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TDG and SIRT6
Data Source:
BioGRID
(two hybrid)
TDG
SIRT6
Description
thymine DNA glycosylase
sirtuin 6
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Plasma Membrane
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Chromosome, Subtelomeric Region
Molecular Function
Magnesium Ion Binding
DNA Binding
Damaged DNA Binding
Double-stranded DNA Binding
Uracil DNA N-glycosylase Activity
Protein Binding
ATP Binding
Transcription Factor Binding
Pyrimidine-specific Mismatch Base Pair DNA N-glycosylase Activity
DNA N-glycosylase Activity
Protein Domain Specific Binding
Mismatched DNA Binding
Sodium Ion Binding
Chloride Ion Binding
SUMO Binding
Protein Homodimerization Activity
Protein Self-association
G/U Mismatch-specific Uracil-DNA Glycosylase Activity
Transcription Corepressor Activity
NAD+ ADP-ribosyltransferase Activity
NAD(P)+-protein-arginine ADP-ribosyltransferase Activity
Histone Deacetylase Activity
Protein Binding
Zinc Ion Binding
NAD-dependent Histone Deacetylase Activity
Deacetylase Activity
NAD-dependent Protein Deacetylase Activity
NAD-dependent Histone Deacetylase Activity (H3-K9 Specific)
NAD+ Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Base-excision Repair
Base-excision Repair, AP Site Formation
Mismatch Repair
Chromatin Organization
Oxidative DNA Demethylation
Regulation Of Gene Expression, Epigenetic
Depyrimidination
Regulation Of Embryonic Development
DNA Demethylation
Regulation Of DNA N-glycosylase Activity
Negative Regulation Of Transcription By RNA Polymerase II
Post-embryonic Cardiac Muscle Cell Growth Involved In Heart Morphogenesis
Protein ADP-ribosylation
Protein Deacetylation
Regulation Of Double-strand Break Repair Via Homologous Recombination
Response To Nutrient Levels
Positive Regulation Of Chromatin Silencing At Telomere
Positive Regulation Of Telomere Maintenance
Histone H3-K9 Modification
Histone H3 Deacetylation
Positive Regulation Of Cold-induced Thermogenesis
Positive Regulation Of Transcription Factor Catabolic Process
Positive Regulation Of Chondrocyte Proliferation
Positive Regulation Of Subtelomeric Heterochromatin Assembly
Positive Regulation Of Blood Vessel Branching
Positive Regulation Of Vascular Endothelial Cell Proliferation
Histone H3-K9 Deacetylation
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Displacement of DNA glycosylase by APEX1
SUMOylation of DNA damage response and repair proteins
TET1,2,3 and TDG demethylate DNA
Pre-NOTCH Transcription and Translation
Processing of DNA double-strand break ends
Drugs
Diseases
GWAS
Glucagon levels in response to oral glucose tolerance test (fasting) (
29093273
)
Metabolite levels (
23823483
)
Interacting Genes
36 interacting genes:
AR
CREBBP
CRK
DDX39B
DNMT3B
DTL
EP300
EPM2A
ESR1
HUS1
IKZF1
JUN
JUNB
MX1
NKX2-1
NR3C1
PCNA
PGR
PML
RAD1
RAD23B
RAD9A
RXRA
SERBP1
SIRT6
SKIL
SMAD4
SNIP1
STAT3
SUMO1
SUMO2
SUMO3
THRA
UBE2I
VDR
XPC
17 interacting genes:
AKT1
CCNDBP1
CDKN1B
CHD3
ELF5
FAF1
HUS1
MUTYH
RAD1
SKP2
STUB1
TDG
TSPYL2
UBE2D1
UBE3A
USP10
VIM
Entrez ID
6996
51548
HPRD ID
03251
12093
Ensembl ID
ENSG00000139372
ENSG00000077463
Uniprot IDs
B4DI29
B4E127
Q13569
B4DDV3
M0QXA0
M0R1N9
Q8N6T7
PDB IDs
1WYW
2D07
2RBA
3UFJ
3UO7
3UOB
4FNC
4JGC
4XEG
4Z3A
4Z47
4Z7B
4Z7Z
5CYS
5FF8
5HF7
5JXY
5T2W
6U15
6U16
6U17
3K35
3PKI
3PKJ
3ZG6
5MF6
5MFP
5MFZ
5MGN
5X16
5Y2F
6HOY
6QCD
6QCE
6QCH
6QCJ
6XUY
6XV1
6XV6
6XVG
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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