Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
JUN and MDM2
Data Source:
BioGRID
(pull down)
JUN
MDM2
Description
Jun proto-oncogene, AP-1 transcription factor subunit
MDM2 proto-oncogene
Image
GO Annotations
Cellular Component
Nuclear Chromosome
Chromatin
Euchromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytosol
Plasma Membrane
Transcription Factor AP-1 Complex
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
Nuclear Body
Endocytic Vesicle Membrane
Protein-containing Complex
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Activating Transcription Factor Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
RNA Binding
GTPase Activator Activity
Protein Binding
Transcription Factor Binding
Enzyme Binding
Ubiquitin Protein Ligase Binding
CAMP Response Element Binding
Identical Protein Binding
Ubiquitin-like Protein Ligase Binding
Protein-containing Complex Binding
R-SMAD Binding
HMG Box Domain Binding
Sequence-specific Double-stranded DNA Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
P53 Binding
Ubiquitin-protein Transferase Activity
Protein Binding
5S RRNA Binding
Zinc Ion Binding
Ligase Activity
SUMO Transferase Activity
Enzyme Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Ribonucleoprotein Complex Binding
Ubiquitin Binding
Protein N-terminus Binding
Ubiquitin Protein Ligase Activity
NEDD8 Ligase Activity
Disordered Domain Specific Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Angiogenesis
Release Of Cytochrome C From Mitochondria
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Transforming Growth Factor Beta Receptor Signaling Pathway
Ras Protein Signal Transduction
Aging
Learning
Circadian Rhythm
Response To Radiation
Response To Mechanical Stimulus
Response To Lipopolysaccharide
Response To Cytokine
Cellular Response To Reactive Oxygen Species
Fc-epsilon Receptor Signaling Pathway
Regulation Of Cell Population Proliferation
Response To Drug
Response To Hydrogen Peroxide
Positive Regulation Of Apoptotic Process
Negative Regulation Of DNA Binding
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of GTPase Activity
Negative Regulation By Host Of Viral Transcription
Positive Regulation By Host Of Viral Transcription
Positive Regulation Of Monocyte Differentiation
Positive Regulation Of DNA Replication
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-binding Transcription Factor Activity
Cellular Response To Potassium Ion Starvation
Response To CAMP
Regulation Of Cell Cycle
Membrane Depolarization
SMAD Protein Signal Transduction
Cellular Response To Cadmium Ion
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Positive Regulation Of DNA-templated Transcription, Initiation
Negative Regulation Of Transcription By RNA Polymerase II
Protein Polyubiquitination
Regulation Of Transcription By RNA Polymerase II
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Positive Regulation Of Cell Population Proliferation
