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TDG and RAD1
Data Source:
BioGRID
(pull down)
TDG
RAD1
Description
thymine DNA glycosylase
RAD1 checkpoint DNA exonuclease
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Plasma Membrane
Nucleus
Nucleoplasm
Chromosome
Checkpoint Clamp Complex
Intracellular Membrane-bounded Organelle
Molecular Function
Magnesium Ion Binding
DNA Binding
Damaged DNA Binding
Double-stranded DNA Binding
Uracil DNA N-glycosylase Activity
Protein Binding
ATP Binding
Transcription Factor Binding
Pyrimidine-specific Mismatch Base Pair DNA N-glycosylase Activity
DNA N-glycosylase Activity
Protein Domain Specific Binding
Mismatched DNA Binding
Sodium Ion Binding
Chloride Ion Binding
SUMO Binding
Protein Homodimerization Activity
Protein Self-association
G/U Mismatch-specific Uracil-DNA Glycosylase Activity
Damaged DNA Binding
Protein Binding
3'-5' Exonuclease Activity
Exodeoxyribonuclease III Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Base-excision Repair
Base-excision Repair, AP Site Formation
Mismatch Repair
Chromatin Organization
Oxidative DNA Demethylation
Regulation Of Gene Expression, Epigenetic
Depyrimidination
Regulation Of Embryonic Development
DNA Demethylation
Regulation Of DNA N-glycosylase Activity
DNA Damage Checkpoint
DNA Replication
DNA Repair
Cellular Response To DNA Damage Stimulus
Substantia Nigra Development
Meiotic Recombination Checkpoint
Cellular Response To Ionizing Radiation
Nucleic Acid Phosphodiester Bond Hydrolysis
Regulation Of Signal Transduction By P53 Class Mediator
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Displacement of DNA glycosylase by APEX1
SUMOylation of DNA damage response and repair proteins
TET1,2,3 and TDG demethylate DNA
Activation of ATR in response to replication stress
HDR through Single Strand Annealing (SSA)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Drugs
Diseases
GWAS
Glucagon levels in response to oral glucose tolerance test (fasting) (
29093273
)
Metabolite levels (
23823483
)
Daytime sleep phenotypes (
27126917
)
Interacting Genes
36 interacting genes:
AR
CREBBP
CRK
DDX39B
DNMT3B
DTL
EP300
EPM2A
ESR1
HUS1
IKZF1
JUN
JUNB
MX1
NKX2-1
NR3C1
PCNA
PGR
PML
RAD1
RAD23B
RAD9A
RXRA
SERBP1
SIRT6
SKIL
SMAD4
SNIP1
STAT3
SUMO1
SUMO2
SUMO3
THRA
UBE2I
VDR
XPC
24 interacting genes:
COPS5
CSNK2A1
CSNK2A2
DNAJC7
FEN1
HUS1
HUS1B
MAP1LC3B
MSH2
MSH3
MSH6
NEIL1
OGG1
POLB
PRKN
RAD17
RAD9B
RHNO1
RPA1
RPA2
SIRT6
TDG
TOPBP1
WRN
Entrez ID
6996
5810
HPRD ID
03251
04400
Ensembl ID
ENSG00000139372
ENSG00000113456
Uniprot IDs
B4DI29
B4E127
Q13569
A0A024R045
O60671
PDB IDs
1WYW
2D07
2RBA
3UFJ
3UO7
3UOB
4FNC
4JGC
4XEG
4Z3A
4Z47
4Z7B
4Z7Z
5CYS
5FF8
5HF7
5JXY
5T2W
6U15
6U16
6U17
3A1J
3G65
3GGR
6J8Y
Enriched GO Terms of Interacting Partners
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