HTR6 and ATXN10

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		HTR6	ATXN10
Description		5-hydroxytryptamine receptor 6	ataxin 10
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cilium Dendrite Synapse	Extracellular Space Cytoplasm Cytosol Plasma Membrane Membrane Dendrite Neuronal Cell Body Perinuclear Region Of Cytoplasm
	Molecular Function	Histamine Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity	Protein Binding Enzyme Binding Identical Protein Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Chemical Synaptic Transmission Cerebral Cortex Cell Migration Positive Regulation Of TOR Signaling G Protein-coupled Serotonin Receptor Signaling Pathway	Nervous System Development Neuron Projection Development Cilium Assembly
Pathways		Serotonin receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs		Ziprasidone Amitriptyline Olanzapine Clozapine Loxapine Imipramine Chlorpromazine Haloperidol Amoxapine Paroxetine Cyclobenzaprine Ergoloid mesylate Doxepin Quetiapine Aripiprazole Chlorprothixene Dimethyltryptamine Lysergic acid diethylamide Iloperidone SGS518 PRX-07034 SUVN-502 Sertindole Mianserin Asenapine Zotepine Setiptiline Dihydroergocornine Gilteritinib Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Chronotype ( 26955885 27494321) Morning person ( 30696823) Morning vs. evening chronotype ( 26955885 27494321)	Blond vs. brown/black hair color ( 30531825) Heel bone mineral density ( 30598549) Hematocrit ( 29403010) Hemoglobin ( 29403010) Hip circumference ( 28552196) Waist circumference ( 28552196)
Interacting Genes		31 interacting genes: ABCA2 ACTB AIP AKR1A1 AP2M1 AP4S1 ATXN10 CHN1 CMSS1 COPS5 DDRGK1 DHRS1 EIF4A3 FYN GNAQ GNAS HDGFL2 IDS MAP1B NF1 NRXN3 PARP8 RUNDC3A SCHIP1 SLC6A1 SRRT SYT5 THY1 TMEM98 TTYH1 UQCRFS1	12 interacting genes: ABCA1 FN1 GLS GNB1 GNB2 GOLGA1 HSPB1 HTR6 LIMS1 MRPS16 PPP1R12A PTGER4
Entrez ID		3362	25814
HPRD ID		03066	04624
Ensembl ID		ENSG00000158748	ENSG00000130638
Uniprot IDs		P50406	Q9UBB4
PDB IDs
Enriched GO Terms of Interacting Partners?
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