Viral Process
Protein Ubiquitination
Protein Deubiquitination
Protein Sumoylation
Protein Phosphopantetheinylation
Protein Destabilization
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Localization To Nucleus
Transcription Factor Catabolic Process
Regulation Of Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Establishment Of Protein Localization
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
Response To Antibiotic
Proteolysis Involved In Cellular Protein Catabolic Process
Protein Autoubiquitination
Protein-containing Complex Assembly
Negative Regulation Of Cell Cycle Arrest
Cellular Response To Hypoxia
Cellular Response To Gamma Radiation
Cellular Response To Actinomycin D
Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Amyloid Fibril Formation
Pathways
Pre-NOTCH Transcription and Translation
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
FCERI mediated MAPK activation
Activation of the AP-1 family of transcription factors
Activation of anterior HOX genes in hindbrain development during early embryogenesis
MAPK6/MAPK4 signaling
TP53 Regulates Transcription of DNA Repair Genes
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Estrogen-dependent gene expression
WNT5:FZD7-mediated leishmania damping
AKT phosphorylates targets in the cytosol
Oxidative Stress Induced Senescence
Oncogene Induced Senescence
SUMOylation of transcription factors
SUMOylation of ubiquitinylation proteins
Trafficking of AMPA receptors
Constitutive Signaling by AKT1 E17K in Cancer
Ub-specific processing proteases
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
Regulation of TP53 Activity through Methylation
Stabilization of p53
Regulation of RUNX3 expression and activity
Drugs
Adapalene
Vinblastine
Pseudoephedrine
Irbesartan
Arsenic trioxide
LGD-1550
Zinc
Cis-[4,5-Bis-(4-Bromophenyl)-2-(2-Ethoxy-4-Methoxyphenyl)-4,5-Dihydroimidazol-1-Yl]-[4-(2-Hydroxyethyl)Piperazin-1-Yl]Methanone
Cis-[4,5-Bis-(4-Chlorophenyl)-2-(2-Isopropoxy-4-Methoxyphenyl)-4,5-Dihyd Roimidazol-1-Yl]-Piperazin-1-Yl-Methanone
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
Choriocarcinoma
Osteosarcoma
Glioma
Penile cancer
Alveolar rhabdomyosarcoma
GWAS
Cognitive performance (
19734545
)
Night sleep phenotypes (
27126917
)
Pneumoconiosis in silica exposure (
24986923
)
Red blood cell count (
32888494
)
Interacting Genes
180 interacting genes:
ABL1
AKAP5
APLP2
APP
AR
ARRB1
ATF1
ATF2
ATF3
ATF4
BATF
BATF2
BBS7
BCL3
BCL6
BLM
BRCA1
CASP9
CCND1
CEBPE
CEBPG
CLINT1
COP1
COPS5
CREB3
CREB5
CREBBP
CSNK2A1
DACH1
DDIT3
DDX21
DHX9
DNMT3L
EDF1
EGR1
ELF3
ELOF1
EN1
EP300
EPAS1
ERG
ESR1
ETS1
ETS2
ETV1
ETV4
EWSR1
FBXW7
FOS
FOSB
FOSL1
FOSL2
GATA2
GOPC
GSK3B
GTF2B
GTF2E2
GTF2F1
GTF2F2
HCFC1
HDAC3
HDAC9
HDGF
HHEX
HIF1A
HMGA1
HNRNPM
HOXA9
HOXC8
HSP90AA1
HSPA8
IKBKB
IRAK1
ITCH
ITPK1
JDP2
KLF5
KMT2C
KPNA2
M6PR
MACF1
MAF
MAFB
MAP2K4
MAP2K7
MAPK1
MAPK10
MAPK11
MAPK14
MAPK3
