IRS1
IRS2
JHY
JUN
KCNAB1
KCNAB2
KCNJ16
KIFC3
LAPTM5
LATS1
LINC01198
LITAF
LUC7L2
MAP1LC3A
MAP1LC3B
MAP1LC3C
MAP3K2
MAP3K3
MAP3K5
MAP4K5
MAPKAPK3
MARK2
MARK4
MLANA
MOB3A
MRPL19
MTMR4
MYCN
MYO15B
N4BP2
N4BP3
NDFIP1
NDFIP2
NFE2
NHP2
NSRP1
NUDT21
NUMB
PARP16
PAX7
PDGFRB
PIP5K1A
PIP5K1C
PKN2
PLK1
PLK2
PMEPA1
POLR1C
POLR2A
POLR2B
POLR2C
POLR2E
POLR2M
POLR3A
PRKG2
PRKX
PRPF8
PRR16
PRRG1
PRRG2
PSMD4
PYM1
RAC1
RAD51AP1
RAF1
RANBP10
RAP2A
RAPGEF2
RAPGEF6
RASGEF1A
RASL11B
RBCK1
RET
RFT1
RNF11
RNF7
RPAP2
RPAP3
RPL18A
RPS3A
RPS6KA3
RPS6KA4
RPS6KB1
RUNX1
RUVBL1
SAAL1
SAMSN1
SAV1
SCAMP3
SCN5A
SCNN1A
SCNN1B
SCNN1G
SEPTIN9
SERTAD1
SFTPC
SGK1
SGK2
SH3KBP1
SHISA6
SHTN1
SIVA1
SLC23A2
SLC6A3
SMAD1
SMAD3
SMAD5
SMARCC1
SMO
SNCA
SP140L
SPANXN3
SPRY2
SRC
SRMS
SRSF7
STK24
STK25
STK26
STK31
STK4
SULF1
SYK
SYT1
TAF1B
TBC1D7
TBK1
TCEANC
TCP11L1
TEAD2
THOC1
THRAP3
TNIK
TOM1
TOM1L2
TP53BP2
TP73
TRIM44
TRIM52
TRPV6
TTYH2
UBAP2L
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2L3
UBE2M
UBOX5
URI1
VDAC2
VDAC3
WBP1
WBP2
WEE1
YES1
YOD1
Entrez ID
3725
4734
HPRD ID
01302
03786
Ensembl ID
ENSG00000177606
ENSG00000069869
Uniprot IDs
P05412
P46934
PDB IDs
1A02
1FOS
1JNM
1JUN
1S9K
1T2K
5FV8
5T01
2KPZ
2KQ0
2M3O
2XBB
2XBF
3B7Y
4BBN
4BE8
4N7F
4N7H
5AHT
5C7J
5C91
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?