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TDG
Description
thymine DNA glycosylase
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Plasma Membrane
Molecular Function
Magnesium Ion Binding
DNA Binding
Damaged DNA Binding
Double-stranded DNA Binding
Uracil DNA N-glycosylase Activity
Protein Binding
ATP Binding
Transcription Factor Binding
Pyrimidine-specific Mismatch Base Pair DNA N-glycosylase Activity
DNA N-glycosylase Activity
Protein Domain Specific Binding
Mismatched DNA Binding
Sodium Ion Binding
Chloride Ion Binding
SUMO Binding
Protein Homodimerization Activity
Protein Self-association
G/U Mismatch-specific Uracil-DNA Glycosylase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Base-excision Repair
Base-excision Repair, AP Site Formation
Mismatch Repair
Chromatin Organization
Oxidative DNA Demethylation
Regulation Of Gene Expression, Epigenetic
Depyrimidination
Regulation Of Embryonic Development
DNA Demethylation
Regulation Of DNA N-glycosylase Activity
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Displacement of DNA glycosylase by APEX1
SUMOylation of DNA damage response and repair proteins
TET1,2,3 and TDG demethylate DNA
Drugs
Diseases
GWAS
Glucagon levels in response to oral glucose tolerance test (fasting) (
29093273
)
Metabolite levels (
23823483
)
Interacting Genes
36 interacting genes:
AR
CREBBP
CRK
DDX39B
DNMT3B
DTL
EP300
EPM2A
ESR1
HUS1
IKZF1
JUN
JUNB
MX1
NKX2-1
NR3C1
PCNA
PGR
PML
RAD1
RAD23B
RAD9A
RXRA
SERBP1
SIRT6
SKIL
SMAD4
SNIP1
STAT3
SUMO1
SUMO2
SUMO3
THRA
UBE2I
VDR
XPC
Entrez ID
6996
HPRD ID
03251
Ensembl ID
ENSG00000139372
Uniprot IDs
B4DI29
B4E127
Q13569
PDB IDs
1WYW
2D07
2RBA
3UFJ
3UO7
3UOB
4FNC
4JGC
4XEG
4Z3A
4Z47
4Z7B
4Z7Z
5CYS
5FF8
5HF7
5JXY
5T2W
6U15
6U16
6U17
Enriched GO Terms of Interacting Partners
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