MAPK8
MAPK9
MAPKAPK5
MAPRE3
MBD3
MDM2
MOK
MTA1
MYBBP1A
MYOD1
NACA
NAT14
NCOA1
NCOA2
NCOA3
NCOA6
NCOR2
NEDD4
NELFB
NFE2L1
NFE2L2
NFYA
NR3C1
NR5A1
NRIP1
NTRK3
PACS1
PHOX2A
PIAS1
PIAS2
PIN1
POU1F1
PPARG
PPP3CB
PPP4C
PRKD1
PRKDC
PRRC2A
RB1
RBM39
RELA
RNF187
RPL18A
RPS6KA2
RUNX1
RUNX2
SKI
SMAD2
SMAD3
SMAD4
SMARCD1
SMARCD3
SNAPC5
SNRK
SOX10
SOX8
SP1
SPI1
SPIB
STAT1
STAT3
STAT4
STRN4
SUMO1
SUMO2
SUMO3
SUMO4
TAF1
TAF4
TBP
TCF20
TCF4
TDG
TGIF1
TOP1
TOP2A
TP53
TPM1
TPM2
TRAF2
TRIP4
TSC22D3
TSG101
UBB
UBC
UBE2I
USP6
VAV1
VDR
ZBTB7C
261 interacting genes:
ABL1
ABL2
ADRB2
AKAP5
AKT1
ANKRD17
APEX1
APP
AR
ARRB1
ARRB2
ATF4
ATM
ATP2A2
ATRX
AURKA
BAIAP2L1
BRINP1
BTK
BTRC
CANX
CASP2
CASP3
CCAR1
CCNG1
CDC34
CDH1
CDKN2A
CHEK2
CLSTN1
CLU
COPS5
CREBBP
CSNK2A1
CSNK2A2
CSNK2B
CTBP2
CWC25
DAPK1
DAPK3
DAXX
DDX24
DDX42
DHFR
DLG4
DNAJB4
DYRK2
E2F1
EGLN3
EID1
EP300
ESR1
EZR
F3
FBXO31
FHL2
FKBP1A
FOS
FOXO1
FOXO3
G3BP2
GADD45A
GCAT
GLIS2
GNL3
GORAB
GRK2
GSK3B
GTF2E2
GYS2
H2BC21
H3-4
HCK
HDAC1
HEY1
HIF1A
HIPK2
HLA-DMB
HMGA2
HMGN1
HNRNPK
HSP90B1
IER3
IGF1R
IRF1
IRF2
JMY
JUN
JUND
KAT2B
KAT5
KPNA1
LMO7
MAGEA2
MAP1LC3A
MAP2
MAPKAPK2
MDM4
MED1
MKRN3
MS4A1
MTBP
MYC
MYD88
MYDGF
NACA
NAT10
NCL
NDUFS1
NGFR
NOLC1
NOP53
NOTCH1
NPIPB3
NPM1
NR3C1
NUCKS1
NUMB
PAK6
PBX1
PBXIP1
PDE4D
PDIA3
PDLIM7
PDS5A
PER2
PGAM2
PHF7
PHLDB3
PIAS1
PJA1
PKM
PLK1
PML
POLE
POT1
PPIB
PPM1D
PPP1R10
PRDM2
PRKN
PSMA3
PSMC5
PSMD10
PSMD4
PSME3
PTK2
RAB8A
RAD23A
RANBP1
RANBP2
RARA
RASSF1
RB1
RBBP6
RBM10
RBM38
RCHY1
RESF1
RIDA
RLIM
RNF10
RNF126
RNF8
RPL11
RPL22
RPL26
RPL36A
RPL4
RPL5
RPS23
RPS27A
RPS3
RPS5
RRM2B
RRP1
RSL1D1
RUVBL2
RYBP
RYR2
S100A1
S100A2
S100A4
S100A6
S100B
SDHC
SENP3
SESN2
SET
SETD7
SETDB1
SHPK
SIRT2
SIRT3
SMARCA2
SMARCA4
SMARCE1
SMG7
SORBS2
SRC
SREK1
SRSF11
STK11
SUMO1
TAF1
TBP
TCAP
TERT
TFIP11
TOP1
TP53
TP53I3
TP53RK
TP73
TPR
TPT1
TRAF5
TRIM13
TRIM23
TRIM27
TRIM4
TRIM9
TSG101
UBB
UBC
UBE2A
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2G2
UBE2I
UBE2J2
UBE2K
UBE2L3
UBE2N
UBE2O
UBE2Q1
UBE2Q2
UBE2R2
UBE2S
UBE2U
UBE2Z
UBE3A
UBQLN4
UBTF
USP15
USP2
USP7
VEGFA
WRN
WT1
XBP1
XIAP
XPC
YY1AP1
ZNF133
ZNF420
Entrez ID
3725
4193
HPRD ID
01302
01272
Ensembl ID
ENSG00000177606
ENSG00000135679
Uniprot IDs
P05412
A0A0A8KB75
A7UKX7
A7UKX8
A7UKX9
G3XA89
Q00987
Q96DS0
PDB IDs
1A02
1FOS
1JNM
1JUN
1S9K
1T2K
5FV8
5T01
1RV1
1T4E
1T4F
1YCR
1Z1M
2AXI
2C6A
2C6B
2F1Y
2FOP
2GV2
2HDP
2LZG
2M86
2MPS
2RUH
2VJE
2VJF
3EQS
3G03
3IUX
3IWY
3JZK
3JZR
3JZS
3LBK
3LBL
3LNJ
3LNZ
3MQS
3TJ2
3TPX
3TU1
3V3B
3VBG
3VZV
3W69
4DIJ
4ERE
4ERF
4HBM
4HFZ
4HG7
4JV7
4JV9
4JVE
4JVR
4JWR
4MDN
4MDQ
4OAS
4OBA
4OCC
4ODE
4ODF
4OGN
4OGT
4OGV
4OQ3
4QO4
4QOC
4UD7
4UE1
4UMN
4WT2
4XXB
4ZFI
4ZGK
4ZYC
4ZYF
4ZYI
5AFG
5C5A
5HMH
5HMI
5HMK
5J7F
5J7G
5LAV
5LAW
5LAY
5LAZ
5LN2
5MNJ
5OAI
5OC8
5SWK
5TRF
5UMM
5VK0
5WTS
5XXK
5Z02
5ZXF
6AAW
6GGN
6H22
6HFA
6I29
6I3S
6IM9
6KZU
6Q96
6Q9H
6Q9L
6Q9O
6SQO
6T2D
6T2E
6T2F
6Y4Q
7AD0
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?